Cytomegalovirus infection in non-immunosuppressed critically ill patients
Cytomegalovirus (CMV) is an important and common cause of mortality and morbidity in immunocompromised patients such as those with HIV/AIDS, transplant recipients on immunosuppressive therapy, and malignant hematological disease. After primary infection with CMV the virus becomes latent in multiple...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2011-03-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/1487 |
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| author | Manisha Jain Shalini Duggal Tulsi Das Chugh |
| author_facet | Manisha Jain Shalini Duggal Tulsi Das Chugh |
| author_sort | Manisha Jain |
| collection | DOAJ |
| description |
Cytomegalovirus (CMV) is an important and common cause of mortality and morbidity in immunocompromised patients such as those with HIV/AIDS, transplant recipients on immunosuppressive therapy, and malignant hematological disease. After primary infection with CMV the virus becomes latent in multiple organs and can later be reactivated during severe dysregulation of the immune system. A large population carry dormant virus and are thus at risk for reactivation.
However, reactivation of CMV has been reported in "non-immunosuppressed patients" such as severe trauma, sepsis, shock, burns, cirrhosis and other critically ill patients lying in the intensive care units. Therefore, the intensivists are increasingly facing a dilemma of identifying such patients to treat and there is a debate if there is a scientific justification for prophylaxis in such immunocompetent patients.
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| format | Article |
| id | doaj-art-33a18ac5721a49acbfb1a7888932f8f5 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2011-03-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-33a18ac5721a49acbfb1a7888932f8f52025-08-20T02:57:18ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802011-03-0150810.3855/jidc.1487Cytomegalovirus infection in non-immunosuppressed critically ill patientsManisha Jain0Shalini Duggal1Tulsi Das Chugh2Department of Microbiology, G. B. Pant Hospital, Delhi, IndiaDepartment of Microbiology, B. L. Kapur Memorial Hospital, Delhi, IndiaDepartment of Microbiology, B. L. Kapur Memorial Hospital, Delhi, India Cytomegalovirus (CMV) is an important and common cause of mortality and morbidity in immunocompromised patients such as those with HIV/AIDS, transplant recipients on immunosuppressive therapy, and malignant hematological disease. After primary infection with CMV the virus becomes latent in multiple organs and can later be reactivated during severe dysregulation of the immune system. A large population carry dormant virus and are thus at risk for reactivation. However, reactivation of CMV has been reported in "non-immunosuppressed patients" such as severe trauma, sepsis, shock, burns, cirrhosis and other critically ill patients lying in the intensive care units. Therefore, the intensivists are increasingly facing a dilemma of identifying such patients to treat and there is a debate if there is a scientific justification for prophylaxis in such immunocompetent patients. https://jidc.org/index.php/journal/article/view/1487CMVreactivationcritically illICU patients |
| spellingShingle | Manisha Jain Shalini Duggal Tulsi Das Chugh Cytomegalovirus infection in non-immunosuppressed critically ill patients Journal of Infection in Developing Countries CMV reactivation critically ill ICU patients |
| title | Cytomegalovirus infection in non-immunosuppressed critically ill patients |
| title_full | Cytomegalovirus infection in non-immunosuppressed critically ill patients |
| title_fullStr | Cytomegalovirus infection in non-immunosuppressed critically ill patients |
| title_full_unstemmed | Cytomegalovirus infection in non-immunosuppressed critically ill patients |
| title_short | Cytomegalovirus infection in non-immunosuppressed critically ill patients |
| title_sort | cytomegalovirus infection in non immunosuppressed critically ill patients |
| topic | CMV reactivation critically ill ICU patients |
| url | https://jidc.org/index.php/journal/article/view/1487 |
| work_keys_str_mv | AT manishajain cytomegalovirusinfectioninnonimmunosuppressedcriticallyillpatients AT shaliniduggal cytomegalovirusinfectioninnonimmunosuppressedcriticallyillpatients AT tulsidaschugh cytomegalovirusinfectioninnonimmunosuppressedcriticallyillpatients |