Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside Roadmap
In recent years, the incredible boost in stem cell research has kindled the expectations of both patients and physicians. Mesenchymal progenitors, owing to their availability, ease of manipulation, and therapeutic potential, have become one of the most attractive options for the treatment of a wide...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/175979 |
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| _version_ | 1832551101118808064 |
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| author | Manuel Mazo Miriam Araña Beatriz Pelacho Felipe Prosper |
| author_facet | Manuel Mazo Miriam Araña Beatriz Pelacho Felipe Prosper |
| author_sort | Manuel Mazo |
| collection | DOAJ |
| description | In recent years, the incredible boost in stem cell research has kindled the expectations of both patients and physicians. Mesenchymal progenitors, owing to their availability, ease of manipulation, and therapeutic potential, have become one of the most attractive options for the treatment of a wide range of diseases, from cartilage defects to cardiac disorders. Moreover, their immunomodulatory capacity has opened up their allogenic use, consequently broadening the possibilities for their application. In this review, we will focus on their use in the therapy of myocardial infarction, looking at their characteristics, in vitro and in vivo mechanisms of action, as well as clinical trials. |
| format | Article |
| id | doaj-art-337675636d4746e79163abd4c65ee8f1 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-337675636d4746e79163abd4c65ee8f12025-02-03T06:04:59ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/175979175979Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside RoadmapManuel Mazo0Miriam Araña1Beatriz Pelacho2Felipe Prosper3Department of Hematology and Cell Therapy, Clínica Universidad de Navarra, Foundation for Applied Medical Research, University of Navarra, Avenida Pío XII 36, Pamplona, 31008 Navarra, SpainDepartment of Hematology and Cell Therapy, Clínica Universidad de Navarra, Foundation for Applied Medical Research, University of Navarra, Avenida Pío XII 36, Pamplona, 31008 Navarra, SpainDepartment of Hematology and Cell Therapy, Clínica Universidad de Navarra, Foundation for Applied Medical Research, University of Navarra, Avenida Pío XII 36, Pamplona, 31008 Navarra, SpainDepartment of Hematology and Cell Therapy, Clínica Universidad de Navarra, Foundation for Applied Medical Research, University of Navarra, Avenida Pío XII 36, Pamplona, 31008 Navarra, SpainIn recent years, the incredible boost in stem cell research has kindled the expectations of both patients and physicians. Mesenchymal progenitors, owing to their availability, ease of manipulation, and therapeutic potential, have become one of the most attractive options for the treatment of a wide range of diseases, from cartilage defects to cardiac disorders. Moreover, their immunomodulatory capacity has opened up their allogenic use, consequently broadening the possibilities for their application. In this review, we will focus on their use in the therapy of myocardial infarction, looking at their characteristics, in vitro and in vivo mechanisms of action, as well as clinical trials.http://dx.doi.org/10.1155/2012/175979 |
| spellingShingle | Manuel Mazo Miriam Araña Beatriz Pelacho Felipe Prosper Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside Roadmap Stem Cells International |
| title | Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside Roadmap |
| title_full | Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside Roadmap |
| title_fullStr | Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside Roadmap |
| title_full_unstemmed | Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside Roadmap |
| title_short | Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside Roadmap |
| title_sort | mesenchymal stem cells and cardiovascular disease a bench to bedside roadmap |
| url | http://dx.doi.org/10.1155/2012/175979 |
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