Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil
Summary: Background: Mixed-oil lipid emulsion with plant-based 18-carbon n-3 fatty acids (Vegaven) elicits superior liver protection in total parenteral nutrition (TPN) compared with soybean oil-based or fish oil-based lipid emulsions. Objective: However, it is not known whether Vegaven is also sup...
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| Language: | English |
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Elsevier
2025-04-01
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| Series: | Clinical Nutrition Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268525000099 |
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| author | Eliana Lucchinetti Phing-How Lou Alessandro Quaranta Craig E. Wheelock Akash Chakravarty Martin Hersberger Stefanie D. Krämer Michael Zaugg |
| author_facet | Eliana Lucchinetti Phing-How Lou Alessandro Quaranta Craig E. Wheelock Akash Chakravarty Martin Hersberger Stefanie D. Krämer Michael Zaugg |
| author_sort | Eliana Lucchinetti |
| collection | DOAJ |
| description | Summary: Background: Mixed-oil lipid emulsion with plant-based 18-carbon n-3 fatty acids (Vegaven) elicits superior liver protection in total parenteral nutrition (TPN) compared with soybean oil-based or fish oil-based lipid emulsions. Objective: However, it is not known whether Vegaven is also superior to mixed-oil lipid emulsions containing longer-chain 20/22-carbon n-3 fatty acids derived from fish oil (SMOFlipid). Methods: Instrumented male C57BL/6NCrl mice (N=5) were subjected to a 7-day TPN with Vegaven (VEGA) or SMOFlipid (SMOF). Mice infused with 0.9% saline and free access to water and rodent diet served as controls. Tissue concentration of cytokines, indices of whole-body and hepatic glucose metabolism, markers of liver injury, and hepatic lipid mediators were measured. Results: Whole-body insulin resistance as measured by HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) values was lower in VEGA compared with SMOF and accompanied by higher glucagon and lower insulin plasma levels. The abundances of hepatic insulin receptor (IR), insulin receptor substrate 2 (IRS2) as well as the tyrosine phosphorylated IRS2 were higher in VEGA when compared with SMOF, fostering higher hepatic glycogen content. Tumor necrosis factor alpha and interleukin-6 (IL6) tissue concentrations were increased in livers of mice in the SMOF group and interleukin-6 (IL6) to interleukin-10 (IL10) ratios were lower in livers and epididymal white adipose tissue of mice in the VEGA group. Direct bilirubin plasma levels were elevated in SMOF, while ALT plasma levels were similar in all groups. Profiling of hepatic lipid mediators revealed the presence of α-linolenic acid-derived hydroxy-octadecatrienoic acid species exclusively in VEGA. Conclusions: TPN with Vegaven provides superior liver protection and whole-body blood glucose control than TPN with mixed-oil lipid emulsion containing fish oil in mice. |
| format | Article |
| id | doaj-art-33759a390376416aa2caf216156e3657 |
| institution | Kabale University |
| issn | 2667-2685 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj-art-33759a390376416aa2caf216156e36572025-02-06T05:13:01ZengElsevierClinical Nutrition Open Science2667-26852025-04-01602237Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oilEliana Lucchinetti0Phing-How Lou1Alessandro Quaranta2Craig E. Wheelock3Akash Chakravarty4Martin Hersberger5Stefanie D. Krämer6Michael Zaugg7Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, CanadaDepartment of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Canada; Department of Pharmacology, University of Alberta, Edmonton, CanadaInstitute of Environmental Medicine, Unit of Integrative Metabolomics, Karolinska Institute and Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, SwedenInstitute of Environmental Medicine, Unit of Integrative Metabolomics, Karolinska Institute and Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, SwedenDivision of Clinical Chemistry and Biochemistry, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, SwitzerlandDivision of Clinical Chemistry and Biochemistry, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, SwitzerlandInstitute of Pharmaceutical Sciences, ETH Zurich, Zurich, SwitzerlandDepartment of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Canada; Department of Pharmacology, University of Alberta, Edmonton, Canada; Corresponding author. Department of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Alberta CSB Room 2-150Y, Edmonton, AB, T6G 2G3, CanadaSummary: Background: Mixed-oil lipid emulsion with plant-based 18-carbon n-3 fatty acids (Vegaven) elicits superior liver protection in total parenteral nutrition (TPN) compared with soybean oil-based or fish oil-based lipid emulsions. Objective: However, it is not known whether Vegaven is also superior to mixed-oil lipid emulsions containing longer-chain 20/22-carbon n-3 fatty acids derived from fish oil (SMOFlipid). Methods: Instrumented male C57BL/6NCrl mice (N=5) were subjected to a 7-day TPN with Vegaven (VEGA) or SMOFlipid (SMOF). Mice infused with 0.9% saline and free access to water and rodent diet served as controls. Tissue concentration of cytokines, indices of whole-body and hepatic glucose metabolism, markers of liver injury, and hepatic lipid mediators were measured. Results: Whole-body insulin resistance as measured by HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) values was lower in VEGA compared with SMOF and accompanied by higher glucagon and lower insulin plasma levels. The abundances of hepatic insulin receptor (IR), insulin receptor substrate 2 (IRS2) as well as the tyrosine phosphorylated IRS2 were higher in VEGA when compared with SMOF, fostering higher hepatic glycogen content. Tumor necrosis factor alpha and interleukin-6 (IL6) tissue concentrations were increased in livers of mice in the SMOF group and interleukin-6 (IL6) to interleukin-10 (IL10) ratios were lower in livers and epididymal white adipose tissue of mice in the VEGA group. Direct bilirubin plasma levels were elevated in SMOF, while ALT plasma levels were similar in all groups. Profiling of hepatic lipid mediators revealed the presence of α-linolenic acid-derived hydroxy-octadecatrienoic acid species exclusively in VEGA. Conclusions: TPN with Vegaven provides superior liver protection and whole-body blood glucose control than TPN with mixed-oil lipid emulsion containing fish oil in mice.http://www.sciencedirect.com/science/article/pii/S2667268525000099Total parenteral nutritionLiver protectionInterleukin-10Insulin18-Carbon n-3 fatty acidsα-linolenic acid |
| spellingShingle | Eliana Lucchinetti Phing-How Lou Alessandro Quaranta Craig E. Wheelock Akash Chakravarty Martin Hersberger Stefanie D. Krämer Michael Zaugg Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil Clinical Nutrition Open Science Total parenteral nutrition Liver protection Interleukin-10 Insulin 18-Carbon n-3 fatty acids α-linolenic acid |
| title | Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil |
| title_full | Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil |
| title_fullStr | Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil |
| title_full_unstemmed | Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil |
| title_short | Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil |
| title_sort | superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion vegaven as compared to a mixed oil lipid emulsion containing fish oil |
| topic | Total parenteral nutrition Liver protection Interleukin-10 Insulin 18-Carbon n-3 fatty acids α-linolenic acid |
| url | http://www.sciencedirect.com/science/article/pii/S2667268525000099 |
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