Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus
Background. In systemic lupus erythematosus (SLE), atherosclerosis is attributed to traditional and lupus related risk factors, including metabolic syndrome (MetS), obesity, and inflammation. Objective. To evaluate the association between obesity, measures of body fat content, serum tumor necrosis...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/162047 |
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| author | Nailú Angélica Sinicato Mariana Postal Fernando Augusto Peres Karina de Oliveira Peliçari Roberto Marini Allan de Oliveira dos Santos Celso Dario Ramos Simone Appenzeller |
| author_facet | Nailú Angélica Sinicato Mariana Postal Fernando Augusto Peres Karina de Oliveira Peliçari Roberto Marini Allan de Oliveira dos Santos Celso Dario Ramos Simone Appenzeller |
| author_sort | Nailú Angélica Sinicato |
| collection | DOAJ |
| description | Background. In systemic lupus erythematosus (SLE), atherosclerosis is attributed to traditional and lupus related risk factors, including metabolic syndrome (MetS), obesity, and inflammation. Objective. To evaluate the association between obesity, measures of body fat content, serum tumor necrosis factor alpha (TNF-α), and interleukin (IL)-6 and -10 levels in childhood-onset SLE (cSLE). Methods. We screened consecutive cSLE patients followed up in the Pediatric Rheumatology Outpatient Clinic of the State University of Campinas. cSLE patients were assessed for disease and damage. Obesity was definite as body mass index (BMI) ≥30 kg/m2. Serum TNF-α, IL-6, and IL-10 levels were measured by ELISA. Dual-energy X-ray absorptiometry was used to determine total fat mass, lean mass, and percent of body fat. Results. We included 52 cSLE patients and 52 controls. cSLE patients had higher serum TNF-α (P=0.004), IL-6 (P=0.002), and IL-10 (P<0.001) levels compared to controls. We observed higher serum TNF-α (P=0.036) levels in cSLE patients with obesity. An association between serum TNF-α levels and body fat percent (P=0.046) and total fat mass on trunk region (P=0.035) was observed. Conclusion. Serum TNF-α levels were associated with obesity and body fat content in cSLE. Our finding suggests that obesity may contribute to the increase of serum TNF-α levels in cSLE. |
| format | Article |
| id | doaj-art-33556d57373241a58fd1de27198a9faf |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-33556d57373241a58fd1de27198a9faf2025-02-03T07:26:12ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/162047162047Obesity and Cytokines in Childhood-Onset Systemic Lupus ErythematosusNailú Angélica Sinicato0Mariana Postal1Fernando Augusto Peres2Karina de Oliveira Peliçari3Roberto Marini4Allan de Oliveira dos Santos5Celso Dario Ramos6Simone Appenzeller7Faculty of Medical Science, State University of Campinas, Cidade Universitaria, 13083-970 Campinas, SP, BrazilRheumatology Unit, Department of Medicine, Faculty of Medical Science, State University of Campinas, Cidade Universitária, 13083-970 Campinas, SP, BrazilRheumatology Unit, Department of Medicine, Faculty of Medical Science, State University of Campinas, Cidade Universitária, 13083-970 Campinas, SP, BrazilRheumatology Unit, Department of Medicine, Faculty of Medical Science, State University of Campinas, Cidade Universitária, 13083-970 Campinas, SP, BrazilDepartment of Pediatrics, Faculty of Medical Science, State University of Campinas, Cidade Universitária, 13083-970 Campinas, SP, BrazilDepartment of Radiology, Nuclear Medicine Division, State University of Campinas, Cidade Universitaria, 13083-970 Campinas, SP, BrazilDepartment of Radiology, Nuclear Medicine Division, State University of Campinas, Cidade Universitaria, 13083-970 Campinas, SP, BrazilFaculty of Medical Science, State University of Campinas, Cidade Universitaria, 13083-970 Campinas, SP, BrazilBackground. In systemic lupus erythematosus (SLE), atherosclerosis is attributed to traditional and lupus related risk factors, including metabolic syndrome (MetS), obesity, and inflammation. Objective. To evaluate the association between obesity, measures of body fat content, serum tumor necrosis factor alpha (TNF-α), and interleukin (IL)-6 and -10 levels in childhood-onset SLE (cSLE). Methods. We screened consecutive cSLE patients followed up in the Pediatric Rheumatology Outpatient Clinic of the State University of Campinas. cSLE patients were assessed for disease and damage. Obesity was definite as body mass index (BMI) ≥30 kg/m2. Serum TNF-α, IL-6, and IL-10 levels were measured by ELISA. Dual-energy X-ray absorptiometry was used to determine total fat mass, lean mass, and percent of body fat. Results. We included 52 cSLE patients and 52 controls. cSLE patients had higher serum TNF-α (P=0.004), IL-6 (P=0.002), and IL-10 (P<0.001) levels compared to controls. We observed higher serum TNF-α (P=0.036) levels in cSLE patients with obesity. An association between serum TNF-α levels and body fat percent (P=0.046) and total fat mass on trunk region (P=0.035) was observed. Conclusion. Serum TNF-α levels were associated with obesity and body fat content in cSLE. Our finding suggests that obesity may contribute to the increase of serum TNF-α levels in cSLE.http://dx.doi.org/10.1155/2014/162047 |
| spellingShingle | Nailú Angélica Sinicato Mariana Postal Fernando Augusto Peres Karina de Oliveira Peliçari Roberto Marini Allan de Oliveira dos Santos Celso Dario Ramos Simone Appenzeller Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus Journal of Immunology Research |
| title | Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus |
| title_full | Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus |
| title_fullStr | Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus |
| title_full_unstemmed | Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus |
| title_short | Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus |
| title_sort | obesity and cytokines in childhood onset systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2014/162047 |
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