An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established m...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/2480375 |
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| author | Alexander J. Hron Atsushi Asakura |
| author_facet | Alexander J. Hron Atsushi Asakura |
| author_sort | Alexander J. Hron |
| collection | DOAJ |
| description | Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined. |
| format | Article |
| id | doaj-art-3353a9f4a428421cb65d73fcc01cd283 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-3353a9f4a428421cb65d73fcc01cd2832025-02-03T05:58:36ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/24803752480375An Examination of the Role of Transcriptional and Posttranscriptional Regulation in RhabdomyosarcomaAlexander J. Hron0Atsushi Asakura1Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USAStem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USARhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined.http://dx.doi.org/10.1155/2017/2480375 |
| spellingShingle | Alexander J. Hron Atsushi Asakura An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma Stem Cells International |
| title | An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma |
| title_full | An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma |
| title_fullStr | An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma |
| title_full_unstemmed | An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma |
| title_short | An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma |
| title_sort | examination of the role of transcriptional and posttranscriptional regulation in rhabdomyosarcoma |
| url | http://dx.doi.org/10.1155/2017/2480375 |
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