Atherosclerosis in Juvenile Idiopathic Arthritis
Atherosclerosis is a chronic inflammatory disease of the arteries. Clinical consequences of the atherosclerotic process occur in the adult population, however atherosclerotic process begins in childhood. The classic risk factors for atherosclerosis include obesity, dyslipidaemia, age, gender or fami...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/714732 |
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| author | Ewa Jednacz Lidia Rutkowska-Sak |
| author_facet | Ewa Jednacz Lidia Rutkowska-Sak |
| author_sort | Ewa Jednacz |
| collection | DOAJ |
| description | Atherosclerosis is a chronic inflammatory disease of the arteries. Clinical consequences of the atherosclerotic process occur in the adult population, however atherosclerotic process begins in childhood. The classic risk factors for atherosclerosis include obesity, dyslipidaemia, age, gender or family history. In recent years, attention has been drawn to the similarity between atherosclerotic inflammatory processes and inflammatory changes in the course of systemic connective tissue disease, in particular systemic lupus etythematosus (SLE) or rheumatoid arthritis (RA). There is also observed the similarity of the pathogenetic background of development of atherosclerosis and juvenile idiopathic arthritis (JIA). Elevated levels of pro-inflammatory cytokines are observed in the course of juvenile idiopathic arthritis. Also homocysteine concentrations, which may play a significant role in the development of atherosclerotic lesions, are observed higher in patients with JIA. Some studies revealed higher carotid intima-media thickness (IMT) index values in children with JIA. In view of the fact that atherosclerotic process begins as early as in childhood, the introduction of appropriate preventive measures in children is a matter of utmost importance. |
| format | Article |
| id | doaj-art-3348776f75834205bf8172f25d15ad65 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3348776f75834205bf8172f25d15ad652025-02-03T01:23:55ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/714732714732Atherosclerosis in Juvenile Idiopathic ArthritisEwa Jednacz0Lidia Rutkowska-Sak1Paediatric Clinic of Rheumatology, Institute of Rheumatology, Spartańska 1, 02-637 Warsaw, PolandPaediatric Clinic of Rheumatology, Institute of Rheumatology, Spartańska 1, 02-637 Warsaw, PolandAtherosclerosis is a chronic inflammatory disease of the arteries. Clinical consequences of the atherosclerotic process occur in the adult population, however atherosclerotic process begins in childhood. The classic risk factors for atherosclerosis include obesity, dyslipidaemia, age, gender or family history. In recent years, attention has been drawn to the similarity between atherosclerotic inflammatory processes and inflammatory changes in the course of systemic connective tissue disease, in particular systemic lupus etythematosus (SLE) or rheumatoid arthritis (RA). There is also observed the similarity of the pathogenetic background of development of atherosclerosis and juvenile idiopathic arthritis (JIA). Elevated levels of pro-inflammatory cytokines are observed in the course of juvenile idiopathic arthritis. Also homocysteine concentrations, which may play a significant role in the development of atherosclerotic lesions, are observed higher in patients with JIA. Some studies revealed higher carotid intima-media thickness (IMT) index values in children with JIA. In view of the fact that atherosclerotic process begins as early as in childhood, the introduction of appropriate preventive measures in children is a matter of utmost importance.http://dx.doi.org/10.1155/2012/714732 |
| spellingShingle | Ewa Jednacz Lidia Rutkowska-Sak Atherosclerosis in Juvenile Idiopathic Arthritis Mediators of Inflammation |
| title | Atherosclerosis in Juvenile Idiopathic Arthritis |
| title_full | Atherosclerosis in Juvenile Idiopathic Arthritis |
| title_fullStr | Atherosclerosis in Juvenile Idiopathic Arthritis |
| title_full_unstemmed | Atherosclerosis in Juvenile Idiopathic Arthritis |
| title_short | Atherosclerosis in Juvenile Idiopathic Arthritis |
| title_sort | atherosclerosis in juvenile idiopathic arthritis |
| url | http://dx.doi.org/10.1155/2012/714732 |
| work_keys_str_mv | AT ewajednacz atherosclerosisinjuvenileidiopathicarthritis AT lidiarutkowskasak atherosclerosisinjuvenileidiopathicarthritis |