Hyperbaric oxygen therapy improves the effects of systemic steroid therapy for sudden sensorineural hearing loss
Objectives: This study aimed to investigate the therapeutic efficacy of combined hyperbaric oxygen therapy (HBOT) and steroid therapy in treating sudden sensorineural hearing loss (SSNHL) Design: This retrospective analysis included 505 patients diagnosed with SSNHL from August 2017 to July 2022. Th...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025004050 |
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| author | Yu-Ching Chen Yu-Hsi Liu Bor‐Hwang Kang Cai-Sin Yao Yao-Shen Chen Wen-Chung Liu |
| author_facet | Yu-Ching Chen Yu-Hsi Liu Bor‐Hwang Kang Cai-Sin Yao Yao-Shen Chen Wen-Chung Liu |
| author_sort | Yu-Ching Chen |
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| description | Objectives: This study aimed to investigate the therapeutic efficacy of combined hyperbaric oxygen therapy (HBOT) and steroid therapy in treating sudden sensorineural hearing loss (SSNHL) Design: This retrospective analysis included 505 patients diagnosed with SSNHL from August 2017 to July 2022. The patients received either a systemic steroid (SS) alone or SS with HBOT. Hearing improvement was evaluated with pure-tone audiometry (PTA). Among the participants, 102 received SS + HBOT, whereas 403 were treated with SS alone. Results: The SS + HBOT group demonstrated significantly better improvement in the PTA threshold averaged across four low frequencies (PTA4) scores (22.7 ± 23.5 vs. 16.2 ± 21.4, P = 0.007) and higher response rates (≥15 dB improvement) and significant response (≥25 dB improvement) (61.8 % vs. 44.4 %, P = 0.002; and 43.1 % vs. 22.6 %, P < 0.001, respectively) than the SS-alone group. HBOT is particularly effective in patients with hearing loss at lower frequencies. Patients treated with HBOT were 2.50 times more likely to achieve substantial hearing improvement. Patients receiving three HBOT sessions or initiating treatment within 11 days of diagnosis demonstrated optimal outcomes. Greater improvements were observed in patients with initial hearing loss of >50 dB and younger individuals. Conclusions: HBOT improves the effectiveness of SS treatment in SSNHL, with notable benefits for younger patients and those with an initial hearing loss of >50 dB. HBOT exhibited more pronounced effects at lower frequencies. Initiating HBOT within 11 days of the SSNHL diagnosis is recommended, and a regimen of five sessions is indicated for optimal results. |
| format | Article |
| id | doaj-art-3335d6acb25940cdb3be119020e566fb |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-3335d6acb25940cdb3be119020e566fb2025-02-02T05:28:49ZengElsevierHeliyon2405-84402025-01-01112e42025Hyperbaric oxygen therapy improves the effects of systemic steroid therapy for sudden sensorineural hearing lossYu-Ching Chen0Yu-Hsi Liu1Bor‐Hwang Kang2Cai-Sin Yao3Yao-Shen Chen4Wen-Chung Liu5Division of Plastic and Reconstructive Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, No.386, Dazhong 1st Rd., Zuoying Dist., Kaohsiung City, 813414, Taiwan, ROCDepartment of Otorhinolaryngology, Head & Neck Surgery, Kaohsiung Veterans General Hospital, No.386, Dazhong 1st Rd., Zuoying Dist., Kaohsiung City, 813414, Taiwan, ROC; Institute of Biomedical Science, National Sun Yat-sen University, No.70 Lien-hai Road, Kaohsiung, 804201, Taiwan, ROCDepartment of Otorhinolaryngology, Head & Neck Surgery, Kaohsiung Veterans General Hospital, No.386, Dazhong 1st Rd., Zuoying Dist., Kaohsiung City, 813414, Taiwan, ROC; Department of Pharmacy, Tajen University, No.20, Weixin Rd., Yanpu Township, Pingtung County, 907101, Taiwan, ROC; School of Medicine, National Defense Medical Center, No.161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei City, 11490, Taiwan, ROC; Department of Otolaryngology, Head and Neck Surgery, Tri-Service General Hospital, No.325, Sec.2, Chenggong Rd., Neihu District, Taipei City, 114202, Taiwan, ROCDepartment of Medical Education and Research, Kaohsiung Veterans General Hospital, No.386, Dazhong 1st Rd., Zuoying Dist., Kaohsiung City, 813414, Taiwan, ROC; Department of Business Management, National Sun Yat-sen University, No.70 Lien-hai Road, Kaohsiung, 804201, Taiwan, ROCDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Veterans General Hospital, No.386, Dazhong 1st Rd., Zuoying Dist., Kaohsiung City, 813414, Taiwan, ROCDivision of Plastic and Reconstructive Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, No.386, Dazhong 1st Rd., Zuoying Dist., Kaohsiung City, 813414, Taiwan, ROC; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City, 112304, Taiwan, ROC; School of Medicine, College of Medicine, National Sun Yat-sen University, No.70 Lien-hai Road, Kaohsiung, 804201, Taiwan, ROC; Institute for Translational Research in Biomedicine, Chang Gung Memorial Hospital, No.123, Dapi Road, Niaosong District, Kaohsiung City, 833401, Taiwan, ROC; Corresponding author. Division of Plastic and Reconstructive Surgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan. No.386, Dazhong 1st Rd., Zuoying Dist., Kaohsiung City, 813414, Taiwan, ROC.Objectives: This study aimed to investigate the therapeutic efficacy of combined hyperbaric oxygen therapy (HBOT) and steroid therapy in treating sudden sensorineural hearing loss (SSNHL) Design: This retrospective analysis included 505 patients diagnosed with SSNHL from August 2017 to July 2022. The patients received either a systemic steroid (SS) alone or SS with HBOT. Hearing improvement was evaluated with pure-tone audiometry (PTA). Among the participants, 102 received SS + HBOT, whereas 403 were treated with SS alone. Results: The SS + HBOT group demonstrated significantly better improvement in the PTA threshold averaged across four low frequencies (PTA4) scores (22.7 ± 23.5 vs. 16.2 ± 21.4, P = 0.007) and higher response rates (≥15 dB improvement) and significant response (≥25 dB improvement) (61.8 % vs. 44.4 %, P = 0.002; and 43.1 % vs. 22.6 %, P < 0.001, respectively) than the SS-alone group. HBOT is particularly effective in patients with hearing loss at lower frequencies. Patients treated with HBOT were 2.50 times more likely to achieve substantial hearing improvement. Patients receiving three HBOT sessions or initiating treatment within 11 days of diagnosis demonstrated optimal outcomes. Greater improvements were observed in patients with initial hearing loss of >50 dB and younger individuals. Conclusions: HBOT improves the effectiveness of SS treatment in SSNHL, with notable benefits for younger patients and those with an initial hearing loss of >50 dB. HBOT exhibited more pronounced effects at lower frequencies. Initiating HBOT within 11 days of the SSNHL diagnosis is recommended, and a regimen of five sessions is indicated for optimal results.http://www.sciencedirect.com/science/article/pii/S2405844025004050Sudden sensorineural hearing lossHyperbaric oxygen therapySteroidTreatment |
| spellingShingle | Yu-Ching Chen Yu-Hsi Liu Bor‐Hwang Kang Cai-Sin Yao Yao-Shen Chen Wen-Chung Liu Hyperbaric oxygen therapy improves the effects of systemic steroid therapy for sudden sensorineural hearing loss Heliyon Sudden sensorineural hearing loss Hyperbaric oxygen therapy Steroid Treatment |
| title | Hyperbaric oxygen therapy improves the effects of systemic steroid therapy for sudden sensorineural hearing loss |
| title_full | Hyperbaric oxygen therapy improves the effects of systemic steroid therapy for sudden sensorineural hearing loss |
| title_fullStr | Hyperbaric oxygen therapy improves the effects of systemic steroid therapy for sudden sensorineural hearing loss |
| title_full_unstemmed | Hyperbaric oxygen therapy improves the effects of systemic steroid therapy for sudden sensorineural hearing loss |
| title_short | Hyperbaric oxygen therapy improves the effects of systemic steroid therapy for sudden sensorineural hearing loss |
| title_sort | hyperbaric oxygen therapy improves the effects of systemic steroid therapy for sudden sensorineural hearing loss |
| topic | Sudden sensorineural hearing loss Hyperbaric oxygen therapy Steroid Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025004050 |
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