Dyslipidemia in retinal metabolic disorders
Abstract The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled by photoreceptor energy demands. It is criti...
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| Format: | Article |
| Language: | English |
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Springer Nature
2019-09-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.201910473 |
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| author | Zhongjie Fu Chuck T Chen Gael Cagnone Emilie Heckel Ye Sun Bertan Cakir Yohei Tomita Shuo Huang Qian Li William Britton Steve S Cho Timothy S Kern Ann Hellström Jean‐Sébastien Joyal Lois EH Smith |
| author_facet | Zhongjie Fu Chuck T Chen Gael Cagnone Emilie Heckel Ye Sun Bertan Cakir Yohei Tomita Shuo Huang Qian Li William Britton Steve S Cho Timothy S Kern Ann Hellström Jean‐Sébastien Joyal Lois EH Smith |
| author_sort | Zhongjie Fu |
| collection | DOAJ |
| description | Abstract The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled by photoreceptor energy demands. It is critical to understand the energy demands of photoreceptors and fuel sources supplying them to understand neurovascular diseases. Retinas are very rich in lipids, which are continuously recycled as lipid‐rich photoreceptor outer segments are shed and reformed and dietary intake of lipids modulates retinal lipid composition. Lipids (as well as glucose) are fuel substrates for photoreceptor mitochondria. Dyslipidemia contributes to the development and progression of retinal dysfunction in many eye diseases. Here, we review photoreceptor energy demands with a focus on lipid metabolism in retinal neurovascular disorders. |
| format | Article |
| id | doaj-art-3333c50737c84adcb56dde89bc82b7e9 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-3333c50737c84adcb56dde89bc82b7e92025-08-20T03:46:11ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842019-09-01111011510.15252/emmm.201910473Dyslipidemia in retinal metabolic disordersZhongjie Fu0Chuck T Chen1Gael Cagnone2Emilie Heckel3Ye Sun4Bertan Cakir5Yohei Tomita6Shuo Huang7Qian Li8William Britton9Steve S Cho10Timothy S Kern11Ann Hellström12Jean‐Sébastien Joyal13Lois EH Smith14Department of Ophthalmology, Harvard Medical School, Boston Children's HospitalNational Institute on Alcohol Abuse and Alcoholism, National Institutes of HealthDepartment of Pediatrics, Pharmacology and Ophthalmology, CHU Sainte‐Justine Research Center, Université de MontréalDepartment of Pediatrics, Pharmacology and Ophthalmology, CHU Sainte‐Justine Research Center, Université de MontréalDepartment of Ophthalmology, Harvard Medical School, Boston Children's HospitalDepartment of Ophthalmology, Harvard Medical School, Boston Children's HospitalDepartment of Ophthalmology, Harvard Medical School, Boston Children's HospitalDepartment of Ophthalmology, Harvard Medical School, Boston Children's HospitalBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical UniversityDepartment of Ophthalmology, Harvard Medical School, Boston Children's HospitalDepartment of Ophthalmology, Harvard Medical School, Boston Children's HospitalCenter for Translational Vision Research, Gavin Herbert Eye InstituteSection for Ophthalmology, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of GothenburgDepartment of Pediatrics, Pharmacology and Ophthalmology, CHU Sainte‐Justine Research Center, Université de MontréalDepartment of Ophthalmology, Harvard Medical School, Boston Children's HospitalAbstract The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled by photoreceptor energy demands. It is critical to understand the energy demands of photoreceptors and fuel sources supplying them to understand neurovascular diseases. Retinas are very rich in lipids, which are continuously recycled as lipid‐rich photoreceptor outer segments are shed and reformed and dietary intake of lipids modulates retinal lipid composition. Lipids (as well as glucose) are fuel substrates for photoreceptor mitochondria. Dyslipidemia contributes to the development and progression of retinal dysfunction in many eye diseases. Here, we review photoreceptor energy demands with a focus on lipid metabolism in retinal neurovascular disorders.https://doi.org/10.15252/emmm.201910473dyslipidemiaFGF21photoreceptorretinal metabolismβ‐oxidation |
| spellingShingle | Zhongjie Fu Chuck T Chen Gael Cagnone Emilie Heckel Ye Sun Bertan Cakir Yohei Tomita Shuo Huang Qian Li William Britton Steve S Cho Timothy S Kern Ann Hellström Jean‐Sébastien Joyal Lois EH Smith Dyslipidemia in retinal metabolic disorders EMBO Molecular Medicine dyslipidemia FGF21 photoreceptor retinal metabolism β‐oxidation |
| title | Dyslipidemia in retinal metabolic disorders |
| title_full | Dyslipidemia in retinal metabolic disorders |
| title_fullStr | Dyslipidemia in retinal metabolic disorders |
| title_full_unstemmed | Dyslipidemia in retinal metabolic disorders |
| title_short | Dyslipidemia in retinal metabolic disorders |
| title_sort | dyslipidemia in retinal metabolic disorders |
| topic | dyslipidemia FGF21 photoreceptor retinal metabolism β‐oxidation |
| url | https://doi.org/10.15252/emmm.201910473 |
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