Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2

Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2

Abstract Background Pancreatic cancer (PDAC: pancreatic ductal adenocarcinoma, the commonest form), a lethal disease, is best treated with surgical excision but is feasible in less than a fifth of patients. Around a third of patients presentlocally advanced, inoperable, non-metastatic (laPDAC), whos...

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Bibliographic Details
Main Authors: Hemant M. Kocher, BCI-STARPAC2 team, BPTB team, Precision-Panc team, Peter Sasieni, Pippa Corrie, Mairéad G. McNamara, Debashis Sarker, Fieke E. M. Froeling, Alan Christie, Roopinder Gillmore, Khurum Khan, David Propper
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Cancer
Subjects:
Locally advanced pancreatic ductal adenocarcinoma (laPDAC)
Gemcitabine and nab-paclitaxel (GEM-NABP)
All-trans-retinoic acid (ATRA)
Chemotherapy
Stroma
Progression
Online Access:https://doi.org/10.1186/s12885-024-13333-z
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