Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review
Aims. The review explores the findings of previous studies to elucidate the association between levels of D-dimer and COVID-19 severity and prognosis. In addition, we assessed the efficiency of anticoagulant therapies in reducing COVID-19 severity and improving the prognosis of the patients. Materia...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Anemia |
| Online Access: | http://dx.doi.org/10.1155/2022/9104209 |
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| author | Wesam Ahmed Nasif Abeer Shaker El-Moursy Ali Mohammed Hasan Mukhtar Aali Marzouq H. Alhuzali Yahya Ahmed Yahya Alnashri Ziyad Ishaq Ahmed Gadah Eyyad Adeeb A. Edrees Hussam Abdulaziz Mabruk Albarakati Hussam Saud Muhji Aloufi |
| author_facet | Wesam Ahmed Nasif Abeer Shaker El-Moursy Ali Mohammed Hasan Mukhtar Aali Marzouq H. Alhuzali Yahya Ahmed Yahya Alnashri Ziyad Ishaq Ahmed Gadah Eyyad Adeeb A. Edrees Hussam Abdulaziz Mabruk Albarakati Hussam Saud Muhji Aloufi |
| author_sort | Wesam Ahmed Nasif |
| collection | DOAJ |
| description | Aims. The review explores the findings of previous studies to elucidate the association between levels of D-dimer and COVID-19 severity and prognosis. In addition, we assessed the efficiency of anticoagulant therapies in reducing COVID-19 severity and improving the prognosis of the patients. Materials and Methods. A comprehensive literature review was conducted using MEDLINE/PubMed databases, Scopus, and Web of Science with the help of keywords “COVID-19,” “D-Dimer,” “Thrombosis,” “Fibrin network,” “Anticoagulant therapy,” “Inflammation,” and “disease severity.” Based on all these articles and clinical experience, a scoping review was constructed and the full texts of the articles that were retrieved were accessed. Results. A D-dimer is a complex protein molecule that is formed during plasmin-mediated degradation of the fibrin network. Thus, it serves as a marker of thrombotic activity. On the other hand, in addition to severe respiratory distress and reduction in pulmonary gas exchange, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also triggers prothrombotic changes in the infected individuals. The levels of D-dimer have been postulated to be positively associated with the degree of disease severity among COVID-19 patients. Conclusions. It has been postulated that D-dimer could potentially be used as a biomarker to predict the prognosis and outcome of COVID-19 patients at the time of admission to hospitals and facilitate more personalized and efficient clinical management that could significantly reduce the mortality rate of such patients and allow more rapid recovery. |
| format | Article |
| id | doaj-art-33243dacdb8440a18e69201d05a3cad2 |
| institution | Kabale University |
| issn | 2090-1275 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anemia |
| spelling | doaj-art-33243dacdb8440a18e69201d05a3cad22025-02-03T01:11:57ZengWileyAnemia2090-12752022-01-01202210.1155/2022/9104209Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping ReviewWesam Ahmed Nasif0Abeer Shaker El-Moursy Ali1Mohammed Hasan Mukhtar2Aali Marzouq H. Alhuzali3Yahya Ahmed Yahya Alnashri4Ziyad Ishaq Ahmed Gadah5Eyyad Adeeb A. Edrees6Hussam Abdulaziz Mabruk Albarakati7Hussam Saud Muhji Aloufi8Biochemistry DepartmentDepartment of PathologyBiochemistry DepartmentFaculty of MedicineFaculty of MedicineFaculty of MedicineFaculty of MedicineFaculty of MedicineFaculty of MedicineAims. The review explores the findings of previous studies to elucidate the association between levels of D-dimer and COVID-19 severity and prognosis. In addition, we assessed the efficiency of anticoagulant therapies in reducing COVID-19 severity and improving the prognosis of the patients. Materials and Methods. A comprehensive literature review was conducted using MEDLINE/PubMed databases, Scopus, and Web of Science with the help of keywords “COVID-19,” “D-Dimer,” “Thrombosis,” “Fibrin network,” “Anticoagulant therapy,” “Inflammation,” and “disease severity.” Based on all these articles and clinical experience, a scoping review was constructed and the full texts of the articles that were retrieved were accessed. Results. A D-dimer is a complex protein molecule that is formed during plasmin-mediated degradation of the fibrin network. Thus, it serves as a marker of thrombotic activity. On the other hand, in addition to severe respiratory distress and reduction in pulmonary gas exchange, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also triggers prothrombotic changes in the infected individuals. The levels of D-dimer have been postulated to be positively associated with the degree of disease severity among COVID-19 patients. Conclusions. It has been postulated that D-dimer could potentially be used as a biomarker to predict the prognosis and outcome of COVID-19 patients at the time of admission to hospitals and facilitate more personalized and efficient clinical management that could significantly reduce the mortality rate of such patients and allow more rapid recovery.http://dx.doi.org/10.1155/2022/9104209 |
| spellingShingle | Wesam Ahmed Nasif Abeer Shaker El-Moursy Ali Mohammed Hasan Mukhtar Aali Marzouq H. Alhuzali Yahya Ahmed Yahya Alnashri Ziyad Ishaq Ahmed Gadah Eyyad Adeeb A. Edrees Hussam Abdulaziz Mabruk Albarakati Hussam Saud Muhji Aloufi Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review Anemia |
| title | Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review |
| title_full | Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review |
| title_fullStr | Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review |
| title_full_unstemmed | Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review |
| title_short | Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review |
| title_sort | elucidating the correlation of d dimer levels with covid 19 severity a scoping review |
| url | http://dx.doi.org/10.1155/2022/9104209 |
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