Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review
Heterocyclic compounds, especially those containing the pyrazole moiety, are highly significant in organic chemistry and possess remarkable and diverse biological properties. The 5-aminopyrazole derivatives are key starting materials for the synthesis of numerous bioactive compounds such as pyrazolo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/2/366 |
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| author | Dana M. Odeh Mohanad M. Odeh Taghrid S. Hafez Ashraf S. Hassan |
| author_facet | Dana M. Odeh Mohanad M. Odeh Taghrid S. Hafez Ashraf S. Hassan |
| author_sort | Dana M. Odeh |
| collection | DOAJ |
| description | Heterocyclic compounds, especially those containing the pyrazole moiety, are highly significant in organic chemistry and possess remarkable and diverse biological properties. The 5-aminopyrazole derivatives are key starting materials for the synthesis of numerous bioactive compounds such as pyrazolopyridine, pyrazolopyrimidine, pyrazoloquinazoline, and pyrazolotriazine derivatives. Many compounds inspired by the 5-aminopyrazole derivatives possess a wide spectrum of biological activities and medicinal applications such as antioxidants, anticancer agents, enzyme inhibitors, antimicrobials, and anti-tuberculosis activities. This review summarizes the recently reported synthesis methods and biological activities of fused pyrazole and pyrazole-based derivatives based on 5-aminopyrazole compounds within the last 5 years (2020 to present). One of the important goals of this review is to illustrate future strategies for the design, development, and utilization of pyrazole products as potent drugs. |
| format | Article |
| id | doaj-art-3314b3fb5ec64309b8a74f311fd1d7de |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-3314b3fb5ec64309b8a74f311fd1d7de2025-01-24T13:43:47ZengMDPI AGMolecules1420-30492025-01-0130236610.3390/molecules30020366Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent ReviewDana M. Odeh0Mohanad M. Odeh1Taghrid S. Hafez2Ashraf S. Hassan3Department of Pharmacy, Faculty of Pharmacy, Jadara University, P.O. Box 733, Irbid 21110, JordanDepartment of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, P.O. Box 330127, Zarqa 13133, JordanOrganometallic and Organometalloid Chemistry Department, National Research Centre, Dokki, Cairo 12622, EgyptOrganometallic and Organometalloid Chemistry Department, National Research Centre, Dokki, Cairo 12622, EgyptHeterocyclic compounds, especially those containing the pyrazole moiety, are highly significant in organic chemistry and possess remarkable and diverse biological properties. The 5-aminopyrazole derivatives are key starting materials for the synthesis of numerous bioactive compounds such as pyrazolopyridine, pyrazolopyrimidine, pyrazoloquinazoline, and pyrazolotriazine derivatives. Many compounds inspired by the 5-aminopyrazole derivatives possess a wide spectrum of biological activities and medicinal applications such as antioxidants, anticancer agents, enzyme inhibitors, antimicrobials, and anti-tuberculosis activities. This review summarizes the recently reported synthesis methods and biological activities of fused pyrazole and pyrazole-based derivatives based on 5-aminopyrazole compounds within the last 5 years (2020 to present). One of the important goals of this review is to illustrate future strategies for the design, development, and utilization of pyrazole products as potent drugs.https://www.mdpi.com/1420-3049/30/2/366bioactive compounds5-aminopyrazolefused pyrazolesschiff basesdrugs |
| spellingShingle | Dana M. Odeh Mohanad M. Odeh Taghrid S. Hafez Ashraf S. Hassan Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review Molecules bioactive compounds 5-aminopyrazole fused pyrazoles schiff bases drugs |
| title | Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review |
| title_full | Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review |
| title_fullStr | Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review |
| title_full_unstemmed | Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review |
| title_short | Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review |
| title_sort | bioactive fused pyrazoles inspired by the adaptability of 5 aminopyrazole derivatives recent review |
| topic | bioactive compounds 5-aminopyrazole fused pyrazoles schiff bases drugs |
| url | https://www.mdpi.com/1420-3049/30/2/366 |
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