Desensitization: Overcoming the Immunologic Barriers to Transplantation
HLA (Human Leucocyte Antigen) sensitization is a significant barrier to successful kidney transplantation. It often translates into difficult crossmatch before transplant and increased risk of acute and chronic antibody mediated rejection after transplant. Over the last decade, several immunomodulat...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/6804678 |
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| _version_ | 1832555454375395328 |
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| author | Supreet Sethi Jua Choi Mieko Toyoda Ashley Vo Alice Peng Stanley C. Jordan |
| author_facet | Supreet Sethi Jua Choi Mieko Toyoda Ashley Vo Alice Peng Stanley C. Jordan |
| author_sort | Supreet Sethi |
| collection | DOAJ |
| description | HLA (Human Leucocyte Antigen) sensitization is a significant barrier to successful kidney transplantation. It often translates into difficult crossmatch before transplant and increased risk of acute and chronic antibody mediated rejection after transplant. Over the last decade, several immunomodulatory therapies have emerged allowing for increased access to kidney transplantation for the immunologically disadvantaged group of HLA sensitized end stage kidney disease patients. These include IgG inactivating agents, anti-cytokine antibodies, costimulatory molecule blockers, complement inhibitors, and agents targeting plasma cells. In this review, we discuss currently available agents for desensitization and provide a brief analysis of data on novel biologics, which will likely improve desensitization outcomes, and have potential implications in treatment of antibody mediated rejection. |
| format | Article |
| id | doaj-art-330dd304bdc2425caa4377bb3781c8f5 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-330dd304bdc2425caa4377bb3781c8f52025-02-03T05:48:07ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/68046786804678Desensitization: Overcoming the Immunologic Barriers to TransplantationSupreet Sethi0Jua Choi1Mieko Toyoda2Ashley Vo3Alice Peng4Stanley C. Jordan5Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAHLA (Human Leucocyte Antigen) sensitization is a significant barrier to successful kidney transplantation. It often translates into difficult crossmatch before transplant and increased risk of acute and chronic antibody mediated rejection after transplant. Over the last decade, several immunomodulatory therapies have emerged allowing for increased access to kidney transplantation for the immunologically disadvantaged group of HLA sensitized end stage kidney disease patients. These include IgG inactivating agents, anti-cytokine antibodies, costimulatory molecule blockers, complement inhibitors, and agents targeting plasma cells. In this review, we discuss currently available agents for desensitization and provide a brief analysis of data on novel biologics, which will likely improve desensitization outcomes, and have potential implications in treatment of antibody mediated rejection.http://dx.doi.org/10.1155/2017/6804678 |
| spellingShingle | Supreet Sethi Jua Choi Mieko Toyoda Ashley Vo Alice Peng Stanley C. Jordan Desensitization: Overcoming the Immunologic Barriers to Transplantation Journal of Immunology Research |
| title | Desensitization: Overcoming the Immunologic Barriers to Transplantation |
| title_full | Desensitization: Overcoming the Immunologic Barriers to Transplantation |
| title_fullStr | Desensitization: Overcoming the Immunologic Barriers to Transplantation |
| title_full_unstemmed | Desensitization: Overcoming the Immunologic Barriers to Transplantation |
| title_short | Desensitization: Overcoming the Immunologic Barriers to Transplantation |
| title_sort | desensitization overcoming the immunologic barriers to transplantation |
| url | http://dx.doi.org/10.1155/2017/6804678 |
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