Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant
Rhabdomyolysis, a syndrome of muscle necrosis, is a life-threatening event. Here we describe the case of a patient with chronic myeloid leukemia who underwent a haploidentical stem cell transplant and subsequently developed rhabdomyolysis after beginning trimethoprim-sulfamethoxazole (TMP/SMX) proph...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/619473 |
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| _version_ | 1832552697101811712 |
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| author | Alexander Augustyn Mona Lisa Alattar Harris Naina |
| author_facet | Alexander Augustyn Mona Lisa Alattar Harris Naina |
| author_sort | Alexander Augustyn |
| collection | DOAJ |
| description | Rhabdomyolysis, a syndrome of muscle necrosis, is a life-threatening event. Here we describe the case of a patient with chronic myeloid leukemia who underwent a haploidentical stem cell transplant and subsequently developed rhabdomyolysis after beginning trimethoprim-sulfamethoxazole (TMP/SMX) prophylaxis therapy. Rechallenge with TMP/SMX resulted in a repeat episode of rhabdomyolysis and confirmed the association. Withdrawal of TMP/SMX led to sustained normalization of creatine kinase levels in the patient. A high index of suspicion is necessary to identify TMP/SMX as the cause of rhabdomyolysis in immunocompromised patients. |
| format | Article |
| id | doaj-art-3303590393f740f0af9687fc839b7507 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-3303590393f740f0af9687fc839b75072025-02-03T05:58:06ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/619473619473Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell TransplantAlexander Augustyn0Mona Lisa Alattar1Harris Naina2Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USASimmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USASimmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USARhabdomyolysis, a syndrome of muscle necrosis, is a life-threatening event. Here we describe the case of a patient with chronic myeloid leukemia who underwent a haploidentical stem cell transplant and subsequently developed rhabdomyolysis after beginning trimethoprim-sulfamethoxazole (TMP/SMX) prophylaxis therapy. Rechallenge with TMP/SMX resulted in a repeat episode of rhabdomyolysis and confirmed the association. Withdrawal of TMP/SMX led to sustained normalization of creatine kinase levels in the patient. A high index of suspicion is necessary to identify TMP/SMX as the cause of rhabdomyolysis in immunocompromised patients.http://dx.doi.org/10.1155/2015/619473 |
| spellingShingle | Alexander Augustyn Mona Lisa Alattar Harris Naina Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant Case Reports in Oncological Medicine |
| title | Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant |
| title_full | Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant |
| title_fullStr | Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant |
| title_full_unstemmed | Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant |
| title_short | Rhabdomyolysis due to Trimethoprim-Sulfamethoxazole Administration following a Hematopoietic Stem Cell Transplant |
| title_sort | rhabdomyolysis due to trimethoprim sulfamethoxazole administration following a hematopoietic stem cell transplant |
| url | http://dx.doi.org/10.1155/2015/619473 |
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