Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy
Stem cell-based therapy has emerged as a promising approach for heart repair, potentially regenerating damaged heart tissue and improving outcomes for patients with heart disease. However, the efficacy of stem cell-based therapies remains limited by several challenges, including poor cell survival,...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000341 |
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| author | Chuanfeng An Yuan Zhao Lipeng Guo Zhijian Zhang Chunxiao Yan Shiying Zhang Yujie Zhang Fei Shao Yuanyuan Qi Xun wang Huanan Wang Lijun Zhang |
| author_facet | Chuanfeng An Yuan Zhao Lipeng Guo Zhijian Zhang Chunxiao Yan Shiying Zhang Yujie Zhang Fei Shao Yuanyuan Qi Xun wang Huanan Wang Lijun Zhang |
| author_sort | Chuanfeng An |
| collection | DOAJ |
| description | Stem cell-based therapy has emerged as a promising approach for heart repair, potentially regenerating damaged heart tissue and improving outcomes for patients with heart disease. However, the efficacy of stem cell-based therapies remains limited by several challenges, including poor cell survival, low retention rates, poor integration, and limited functional outcomes. This article reviews current enhancement strategies to optimize mesenchymal stem cell therapy for cardiac repair. Key approaches include optimizing cell delivery methods, enhancing cell engraftment, promoting cell functions through genetic and molecular modifications, enhancing the paracrine effects of stem cells, and leveraging biomaterials and tissue engineering techniques. By focusing on these enhancement techniques, the paper highlights innovative approaches that can potentially transform stem cell therapy into a more viable and effective treatment option for cardiac repair. The ongoing research and technological advancements continue to push the boundaries, hoping to make stem cell therapy a mainstream treatment for heart disease. |
| format | Article |
| id | doaj-art-32f2470b40414e9f8a8cf3e151766a58 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-32f2470b40414e9f8a8cf3e151766a582025-01-18T05:05:08ZengElsevierMaterials Today Bio2590-00642025-04-0131101476Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapyChuanfeng An0Yuan Zhao1Lipeng Guo2Zhijian Zhang3Chunxiao Yan4Shiying Zhang5Yujie Zhang6Fei Shao7Yuanyuan Qi8Xun wang9Huanan Wang10Lijun Zhang11Ophthalmology and Transformational Innovation Research Center, Faculty of Medicine of Dalian University of Technology&Dalian Third People's Hospital, Dalian, 116033, PR China; Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian, 116033, PR China; Corresponding author. Ophthalmology and Transformational Innovation Research Center, Faculty of Medicine of Dalian.MOE Key Laboratory of Bio-Intelligent Manufacturing, Dalian Key Laboratory of Artificial Organ and Regenerative Medicine, School of Bioengineering, Dalian University of Technology, Liaoning, Dalian, 116024, PR ChinaOphthalmology and Transformational Innovation Research Center, Faculty of Medicine of Dalian University of Technology&Dalian Third People's Hospital, Dalian, 116033, PR China; Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian, 116033, PR ChinaDepartment of Ophthalmology, Third People's Hospital of Dalian, Dalian Medical University, Dalian, 116033, PR ChinaDepartment of Ophthalmology, Third People's Hospital of Dalian, Dalian Medical University, Dalian, 116033, PR ChinaSchool of Dentistry, Shenzhen University, Shenzhen, 518060, PR ChinaMOE Key Laboratory of Bio-Intelligent Manufacturing, Dalian Key Laboratory of Artificial Organ and Regenerative Medicine, School of Bioengineering, Dalian University of Technology, Liaoning, Dalian, 116024, PR ChinaMOE Key Laboratory of Bio-Intelligent Manufacturing, Dalian Key Laboratory of Artificial Organ and Regenerative Medicine, School of Bioengineering, Dalian University of Technology, Liaoning, Dalian, 116024, PR ChinaOphthalmology and Transformational Innovation Research Center, Faculty of Medicine of Dalian University of Technology&Dalian Third People's Hospital, Dalian, 116033, PR China; Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian, 116033, PR ChinaOphthalmology and Transformational Innovation Research Center, Faculty of Medicine of Dalian University of Technology&Dalian Third People's Hospital, Dalian, 116033, PR China; Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian, 116033, PR China; Corresponding author. Ophthalmology and Transformational Innovation Research Center, Faculty of Medicine of Dalian.MOE Key Laboratory of Bio-Intelligent Manufacturing, Dalian Key Laboratory of Artificial Organ and Regenerative Medicine, School of Bioengineering, Dalian University of Technology, Liaoning, Dalian, 116024, PR China; Corresponding author.Ophthalmology and Transformational Innovation Research Center, Faculty of Medicine of Dalian University of Technology&Dalian Third People's Hospital, Dalian, 116033, PR China; Third People's Hospital of Dalian, Dalian Eye Hospital, Dalian, 116033, PR China; Corresponding author. Ophthalmology and Transformational Innovation Research Center, Faculty of Medicine of Dalian.Stem cell-based therapy has emerged as a promising approach for heart repair, potentially regenerating damaged heart tissue and improving outcomes for patients with heart disease. However, the efficacy of stem cell-based therapies remains limited by several challenges, including poor cell survival, low retention rates, poor integration, and limited functional outcomes. This article reviews current enhancement strategies to optimize mesenchymal stem cell therapy for cardiac repair. Key approaches include optimizing cell delivery methods, enhancing cell engraftment, promoting cell functions through genetic and molecular modifications, enhancing the paracrine effects of stem cells, and leveraging biomaterials and tissue engineering techniques. By focusing on these enhancement techniques, the paper highlights innovative approaches that can potentially transform stem cell therapy into a more viable and effective treatment option for cardiac repair. The ongoing research and technological advancements continue to push the boundaries, hoping to make stem cell therapy a mainstream treatment for heart disease.http://www.sciencedirect.com/science/article/pii/S2590006425000341 |
| spellingShingle | Chuanfeng An Yuan Zhao Lipeng Guo Zhijian Zhang Chunxiao Yan Shiying Zhang Yujie Zhang Fei Shao Yuanyuan Qi Xun wang Huanan Wang Lijun Zhang Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy Materials Today Bio |
| title | Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy |
| title_full | Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy |
| title_fullStr | Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy |
| title_full_unstemmed | Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy |
| title_short | Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy |
| title_sort | innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000341 |
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