Case report: Persistent syndrome of inappropriate antidiuresis after traumatic brain injury: spontaneous resolution and impact on RAAS and bone metabolism over five years
The syndrome of Inappropriate Antidiuresis (SIAD) is a well-known cause of hyponatremia and can be associated with various etiologies, including traumatic brain injury (TBI). Most cases of SIAD following TBI exhibit a pattern in which hyponatremia develops several days to weeks after the trauma and...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1509060/full |
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| author | Yaoxia Liu Jiao Tang Jiao Tang Jiao Tang Mingwei Zhou Haotian Huang Tao Wang Tao Wang Min Zhang |
| author_facet | Yaoxia Liu Jiao Tang Jiao Tang Jiao Tang Mingwei Zhou Haotian Huang Tao Wang Tao Wang Min Zhang |
| author_sort | Yaoxia Liu |
| collection | DOAJ |
| description | The syndrome of Inappropriate Antidiuresis (SIAD) is a well-known cause of hyponatremia and can be associated with various etiologies, including traumatic brain injury (TBI). Most cases of SIAD following TBI exhibit a pattern in which hyponatremia develops several days to weeks after the trauma and resolves within a few weeks. Here, we present a rare case of persistent SIAD caused by TBI that resolved spontaneously after five years. The patient experienced prolonged hyponatremia for several years and was ultimately diagnosed with post-traumatic SIAD after excluding other potential causes. Notably, the patient exhibited an unusual sensitivity to tolvaptan, accompanied by decreased renin levels and increased bone turnover markers. The condition resolved spontaneously after five years, with renin, aldosterone, and bone turnover markers returning to normal upon re-evaluation. |
| format | Article |
| id | doaj-art-32efd60dd9cf4d79be11c7d24be60663 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-32efd60dd9cf4d79be11c7d24be606632025-01-24T05:21:21ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.15090601509060Case report: Persistent syndrome of inappropriate antidiuresis after traumatic brain injury: spontaneous resolution and impact on RAAS and bone metabolism over five yearsYaoxia Liu0Jiao Tang1Jiao Tang2Jiao Tang3Mingwei Zhou4Haotian Huang5Tao Wang6Tao Wang7Min Zhang8Department of Geriatric Endocrinology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaDepartment of Pediatrics, The First People’s Hospital of Longquanyi District, Chengdu, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaDepartment of Geriatric Endocrinology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaThe syndrome of Inappropriate Antidiuresis (SIAD) is a well-known cause of hyponatremia and can be associated with various etiologies, including traumatic brain injury (TBI). Most cases of SIAD following TBI exhibit a pattern in which hyponatremia develops several days to weeks after the trauma and resolves within a few weeks. Here, we present a rare case of persistent SIAD caused by TBI that resolved spontaneously after five years. The patient experienced prolonged hyponatremia for several years and was ultimately diagnosed with post-traumatic SIAD after excluding other potential causes. Notably, the patient exhibited an unusual sensitivity to tolvaptan, accompanied by decreased renin levels and increased bone turnover markers. The condition resolved spontaneously after five years, with renin, aldosterone, and bone turnover markers returning to normal upon re-evaluation.https://www.frontiersin.org/articles/10.3389/fendo.2024.1509060/fullSIADhyponatremiatraumatic brain injury (TBI)tolvaptanrenin-angiotensin-aldosterone system (RAAS)bone metabolism |
| spellingShingle | Yaoxia Liu Jiao Tang Jiao Tang Jiao Tang Mingwei Zhou Haotian Huang Tao Wang Tao Wang Min Zhang Case report: Persistent syndrome of inappropriate antidiuresis after traumatic brain injury: spontaneous resolution and impact on RAAS and bone metabolism over five years Frontiers in Endocrinology SIAD hyponatremia traumatic brain injury (TBI) tolvaptan renin-angiotensin-aldosterone system (RAAS) bone metabolism |
| title | Case report: Persistent syndrome of inappropriate antidiuresis after traumatic brain injury: spontaneous resolution and impact on RAAS and bone metabolism over five years |
| title_full | Case report: Persistent syndrome of inappropriate antidiuresis after traumatic brain injury: spontaneous resolution and impact on RAAS and bone metabolism over five years |
| title_fullStr | Case report: Persistent syndrome of inappropriate antidiuresis after traumatic brain injury: spontaneous resolution and impact on RAAS and bone metabolism over five years |
| title_full_unstemmed | Case report: Persistent syndrome of inappropriate antidiuresis after traumatic brain injury: spontaneous resolution and impact on RAAS and bone metabolism over five years |
| title_short | Case report: Persistent syndrome of inappropriate antidiuresis after traumatic brain injury: spontaneous resolution and impact on RAAS and bone metabolism over five years |
| title_sort | case report persistent syndrome of inappropriate antidiuresis after traumatic brain injury spontaneous resolution and impact on raas and bone metabolism over five years |
| topic | SIAD hyponatremia traumatic brain injury (TBI) tolvaptan renin-angiotensin-aldosterone system (RAAS) bone metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1509060/full |
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