The Diagnostic Role of Serum Inflammatory and Soluble Proteins on Dementia Subtypes: Correlation with Cognitive and Functional Decline
In the past years, the possible involvement of inflammation in the pathogenesis of dementia has been the subject of several investigations. However there are restricted data about the profile of the inflammatory and soluble proteins in well evaluated Alzheimer’s disease (AD), vascular dementia (VD),...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2007/432190 |
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| author | Candan Öztürk Aynur Özge Osman Özgür Yalın İ. Arda Yılmaz Nuran Delialioglu Çilem Yıldız Bahar Tesdelen Cigdem Kudiaki |
| author_facet | Candan Öztürk Aynur Özge Osman Özgür Yalın İ. Arda Yılmaz Nuran Delialioglu Çilem Yıldız Bahar Tesdelen Cigdem Kudiaki |
| author_sort | Candan Öztürk |
| collection | DOAJ |
| description | In the past years, the possible involvement of inflammation in the pathogenesis of dementia has been the subject of several investigations. However there are restricted data about the profile of the inflammatory and soluble proteins in well evaluated Alzheimer’s disease (AD), vascular dementia (VD), mild cognitive impairment (MCI) and healthy controls. There are also no reliable data regarding the relationship between the overlapping protein levels and cognitive or functional decline. We measured levels of IL-1β, IL-2, IL-6, IL-18, TNF-α, β-Amlyloid 1–40 and α1-antichymotrypsin levels in plasma in groups of total 82 subjects with AD, MCI, VD and controls using enzyme-linked immunosorbent assay (ELISA) method. Our study samples showed high levels of proinflammatory cytokine levels (especially IL-18) in all patient groups but only high levels of α1-antichymotrypsine in VD patients compared to controls. There is no significant correlation between the laboratory and clinical variables except for a link between IL-1β and NPI scores of AD. In conclusion, this study yielded evidence of some shared mechanisms underlying AD and VD and thus motivates further studies of inflammatory markers in various types of dementia and MCI. |
| format | Article |
| id | doaj-art-32efa0c0641f4a00b64741798d5fe10b |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-32efa0c0641f4a00b64741798d5fe10b2025-02-03T01:00:29ZengWileyBehavioural Neurology0953-41801875-85842007-01-0118420721510.1155/2007/432190The Diagnostic Role of Serum Inflammatory and Soluble Proteins on Dementia Subtypes: Correlation with Cognitive and Functional DeclineCandan Öztürk0Aynur Özge1Osman Özgür Yalın2İ. Arda Yılmaz3Nuran Delialioglu4Çilem Yıldız5Bahar Tesdelen6Cigdem Kudiaki7Mersin University School of Medicine and Mersin University School of Science and Letters, Mersin, TurkeyMersin University School of Medicine and Mersin University School of Science and Letters, Mersin, TurkeyMersin University School of Medicine and Mersin University School of Science and Letters, Mersin, TurkeyMersin University School of Medicine and Mersin University School of Science and Letters, Mersin, TurkeyMersin University School of Medicine and Mersin University School of Science and Letters, Mersin, TurkeyMersin University School of Medicine and Mersin University School of Science and Letters, Mersin, TurkeyMersin University School of Medicine and Mersin University School of Science and Letters, Mersin, TurkeyMersin University School of Medicine and Mersin University School of Science and Letters, Mersin, TurkeyIn the past years, the possible involvement of inflammation in the pathogenesis of dementia has been the subject of several investigations. However there are restricted data about the profile of the inflammatory and soluble proteins in well evaluated Alzheimer’s disease (AD), vascular dementia (VD), mild cognitive impairment (MCI) and healthy controls. There are also no reliable data regarding the relationship between the overlapping protein levels and cognitive or functional decline. We measured levels of IL-1β, IL-2, IL-6, IL-18, TNF-α, β-Amlyloid 1–40 and α1-antichymotrypsin levels in plasma in groups of total 82 subjects with AD, MCI, VD and controls using enzyme-linked immunosorbent assay (ELISA) method. Our study samples showed high levels of proinflammatory cytokine levels (especially IL-18) in all patient groups but only high levels of α1-antichymotrypsine in VD patients compared to controls. There is no significant correlation between the laboratory and clinical variables except for a link between IL-1β and NPI scores of AD. In conclusion, this study yielded evidence of some shared mechanisms underlying AD and VD and thus motivates further studies of inflammatory markers in various types of dementia and MCI.http://dx.doi.org/10.1155/2007/432190 |
| spellingShingle | Candan Öztürk Aynur Özge Osman Özgür Yalın İ. Arda Yılmaz Nuran Delialioglu Çilem Yıldız Bahar Tesdelen Cigdem Kudiaki The Diagnostic Role of Serum Inflammatory and Soluble Proteins on Dementia Subtypes: Correlation with Cognitive and Functional Decline Behavioural Neurology |
| title | The Diagnostic Role of Serum Inflammatory and Soluble Proteins on Dementia Subtypes: Correlation with Cognitive and Functional Decline |
| title_full | The Diagnostic Role of Serum Inflammatory and Soluble Proteins on Dementia Subtypes: Correlation with Cognitive and Functional Decline |
| title_fullStr | The Diagnostic Role of Serum Inflammatory and Soluble Proteins on Dementia Subtypes: Correlation with Cognitive and Functional Decline |
| title_full_unstemmed | The Diagnostic Role of Serum Inflammatory and Soluble Proteins on Dementia Subtypes: Correlation with Cognitive and Functional Decline |
| title_short | The Diagnostic Role of Serum Inflammatory and Soluble Proteins on Dementia Subtypes: Correlation with Cognitive and Functional Decline |
| title_sort | diagnostic role of serum inflammatory and soluble proteins on dementia subtypes correlation with cognitive and functional decline |
| url | http://dx.doi.org/10.1155/2007/432190 |
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