Mutational accumulation drives pathway dysregulation to predict glioma patient survival

Abstract Previous studies majorly focused on the role of driver gene variation in the occurrence, development and treatment of glioma. Here, we revealed the effect of signaling pathway abnormality by accumulated genetic mutations on patient survival and explored potential mechanism in glioma. We fou...

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Bibliographic Details
Main Authors: Mengjiao Wan, Caiping Zhuang, Wei Li, Rongrong Yan, Wen Chen, Jing Cheng, Chengjin Yue, Lin Chen, Yingyao Quan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-12346-3
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