Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized controlled pilot study

Effect of a high dose atorvastatin as adjuvant therapy to mesalamine in attenuating inflammation and symptoms in patients with ulcerative colitis: a randomized controlled pilot study

BackgroundUlcerative colitis (UC) is a chronic inflammatory disorder of the colon. Several preclinical studies investigated the beneficial effects of atorvastatin in colitis. Activation of sphingosine 1 phosphate (S1P)/ tumor necrosis factor-alpha (TNF-α)/ interleukin-6 (IL-6) pathways has been conf...

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Bibliographic Details
Main Authors: Sumaiah J. Alarfaj, Sahar M. El-Haggar, Sahar K. Hegazy, Maha M. Maher, Monir M. Bahgat, Thanaa A. Elmasry, Sarah Alrubia, Amsha S. Alsegiani, Mostafa M. Bahaa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Medicine
Subjects:
atorvastatin
calprotectin
oxidative stress
S1P
ulcerative colitis
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2024.1490178/full
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