Immunomediated Encephalitis: New Diagnoses on the Neurology–Psychiatry Interface
Immune-mediated encephalitis is a real diagnostic challenge. Initially, patients present with subacute behavioral alterations, evolving over months, being attributed to purely psychiatric mechanisms, as well as neurological symptoms that often go unnoticed by professionals who are not neurologists....
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
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| Series: | Brazilian Neurosurgery |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1801860 |
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| author | Daniel Damiani Aline Ribeiro de Bem |
| author_facet | Daniel Damiani Aline Ribeiro de Bem |
| author_sort | Daniel Damiani |
| collection | DOAJ |
| description | Immune-mediated encephalitis is a real diagnostic challenge. Initially, patients present with subacute behavioral alterations, evolving over months, being attributed to purely psychiatric mechanisms, as well as neurological symptoms that often go unnoticed by professionals who are not neurologists. The etiologies behind these diseases are represented by paraneoplastic syndromes (including occult tumors) as well as viral infections, in both cases constituting true immunological triggers with exposure of antigens that will lead to a cross-immunological response directed at healthy structures of the nervous system. In the current review, we present the different clinical scenarios which differ based on antibodies against membrane receptors described so far, emphasizing the relevance of an early diagnosis for a smaller impact on prognosis. |
| format | Article |
| id | doaj-art-32e7a7fd907a4ccd959b8bce1b33cc93 |
| institution | Kabale University |
| issn | 0103-5355 2359-5922 |
| language | English |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Brazilian Neurosurgery |
| spelling | doaj-art-32e7a7fd907a4ccd959b8bce1b33cc932025-01-31T23:53:48ZengThieme Revinter Publicações Ltda.Brazilian Neurosurgery0103-53552359-592210.1055/s-0045-1801860Immunomediated Encephalitis: New Diagnoses on the Neurology–Psychiatry InterfaceDaniel Damiani0https://orcid.org/0000-0001-5786-0923Aline Ribeiro de Bem1Department of Neurology, School of Medicine, Universidade Cidade de São Paulo (UNICID), São Paulo, SP, BrazilDepartment of Neurology, School of Medicine, Universidade Cidade de São Paulo (UNICID), São Paulo, SP, BrazilImmune-mediated encephalitis is a real diagnostic challenge. Initially, patients present with subacute behavioral alterations, evolving over months, being attributed to purely psychiatric mechanisms, as well as neurological symptoms that often go unnoticed by professionals who are not neurologists. The etiologies behind these diseases are represented by paraneoplastic syndromes (including occult tumors) as well as viral infections, in both cases constituting true immunological triggers with exposure of antigens that will lead to a cross-immunological response directed at healthy structures of the nervous system. In the current review, we present the different clinical scenarios which differ based on antibodies against membrane receptors described so far, emphasizing the relevance of an early diagnosis for a smaller impact on prognosis.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1801860encephalitisautoimmune encephalitisantibody-mediated encephalitislimbic encephalitisencefaliteencefalites autoimuneencefalite mediada por anticorposencefalite límbica |
| spellingShingle | Daniel Damiani Aline Ribeiro de Bem Immunomediated Encephalitis: New Diagnoses on the Neurology–Psychiatry Interface Brazilian Neurosurgery encephalitis autoimmune encephalitis antibody-mediated encephalitis limbic encephalitis encefalite encefalites autoimune encefalite mediada por anticorpos encefalite límbica |
| title | Immunomediated Encephalitis: New Diagnoses on the Neurology–Psychiatry Interface |
| title_full | Immunomediated Encephalitis: New Diagnoses on the Neurology–Psychiatry Interface |
| title_fullStr | Immunomediated Encephalitis: New Diagnoses on the Neurology–Psychiatry Interface |
| title_full_unstemmed | Immunomediated Encephalitis: New Diagnoses on the Neurology–Psychiatry Interface |
| title_short | Immunomediated Encephalitis: New Diagnoses on the Neurology–Psychiatry Interface |
| title_sort | immunomediated encephalitis new diagnoses on the neurology psychiatry interface |
| topic | encephalitis autoimmune encephalitis antibody-mediated encephalitis limbic encephalitis encefalite encefalites autoimune encefalite mediada por anticorpos encefalite límbica |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1801860 |
| work_keys_str_mv | AT danieldamiani immunomediatedencephalitisnewdiagnosesontheneurologypsychiatryinterface AT alineribeirodebem immunomediatedencephalitisnewdiagnosesontheneurologypsychiatryinterface |