CAR-T therapy toxicities: the importance of macrophages in their development and possible targets for their management

Abstract CAR-T cell therapies have risen to prominence over the last decade, and their indications are increasing with several products approved as early as second line in Large B Cell non-Hodgkin Lymphomas. Their major toxicities are the cytokine release syndrome (CRS) and the Immune-effector Cell...

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Bibliographic Details
Main Authors: Joseph Norton, Patrick Stiff
Format: Article
Language:English
Published: Springer 2025-01-01
Series:Discover Oncology
Online Access:https://doi.org/10.1007/s12672-025-01776-0
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