Utilisation of High Molecular Weight and Ultra-High Molecular Weight Hyaluronan in Management of Glioblastoma
HA (hyaluronan) has been considered in recent years as a naturally occurring modifiable gel-like scaffold that has the capability to absorb and release drugs over an extended period of time making it suitable as a potential chemotherapeutic delivery agent. Considering the limited treatment options a...
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MDPI AG
2025-01-01
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| author | Alex-Adrian Salagean Cezara-Anca-Denisa Moldovan Mark Slevin |
| author_facet | Alex-Adrian Salagean Cezara-Anca-Denisa Moldovan Mark Slevin |
| author_sort | Alex-Adrian Salagean |
| collection | DOAJ |
| description | HA (hyaluronan) has been considered in recent years as a naturally occurring modifiable gel-like scaffold that has the capability to absorb and release drugs over an extended period of time making it suitable as a potential chemotherapeutic delivery agent. Considering the limited treatment options available in the treatment of glioblastoma, in this review, we discuss the novel utilisation of ultra-high molecular weight HA—originally identified as a mechanism for maintaining longevity in the naked mole-rat—as both a protective and extracellular matrix-optimizing colloidal scaffold, and a means to deliver therapy in resected brain tumours. The unique properties of this unique form of HA cross-linked gel indicate potential future use in the prevention and treatment of both proliferative-based and inflammation-driven disease. |
| format | Article |
| id | doaj-art-32c8a965fa88450288a05f455e84541b |
| institution | Kabale University |
| issn | 2310-2861 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-32c8a965fa88450288a05f455e84541b2025-01-24T13:33:55ZengMDPI AGGels2310-28612025-01-011115010.3390/gels11010050Utilisation of High Molecular Weight and Ultra-High Molecular Weight Hyaluronan in Management of GlioblastomaAlex-Adrian Salagean0Cezara-Anca-Denisa Moldovan1Mark Slevin2Department of Histology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540142 Târgu Mureș, RomaniaSchool of Medicine, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540142 Târgu Mureș, RomaniaCenter for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540142 Târgu Mureș, RomaniaHA (hyaluronan) has been considered in recent years as a naturally occurring modifiable gel-like scaffold that has the capability to absorb and release drugs over an extended period of time making it suitable as a potential chemotherapeutic delivery agent. Considering the limited treatment options available in the treatment of glioblastoma, in this review, we discuss the novel utilisation of ultra-high molecular weight HA—originally identified as a mechanism for maintaining longevity in the naked mole-rat—as both a protective and extracellular matrix-optimizing colloidal scaffold, and a means to deliver therapy in resected brain tumours. The unique properties of this unique form of HA cross-linked gel indicate potential future use in the prevention and treatment of both proliferative-based and inflammation-driven disease.https://www.mdpi.com/2310-2861/11/1/50naked mole-rathyaluronanglioblastomatargeted drug delivery |
| spellingShingle | Alex-Adrian Salagean Cezara-Anca-Denisa Moldovan Mark Slevin Utilisation of High Molecular Weight and Ultra-High Molecular Weight Hyaluronan in Management of Glioblastoma Gels naked mole-rat hyaluronan glioblastoma targeted drug delivery |
| title | Utilisation of High Molecular Weight and Ultra-High Molecular Weight Hyaluronan in Management of Glioblastoma |
| title_full | Utilisation of High Molecular Weight and Ultra-High Molecular Weight Hyaluronan in Management of Glioblastoma |
| title_fullStr | Utilisation of High Molecular Weight and Ultra-High Molecular Weight Hyaluronan in Management of Glioblastoma |
| title_full_unstemmed | Utilisation of High Molecular Weight and Ultra-High Molecular Weight Hyaluronan in Management of Glioblastoma |
| title_short | Utilisation of High Molecular Weight and Ultra-High Molecular Weight Hyaluronan in Management of Glioblastoma |
| title_sort | utilisation of high molecular weight and ultra high molecular weight hyaluronan in management of glioblastoma |
| topic | naked mole-rat hyaluronan glioblastoma targeted drug delivery |
| url | https://www.mdpi.com/2310-2861/11/1/50 |
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