Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses
In recent years, the use of nanotechnologies to improve immunotherapy efficiency has attracted increasing interest in preventive and therapeutic cancer vaccine design. However, current nanocarriers are restricted by difficulties in the systematic spatial coordinative transport of antigens, which gre...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2025-01-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266732582300122X |
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| author | Liping Liu Jiayu Zhao Zichao Huang Yudi Xu Hongyu Chen Ruirui Qiao Wantong Song Zhaohui Tang Thomas P. Davis Xuesi Chen |
| author_facet | Liping Liu Jiayu Zhao Zichao Huang Yudi Xu Hongyu Chen Ruirui Qiao Wantong Song Zhaohui Tang Thomas P. Davis Xuesi Chen |
| author_sort | Liping Liu |
| collection | DOAJ |
| description | In recent years, the use of nanotechnologies to improve immunotherapy efficiency has attracted increasing interest in preventive and therapeutic cancer vaccine design. However, current nanocarriers are restricted by difficulties in the systematic spatial coordinative transport of antigens, which greatly hampers the immune response efficacy of nanovaccines. Herein, we designed a mannan-decorated stimulator of the interferon genes (STING)-activating vaccine carrier for spatial coordinative stimulation of antigen-specific immune responses and elicitation of robust antitumor immunity. Mannan-decoration as the shell could significantly enhance the lymph node draining ability of the nanovaccines, especially in CD8+ dendritic cells (DCs). Azole molecule end-capped polylactic acid-polyethylenimine (PLA-PEI-4BImi) with innate stimulating activity was applied as the inner core for coordinating antigen-presenting cell activation and antigen cross-presentation. In the in vivo therapy study, single usage of this nanovaccine could achieve a 93% tumor suppression rate in the B16-OVA tumor model, which is superior to the commercialized aluminum adjuvant. This study demonstrates that a rational design of vaccine carriers for solving spatial transmission issues could greatly improve cancer vaccine efficiencies. |
| format | Article |
| id | doaj-art-32afaaa1dfa14ab4a88eed8b780412da |
| institution | Kabale University |
| issn | 2667-3258 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-32afaaa1dfa14ab4a88eed8b780412da2025-01-29T05:02:32ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582025-01-0151183191Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responsesLiping Liu0Jiayu Zhao1Zichao Huang2Yudi Xu3Hongyu Chen4Ruirui Qiao5Wantong Song6Zhaohui Tang7Thomas P. Davis8Xuesi Chen9Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Science and Technology of China, Hefei 230026, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Science and Technology of China, Hefei 230026, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Science and Technology of China, Hefei 230026, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Science and Technology of China, Hefei 230026, ChinaAustralian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland 4072, AustraliaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Science and Technology of China, Hefei 230026, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China; Corresponding authors.Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Science and Technology of China, Hefei 230026, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, China; Corresponding authors.Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland 4072, AustraliaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; University of Science and Technology of China, Hefei 230026, China; Jilin Biomedical Polymers Engineering Laboratory, Changchun 130022, ChinaIn recent years, the use of nanotechnologies to improve immunotherapy efficiency has attracted increasing interest in preventive and therapeutic cancer vaccine design. However, current nanocarriers are restricted by difficulties in the systematic spatial coordinative transport of antigens, which greatly hampers the immune response efficacy of nanovaccines. Herein, we designed a mannan-decorated stimulator of the interferon genes (STING)-activating vaccine carrier for spatial coordinative stimulation of antigen-specific immune responses and elicitation of robust antitumor immunity. Mannan-decoration as the shell could significantly enhance the lymph node draining ability of the nanovaccines, especially in CD8+ dendritic cells (DCs). Azole molecule end-capped polylactic acid-polyethylenimine (PLA-PEI-4BImi) with innate stimulating activity was applied as the inner core for coordinating antigen-presenting cell activation and antigen cross-presentation. In the in vivo therapy study, single usage of this nanovaccine could achieve a 93% tumor suppression rate in the B16-OVA tumor model, which is superior to the commercialized aluminum adjuvant. This study demonstrates that a rational design of vaccine carriers for solving spatial transmission issues could greatly improve cancer vaccine efficiencies.http://www.sciencedirect.com/science/article/pii/S266732582300122XCancer immunotherapyCancer vaccineNanotechnologyDrug deliveryBiopolymer |
| spellingShingle | Liping Liu Jiayu Zhao Zichao Huang Yudi Xu Hongyu Chen Ruirui Qiao Wantong Song Zhaohui Tang Thomas P. Davis Xuesi Chen Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses Fundamental Research Cancer immunotherapy Cancer vaccine Nanotechnology Drug delivery Biopolymer |
| title | Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses |
| title_full | Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses |
| title_fullStr | Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses |
| title_full_unstemmed | Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses |
| title_short | Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses |
| title_sort | mannan decorated sting activating vaccine carrier for spatial coordinative stimulating antigen specific immune responses |
| topic | Cancer immunotherapy Cancer vaccine Nanotechnology Drug delivery Biopolymer |
| url | http://www.sciencedirect.com/science/article/pii/S266732582300122X |
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