Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells
Early and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT). This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of aut...
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| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/282147 |
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| author | Francesco Orio Giovanna Muscogiuri Stefano Palomba Bianca Serio Mariarosaria Sessa Valentina Giudice Idalucia Ferrara Libuse Tauchmanovà Annamaria Colao Carmine Selleri |
| author_facet | Francesco Orio Giovanna Muscogiuri Stefano Palomba Bianca Serio Mariarosaria Sessa Valentina Giudice Idalucia Ferrara Libuse Tauchmanovà Annamaria Colao Carmine Selleri |
| author_sort | Francesco Orio |
| collection | DOAJ |
| description | Early and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT). This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of auto- and allo-HSCT and outlines current options for their management. Gonadal impairment has been found early in approximately two-thirds of auto- and allo-HSCT patients: 90–99% of women and 60–90% of men. Dysfunctions of the hypothalamus-pituitary-growth hormone/insulin growth factor-I axis, hypothalamus-pituitary-thyroid axis, and hypothalamus-pituitary-adrenal axis were documented as later complicances, occurring in about 10, 30, and 40–50% of transplanted patients, respectively. Moreover, overt or subclinical thyroid complications (including persistent low-T3 syndrome, chronic thyroiditis, subclinical hypo- or hyperthyroidism, and thyroid carcinoma), gonadal failure, and adrenal insufficiency may persist many years after HSCT. Our analysis further provides evidence that main recognized risk factors for endocrine complications after HSCT are the underlying disease, previous pretransplant therapies, the age at HSCT, gender, total body irradiation, posttransplant derangement of immune system, and in the allogeneic setting, the presence of graft-versus-host disease requiring prolonged steroid treatment. Early identification of endocrine complications can greatly improve the quality of life of long-term survivors after HSCT. |
| format | Article |
| id | doaj-art-328e9c778dbd49598497e471e7f64787 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-328e9c778dbd49598497e471e7f647872025-02-03T01:33:24ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/282147282147Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem CellsFrancesco Orio0Giovanna Muscogiuri1Stefano Palomba2Bianca Serio3Mariarosaria Sessa4Valentina Giudice5Idalucia Ferrara6Libuse Tauchmanovà7Annamaria Colao8Carmine Selleri9Department of Sports Science and Wellness, University “Parthenope” Naples, 80133 Naples, ItalyDepartment of Clinical Medicine and Surgery, University Federico II Naples, 80131 Naples, ItalyUnit of Obstetrics and Gynaecology, “Arcispedale Santa Maria Nuova”, IRCCS, 42123 Reggio Emilia, ItalyHematology and Hematopoietic Stem Cell Transplant Center, Department of Medicine and Surgery, University of Salerno, 84131 Salerno, ItalyHematology and Hematopoietic Stem Cell Transplant Center, Department of Medicine and Surgery, University of Salerno, 84131 Salerno, ItalyHematology and Hematopoietic Stem Cell Transplant Center, Department of Medicine and Surgery, University of Salerno, 84131 Salerno, ItalyHematology and Hematopoietic Stem Cell Transplant Center, Department of Medicine and Surgery, University of Salerno, 84131 Salerno, ItalyHematology and Hematopoietic Stem Cell Transplant Center, Department of Medicine and Surgery, University of Salerno, 84131 Salerno, ItalyDepartment of Clinical Medicine and Surgery, University Federico II Naples, 80131 Naples, ItalyHematology and Hematopoietic Stem Cell Transplant Center, Department of Medicine and Surgery, University of Salerno, 84131 Salerno, ItalyEarly and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT). This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of auto- and allo-HSCT and outlines current options for their management. Gonadal impairment has been found early in approximately two-thirds of auto- and allo-HSCT patients: 90–99% of women and 60–90% of men. Dysfunctions of the hypothalamus-pituitary-growth hormone/insulin growth factor-I axis, hypothalamus-pituitary-thyroid axis, and hypothalamus-pituitary-adrenal axis were documented as later complicances, occurring in about 10, 30, and 40–50% of transplanted patients, respectively. Moreover, overt or subclinical thyroid complications (including persistent low-T3 syndrome, chronic thyroiditis, subclinical hypo- or hyperthyroidism, and thyroid carcinoma), gonadal failure, and adrenal insufficiency may persist many years after HSCT. Our analysis further provides evidence that main recognized risk factors for endocrine complications after HSCT are the underlying disease, previous pretransplant therapies, the age at HSCT, gender, total body irradiation, posttransplant derangement of immune system, and in the allogeneic setting, the presence of graft-versus-host disease requiring prolonged steroid treatment. Early identification of endocrine complications can greatly improve the quality of life of long-term survivors after HSCT.http://dx.doi.org/10.1155/2014/282147 |
| spellingShingle | Francesco Orio Giovanna Muscogiuri Stefano Palomba Bianca Serio Mariarosaria Sessa Valentina Giudice Idalucia Ferrara Libuse Tauchmanovà Annamaria Colao Carmine Selleri Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells The Scientific World Journal |
| title | Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells |
| title_full | Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells |
| title_fullStr | Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells |
| title_full_unstemmed | Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells |
| title_short | Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells |
| title_sort | endocrinopathies after allogeneic and autologous transplantation of hematopoietic stem cells |
| url | http://dx.doi.org/10.1155/2014/282147 |
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