Using protein turnover assay to explore the drug mechanism of Carfilzomib

Carfilzomib (CFZ) is the second-generation proteasome inhibitor that is approved by Food and Drug Administration (FDA) of USA for the treatment of relapsed and refractory multiple myeloma. Although the preclinical and clinical efficacy of CFZ is obvious, the mechanism by which CFZ leads to cell deat...

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Bibliographic Details
Main Authors: Tao Yonghui, Ding Xinyu, Jia Caiwei, Wang Chengcheng, Li Chuanyin
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-07-01
Series:Acta Biochimica et Biophysica Sinica
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Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024104
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