The bacterial composition signatures of perianal abscess and origin of infecting microbes
Background Perianal abscess is a common anal condition primarily caused by bacterial infections, yet the precise origins of these infecting bacteria remain unclear. Understanding the distinct microbial signatures associated with periaabscesses is crucial for provide fresh ideas for disease preventio...
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PeerJ Inc.
2025-01-01
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| author | Song Han Wenya Su Kefeng Fan Zhen Xu Hai Xu Mingyu Wang Ling Li Wenlong Shen |
| author_facet | Song Han Wenya Su Kefeng Fan Zhen Xu Hai Xu Mingyu Wang Ling Li Wenlong Shen |
| author_sort | Song Han |
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| description | Background Perianal abscess is a common anal condition primarily caused by bacterial infections, yet the precise origins of these infecting bacteria remain unclear. Understanding the distinct microbial signatures associated with periaabscesses is crucial for provide fresh ideas for disease prevention. Materials and Methods Samples of anal skin, feces, and abscesses were collected from a cohort of 75 patients diagnosed with perianal abscesses. The microbial composition at each site was analyzed using 16S rRNA gene sequencing to characterize the bacterial communities present. Results Analysis using MaAslin2 revealed distinct bacterial compositional signatures among the anal skin, feces, and abscess samples. Alpha diversity analysis indicated significant differences in bacterial diversity between abscesses, anal skin, and feces, with abscesses showing lower diversity compared to higher richness in feces. Biomarker analysis highlighted key taxa such as Bacteroides and Escherichia-Shisgella in fecal samples, and Staphylococcus and Corynebacterium in anal skin samples. The analysis of abscess samples suggested that the bacterial composition may originate from the skin, feces, and potentially other sources. |
| format | Article |
| id | doaj-art-327bf0efc1bf449caa8455d69ab1a097 |
| institution | Kabale University |
| issn | 2167-8359 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj-art-327bf0efc1bf449caa8455d69ab1a0972025-01-25T15:05:07ZengPeerJ Inc.PeerJ2167-83592025-01-0113e1885510.7717/peerj.18855The bacterial composition signatures of perianal abscess and origin of infecting microbesSong Han0Wenya Su1Kefeng Fan2Zhen Xu3Hai Xu4Mingyu Wang5Ling Li6Wenlong Shen7Department of Anorectal Surgery, Cheeloo College of Medicine, Qilu Hospital (Qingdao), Qingdao, ChinaState Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University (Qingdao), Qingdao, Shandong, ChinaDepartment of Respiratory Diseases, Qingdao Chengyang District People’s Hospital, Qingdao, ChinaDepartment of Anorectal Surgery, Cheeloo College of Medicine, Qilu Hospital (Qingdao), Qingdao, ChinaState Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University (Qingdao), Qingdao, Shandong, ChinaState Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University (Qingdao), Qingdao, Shandong, ChinaState Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University (Qingdao), Qingdao, Shandong, ChinaDepartment of Anorectal Surgery, Cheeloo College of Medicine, Qilu Hospital (Qingdao), Qingdao, ChinaBackground Perianal abscess is a common anal condition primarily caused by bacterial infections, yet the precise origins of these infecting bacteria remain unclear. Understanding the distinct microbial signatures associated with periaabscesses is crucial for provide fresh ideas for disease prevention. Materials and Methods Samples of anal skin, feces, and abscesses were collected from a cohort of 75 patients diagnosed with perianal abscesses. The microbial composition at each site was analyzed using 16S rRNA gene sequencing to characterize the bacterial communities present. Results Analysis using MaAslin2 revealed distinct bacterial compositional signatures among the anal skin, feces, and abscess samples. Alpha diversity analysis indicated significant differences in bacterial diversity between abscesses, anal skin, and feces, with abscesses showing lower diversity compared to higher richness in feces. Biomarker analysis highlighted key taxa such as Bacteroides and Escherichia-Shisgella in fecal samples, and Staphylococcus and Corynebacterium in anal skin samples. The analysis of abscess samples suggested that the bacterial composition may originate from the skin, feces, and potentially other sources.https://peerj.com/articles/18855.pdfPerianal abscessMicrobial composition16S rRNA gene sequencingSource of microbes |
| spellingShingle | Song Han Wenya Su Kefeng Fan Zhen Xu Hai Xu Mingyu Wang Ling Li Wenlong Shen The bacterial composition signatures of perianal abscess and origin of infecting microbes PeerJ Perianal abscess Microbial composition 16S rRNA gene sequencing Source of microbes |
| title | The bacterial composition signatures of perianal abscess and origin of infecting microbes |
| title_full | The bacterial composition signatures of perianal abscess and origin of infecting microbes |
| title_fullStr | The bacterial composition signatures of perianal abscess and origin of infecting microbes |
| title_full_unstemmed | The bacterial composition signatures of perianal abscess and origin of infecting microbes |
| title_short | The bacterial composition signatures of perianal abscess and origin of infecting microbes |
| title_sort | bacterial composition signatures of perianal abscess and origin of infecting microbes |
| topic | Perianal abscess Microbial composition 16S rRNA gene sequencing Source of microbes |
| url | https://peerj.com/articles/18855.pdf |
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