A multiscale model of the bone marrow and hematopoiesis
The bone marrow is necessary for renewal of all hematopoietic cells and critical for maintenance of a wide range of physiologic functions. Multiple human diseases result from bone marrow dysfunction. It is also the site in which liquid tumors, including leukemia and multiple myeloma, develop as wel...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2011-03-01
|
| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.643 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590177275478016 |
|---|---|
| author | Ariosto Silva Alexander R. A. Anderson Robert Gatenby |
| author_facet | Ariosto Silva Alexander R. A. Anderson Robert Gatenby |
| author_sort | Ariosto Silva |
| collection | DOAJ |
| description | The bone marrow is necessary for renewal of all hematopoietic cells and critical for maintenance of a wide range of physiologic functions. Multiple human diseases result from bone marrow dysfunction. It is also the site in which liquid tumors, including leukemia and multiple myeloma, develop as well as a frequent site of metastases. Understanding the complex cellular and microenvironmental interactions that govern normal bone marrow function as well as diseases and cancers of the bone marrow would be a valuable medical advance. Our goal is the development of a spatially-explicit in silico model of the bone marrow to understand both its normal function and the evolutionary dynamics that govern the emergence of bone marrow malignancy.Here we introduce a multiscale computational model of the bone marrow that incorporates three distinct spatial scales, cell, hematopoietic subunit, whole marrow.Our results, using parameter estimates from literature, recapitulates normal bone marrow function and suggest an explanation for the fractal-like structure of trabeculae and sinuses in the marrow, which would be an optimization of the hematopoietic function in order to maximize the number of mature blood cells produced daily within the volumetric restrictions of the marrow. |
| format | Article |
| id | doaj-art-32759663c3fc4fdf922da370f2c04cd3 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2011-03-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-32759663c3fc4fdf922da370f2c04cd32025-01-24T02:01:39ZengAIMS PressMathematical Biosciences and Engineering1551-00182011-03-018264365810.3934/mbe.2011.8.643A multiscale model of the bone marrow and hematopoiesisAriosto Silva0Alexander R. A. Anderson1Robert Gatenby2H Lee Moffitt Cancer Center, 12902 Magnolia Dr, Tampa, FL 33612H Lee Moffitt Cancer Center, 12902 Magnolia Dr, Tampa, FL 33612H Lee Moffitt Cancer Center, 12902 Magnolia Dr, Tampa, FL 33612The bone marrow is necessary for renewal of all hematopoietic cells and critical for maintenance of a wide range of physiologic functions. Multiple human diseases result from bone marrow dysfunction. It is also the site in which liquid tumors, including leukemia and multiple myeloma, develop as well as a frequent site of metastases. Understanding the complex cellular and microenvironmental interactions that govern normal bone marrow function as well as diseases and cancers of the bone marrow would be a valuable medical advance. Our goal is the development of a spatially-explicit in silico model of the bone marrow to understand both its normal function and the evolutionary dynamics that govern the emergence of bone marrow malignancy.Here we introduce a multiscale computational model of the bone marrow that incorporates three distinct spatial scales, cell, hematopoietic subunit, whole marrow.Our results, using parameter estimates from literature, recapitulates normal bone marrow function and suggest an explanation for the fractal-like structure of trabeculae and sinuses in the marrow, which would be an optimization of the hematopoietic function in order to maximize the number of mature blood cells produced daily within the volumetric restrictions of the marrow.https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.643hematopoiesismultiple myeloma.bone marrow |
| spellingShingle | Ariosto Silva Alexander R. A. Anderson Robert Gatenby A multiscale model of the bone marrow and hematopoiesis Mathematical Biosciences and Engineering hematopoiesis multiple myeloma. bone marrow |
| title | A multiscale model of the bone marrow and hematopoiesis |
| title_full | A multiscale model of the bone marrow and hematopoiesis |
| title_fullStr | A multiscale model of the bone marrow and hematopoiesis |
| title_full_unstemmed | A multiscale model of the bone marrow and hematopoiesis |
| title_short | A multiscale model of the bone marrow and hematopoiesis |
| title_sort | multiscale model of the bone marrow and hematopoiesis |
| topic | hematopoiesis multiple myeloma. bone marrow |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2011.8.643 |
| work_keys_str_mv | AT ariostosilva amultiscalemodelofthebonemarrowandhematopoiesis AT alexanderraanderson amultiscalemodelofthebonemarrowandhematopoiesis AT robertgatenby amultiscalemodelofthebonemarrowandhematopoiesis AT ariostosilva multiscalemodelofthebonemarrowandhematopoiesis AT alexanderraanderson multiscalemodelofthebonemarrowandhematopoiesis AT robertgatenby multiscalemodelofthebonemarrowandhematopoiesis |