Tuberculous Spondylitis following Intravesical Bacillus Calmette-Guerin for Bladder Cancer
We present a rare case of tuberculous spondylitis following intravesical Bacillus Calmette-Guerin (BCG) therapy for bladder cancer. An 82-year-old man presented with low back pain. Past medical history revealed bladder cancer diagnosed and treated 16 months previously by intravesical BCG. Magnetic r...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Orthopedics |
| Online Access: | http://dx.doi.org/10.1155/2016/6741284 |
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| author | Masashi Miyazaki Toyomi Yoshiiwa Toshinobu Ishihara Masanori Kawano Hiroshi Tsumura |
| author_facet | Masashi Miyazaki Toyomi Yoshiiwa Toshinobu Ishihara Masanori Kawano Hiroshi Tsumura |
| author_sort | Masashi Miyazaki |
| collection | DOAJ |
| description | We present a rare case of tuberculous spondylitis following intravesical Bacillus Calmette-Guerin (BCG) therapy for bladder cancer. An 82-year-old man presented with low back pain. Past medical history revealed bladder cancer diagnosed and treated 16 months previously by intravesical BCG. Magnetic resonance imaging of the thoracic spine showed destruction of the T5 and T6 vertebrae and an epidural soft tissue mass with anterior dural sac compression. Due to the progression of vertebral destruction, posterior spinal segmental fusion was performed. Mycobacterium bovis (M. bovis) was identified using multiplex polymerase chain reaction of surgical tissue specimens. The patient was started on an antituberculosis treatment regimen including isoniazid, rifampicin, and ethambutol. After surgery, his back pain resolved completely. At the latest examination, the patient was pain-free with no functional limitations or recurrent infection in clinical or imaging findings. Patients undergoing BCG therapy should be monitored for possible hematogenous spread of mycobacteria to the spine for months or even years after treatment. |
| format | Article |
| id | doaj-art-32682fd325b542caaf5f4aa783604aaa |
| institution | Kabale University |
| issn | 2090-6749 2090-6757 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Orthopedics |
| spelling | doaj-art-32682fd325b542caaf5f4aa783604aaa2025-02-03T07:24:44ZengWileyCase Reports in Orthopedics2090-67492090-67572016-01-01201610.1155/2016/67412846741284Tuberculous Spondylitis following Intravesical Bacillus Calmette-Guerin for Bladder CancerMasashi Miyazaki0Toyomi Yoshiiwa1Toshinobu Ishihara2Masanori Kawano3Hiroshi Tsumura4Department of Orthopaedic Surgery, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593, JapanDepartment of Orthopaedic Surgery, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593, JapanDepartment of Orthopaedic Surgery, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593, JapanDepartment of Orthopaedic Surgery, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593, JapanDepartment of Orthopaedic Surgery, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu-shi, Oita 879-5593, JapanWe present a rare case of tuberculous spondylitis following intravesical Bacillus Calmette-Guerin (BCG) therapy for bladder cancer. An 82-year-old man presented with low back pain. Past medical history revealed bladder cancer diagnosed and treated 16 months previously by intravesical BCG. Magnetic resonance imaging of the thoracic spine showed destruction of the T5 and T6 vertebrae and an epidural soft tissue mass with anterior dural sac compression. Due to the progression of vertebral destruction, posterior spinal segmental fusion was performed. Mycobacterium bovis (M. bovis) was identified using multiplex polymerase chain reaction of surgical tissue specimens. The patient was started on an antituberculosis treatment regimen including isoniazid, rifampicin, and ethambutol. After surgery, his back pain resolved completely. At the latest examination, the patient was pain-free with no functional limitations or recurrent infection in clinical or imaging findings. Patients undergoing BCG therapy should be monitored for possible hematogenous spread of mycobacteria to the spine for months or even years after treatment.http://dx.doi.org/10.1155/2016/6741284 |
| spellingShingle | Masashi Miyazaki Toyomi Yoshiiwa Toshinobu Ishihara Masanori Kawano Hiroshi Tsumura Tuberculous Spondylitis following Intravesical Bacillus Calmette-Guerin for Bladder Cancer Case Reports in Orthopedics |
| title | Tuberculous Spondylitis following Intravesical Bacillus Calmette-Guerin for Bladder Cancer |
| title_full | Tuberculous Spondylitis following Intravesical Bacillus Calmette-Guerin for Bladder Cancer |
| title_fullStr | Tuberculous Spondylitis following Intravesical Bacillus Calmette-Guerin for Bladder Cancer |
| title_full_unstemmed | Tuberculous Spondylitis following Intravesical Bacillus Calmette-Guerin for Bladder Cancer |
| title_short | Tuberculous Spondylitis following Intravesical Bacillus Calmette-Guerin for Bladder Cancer |
| title_sort | tuberculous spondylitis following intravesical bacillus calmette guerin for bladder cancer |
| url | http://dx.doi.org/10.1155/2016/6741284 |
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