The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis
Candida albicans is an opportunistic fungal pathogen that normally exists as a harmless commensal in humans. In instances where host debilitation occurs, Candida can cause a range of clinical infections, and whilst these are primarily superficial, effecting mucosal membranes, systemic infections ca...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/697340 |
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| author | Xiao-Qing Wei Helen Rogers Michael A. O. Lewis David W. Williams |
| author_facet | Xiao-Qing Wei Helen Rogers Michael A. O. Lewis David W. Williams |
| author_sort | Xiao-Qing Wei |
| collection | DOAJ |
| description | Candida albicans is an opportunistic fungal pathogen that normally exists as a harmless commensal in humans. In instances where host debilitation occurs, Candida can cause a range of clinical infections, and whilst these are primarily superficial, effecting mucosal membranes, systemic infections can develop in severely immunocompromised individuals. The mechanism of host immunity during commensal carriage of C. albicans has been intensively studied. In this paper, we present the most recent information concerning host recognition of C. albicans leading to cytokine production and the subsequent T-cell responses generated in response to C. albicans. Particular focus is given to the role of the IL-12 cytokine family including IL-12, IL-23, IL-27, and IL-35, in host immunity to Candida. CD4+ T-cells are considered crucial in the regulation of immunity and inflammation. In this regard, the role of Th1/2, helper cells, together with the recently identified Th17 and Treg cells in candidosis will be discussed. Understanding the detailed mechanisms that underlie host immunity to Candida not only will be of benefit in terms of the infections caused by this organism but could also be exploited in the development of therapeutic interventions for other diseases. |
| format | Article |
| id | doaj-art-326324a03c56461dbee182c3adc10e6a |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-326324a03c56461dbee182c3adc10e6a2025-02-03T01:32:38ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/697340697340The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral CandidosisXiao-Qing Wei0Helen Rogers1Michael A. O. Lewis2David W. Williams3Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, Heath Park, Cardiff CF14 4XY, UKTissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, Heath Park, Cardiff CF14 4XY, UKTissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, Heath Park, Cardiff CF14 4XY, UKTissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, Heath Park, Cardiff CF14 4XY, UKCandida albicans is an opportunistic fungal pathogen that normally exists as a harmless commensal in humans. In instances where host debilitation occurs, Candida can cause a range of clinical infections, and whilst these are primarily superficial, effecting mucosal membranes, systemic infections can develop in severely immunocompromised individuals. The mechanism of host immunity during commensal carriage of C. albicans has been intensively studied. In this paper, we present the most recent information concerning host recognition of C. albicans leading to cytokine production and the subsequent T-cell responses generated in response to C. albicans. Particular focus is given to the role of the IL-12 cytokine family including IL-12, IL-23, IL-27, and IL-35, in host immunity to Candida. CD4+ T-cells are considered crucial in the regulation of immunity and inflammation. In this regard, the role of Th1/2, helper cells, together with the recently identified Th17 and Treg cells in candidosis will be discussed. Understanding the detailed mechanisms that underlie host immunity to Candida not only will be of benefit in terms of the infections caused by this organism but could also be exploited in the development of therapeutic interventions for other diseases.http://dx.doi.org/10.1155/2011/697340 |
| spellingShingle | Xiao-Qing Wei Helen Rogers Michael A. O. Lewis David W. Williams The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis Clinical and Developmental Immunology |
| title | The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis |
| title_full | The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis |
| title_fullStr | The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis |
| title_full_unstemmed | The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis |
| title_short | The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral Candidosis |
| title_sort | role of the il 12 cytokine family in directing t cell responses in oral candidosis |
| url | http://dx.doi.org/10.1155/2011/697340 |
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