Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells
Breast cancer is one of the most common causes of deaths worldwide. Major obstacles to treatment have contributed to the increasing popularity of complementary or alternative therapies. Although recent results support the mechanism that honey induces cell death, the full mechanisms are still unknown...
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| Format: | Article |
| Language: | English |
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Çanakkale Onsekiz Mart University
2024-09-01
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| Series: | Journal of Advanced Research in Natural and Applied Sciences |
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| Online Access: | https://dergipark.org.tr/en/download/article-file/3811442 |
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| author | Ramazan Üzen Hamiyet Altuntaş Mustafa Çakır Pınar Altın Çelik Muazzez Derya Andeden |
| author_facet | Ramazan Üzen Hamiyet Altuntaş Mustafa Çakır Pınar Altın Çelik Muazzez Derya Andeden |
| author_sort | Ramazan Üzen |
| collection | DOAJ |
| description | Breast cancer is one of the most common causes of deaths worldwide. Major obstacles to treatment have contributed to the increasing popularity of complementary or alternative therapies. Although recent results support the mechanism that honey induces cell death, the full mechanisms are still unknown. This study investigates the potential use of Pervari honey (PH) as an in vitro therapeutic agent in breast cancer. Firstly, the antioxidant capacity and total phenolic content of PH were tested. In addition, MCF-7 and MDA-MB-231 breast cancer cells treated with PH were examined for cell viability, reactive oxygen species production, oxidative deoxyribonucleic acid (DNA) damage, and apoptosis. Our results show that PH treatment decreased cell viability dose-dependently and increased reactive oxygen species (ROS) levels, oxidative DNA damage, and apoptosis rate. The present study suggests that honey is a promising source to produce pharmaceuticals and nutraceuticals for breast cancer therapy. |
| format | Article |
| id | doaj-art-325f76ed2f0e43019a1abfbb357b0f62 |
| institution | Kabale University |
| issn | 2757-5195 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Çanakkale Onsekiz Mart University |
| record_format | Article |
| series | Journal of Advanced Research in Natural and Applied Sciences |
| spelling | doaj-art-325f76ed2f0e43019a1abfbb357b0f622025-02-05T18:13:03ZengÇanakkale Onsekiz Mart UniversityJournal of Advanced Research in Natural and Applied Sciences2757-51952024-09-0110362763910.28979/jarnas.1456528453Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer CellsRamazan Üzen0https://orcid.org/0000-0002-2208-1361Hamiyet Altuntaş1https://orcid.org/0000-0001-6473-5813Mustafa Çakır2https://orcid.org/0000-0002-8861-5485Pınar Altın Çelik3https://orcid.org/0000-0001-8429-009XMuazzez Derya Andeden4https://orcid.org/0000-0003-4390-5769ERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİVAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, TIP FAKÜLTESİERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİBreast cancer is one of the most common causes of deaths worldwide. Major obstacles to treatment have contributed to the increasing popularity of complementary or alternative therapies. Although recent results support the mechanism that honey induces cell death, the full mechanisms are still unknown. This study investigates the potential use of Pervari honey (PH) as an in vitro therapeutic agent in breast cancer. Firstly, the antioxidant capacity and total phenolic content of PH were tested. In addition, MCF-7 and MDA-MB-231 breast cancer cells treated with PH were examined for cell viability, reactive oxygen species production, oxidative deoxyribonucleic acid (DNA) damage, and apoptosis. Our results show that PH treatment decreased cell viability dose-dependently and increased reactive oxygen species (ROS) levels, oxidative DNA damage, and apoptosis rate. The present study suggests that honey is a promising source to produce pharmaceuticals and nutraceuticals for breast cancer therapy.https://dergipark.org.tr/en/download/article-file/3811442antioxidantapoptosiscancerhoneyoxidative deoxyribonucleic acid (dna) damagereactive oxygen species |
| spellingShingle | Ramazan Üzen Hamiyet Altuntaş Mustafa Çakır Pınar Altın Çelik Muazzez Derya Andeden Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells Journal of Advanced Research in Natural and Applied Sciences antioxidant apoptosis cancer honey oxidative deoxyribonucleic acid (dna) damage reactive oxygen species |
| title | Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells |
| title_full | Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells |
| title_fullStr | Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells |
| title_full_unstemmed | Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells |
| title_short | Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells |
| title_sort | effects of pervari honey from turkiye on proliferation oxidative stress and apoptosis of human breast cancer cells |
| topic | antioxidant apoptosis cancer honey oxidative deoxyribonucleic acid (dna) damage reactive oxygen species |
| url | https://dergipark.org.tr/en/download/article-file/3811442 |
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