Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach
<i>Background and Objectives</i>: Periodontal inflammation, often linked to oral microbiota dysbiosis dominated by pathogenic bacteria, remains a significant challenge in periodontitis management. Traditional periodontal therapies primarily reduce the bacterial load but fail to restore t...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/61/1/126 |
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| author | Liliana Sachelarie Ioana Scrobota Ioana Romanul Raluca Iurcov Georgiana Ioana Potra Cicalau Liana Todor |
| author_facet | Liliana Sachelarie Ioana Scrobota Ioana Romanul Raluca Iurcov Georgiana Ioana Potra Cicalau Liana Todor |
| author_sort | Liliana Sachelarie |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Periodontal inflammation, often linked to oral microbiota dysbiosis dominated by pathogenic bacteria, remains a significant challenge in periodontitis management. Traditional periodontal therapies primarily reduce the bacterial load but fail to restore the microbiota balance. Probiotics offer a promising therapeutic adjunct with their ability to enhance beneficial bacteria. This study investigates the effects of probiotics on the oral microbiota, inflammatory markers (IL-1β, TNF-α), and clinical parameters (gingival index, bleeding index, and periodontal pocket depth). <i>Materials and Methods</i>: In this pilot study, 80 patients with moderate-to-severe periodontitis were assigned to two groups. Group A received standard periodontal therapy (non-surgical periodontal therapy (NSPT)) with probiotic supplementation (<i>Lactobacillus reuteri</i>, 2 × 10⁹ CFU daily for 8 weeks), and Group B received standard treatment with a placebo. Microbiological changes were assessed via quantitative PCR, while inflammatory markers (IL-1β, TNF-α) were analyzed using ELISA. Clinical parameters, including the gingival index (GI), bleeding index (BI), and periodontal pocket depth (PPD), were measured at baseline (T0), 4 weeks (T1), and 8 weeks (T2) using standardized methods. <i>Results</i>: Probiotic therapy (Group A) significantly reduced the pathogenic bacteria and increased the beneficial bacteria levels compared to the placebo (<i>p</i> < 0.01). Inflammatory markers decreased by 37% (IL-1β) and 42% (TNF-α), while clinical parameters improved, with reductions in the gingival and bleeding indices (−1.5, −1.3) and a 2 mm decrease in the periodontal pocket depth (<i>p</i> < 0.01). <i>Conclusions</i>: Probiotics, as an adjunct to periodontal therapy, effectively restore the microbiota balance, reduce inflammation, and improve clinical outcomes in periodontitis. |
| format | Article |
| id | doaj-art-325429e4b2db44ada2f7ad767bb256b1 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-325429e4b2db44ada2f7ad767bb256b12025-01-24T13:40:44ZengMDPI AGMedicina1010-660X1648-91442025-01-0161112610.3390/medicina61010126Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative ApproachLiliana Sachelarie0Ioana Scrobota1Ioana Romanul2Raluca Iurcov3Georgiana Ioana Potra Cicalau4Liana Todor5Department of Preclinical Discipline, Faculty of Medicine, Apollonia University, 700511 Iasi, RomaniaDepartment of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 10 1st Decembrie Street, 410073 Oradea, RomaniaDepartment of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 10 1st Decembrie Street, 410073 Oradea, RomaniaDepartment of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 10 1st Decembrie Street, 410073 Oradea, RomaniaDepartment of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 10 1st Decembrie Street, 410073 Oradea, RomaniaDepartment of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 10 1st Decembrie Street, 410073 Oradea, Romania<i>Background and Objectives</i>: Periodontal inflammation, often linked to oral microbiota dysbiosis dominated by pathogenic bacteria, remains a significant challenge in periodontitis management. Traditional periodontal therapies primarily reduce the bacterial load but fail to restore the microbiota balance. Probiotics offer a promising therapeutic adjunct with their ability to enhance beneficial bacteria. This study investigates the effects of probiotics on the oral microbiota, inflammatory markers (IL-1β, TNF-α), and clinical parameters (gingival index, bleeding index, and periodontal pocket depth). <i>Materials and Methods</i>: In this pilot study, 80 patients with moderate-to-severe periodontitis were assigned to two groups. Group A received standard periodontal therapy (non-surgical periodontal therapy (NSPT)) with probiotic supplementation (<i>Lactobacillus reuteri</i>, 2 × 10⁹ CFU daily for 8 weeks), and Group B received standard treatment with a placebo. Microbiological changes were assessed via quantitative PCR, while inflammatory markers (IL-1β, TNF-α) were analyzed using ELISA. Clinical parameters, including the gingival index (GI), bleeding index (BI), and periodontal pocket depth (PPD), were measured at baseline (T0), 4 weeks (T1), and 8 weeks (T2) using standardized methods. <i>Results</i>: Probiotic therapy (Group A) significantly reduced the pathogenic bacteria and increased the beneficial bacteria levels compared to the placebo (<i>p</i> < 0.01). Inflammatory markers decreased by 37% (IL-1β) and 42% (TNF-α), while clinical parameters improved, with reductions in the gingival and bleeding indices (−1.5, −1.3) and a 2 mm decrease in the periodontal pocket depth (<i>p</i> < 0.01). <i>Conclusions</i>: Probiotics, as an adjunct to periodontal therapy, effectively restore the microbiota balance, reduce inflammation, and improve clinical outcomes in periodontitis.https://www.mdpi.com/1648-9144/61/1/126probioticsperiodontal therapyoral microbiota |
| spellingShingle | Liliana Sachelarie Ioana Scrobota Ioana Romanul Raluca Iurcov Georgiana Ioana Potra Cicalau Liana Todor Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach Medicina probiotics periodontal therapy oral microbiota |
| title | Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach |
| title_full | Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach |
| title_fullStr | Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach |
| title_full_unstemmed | Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach |
| title_short | Probiotic Therapy as an Adjuvant in the Treatment of Periodontal Disease: An Innovative Approach |
| title_sort | probiotic therapy as an adjuvant in the treatment of periodontal disease an innovative approach |
| topic | probiotics periodontal therapy oral microbiota |
| url | https://www.mdpi.com/1648-9144/61/1/126 |
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