Maximizing the Survival of Amyotrophic Lateral Sclerosis Patients: Current Perspectives
Amyotrophic lateral sclerosis is a neurodegenerative disease that leads to loss of the upper and lower motor neurons. Almost 90% of all cases occur in the sporadic form, with the rest occurring in the familial form. The disease has a poor prognosis, with only two disease-modifying drugs approved by...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2018/6534150 |
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| author | Osama A. Khairoalsindi Ahmad R. Abuzinadah |
| author_facet | Osama A. Khairoalsindi Ahmad R. Abuzinadah |
| author_sort | Osama A. Khairoalsindi |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis is a neurodegenerative disease that leads to loss of the upper and lower motor neurons. Almost 90% of all cases occur in the sporadic form, with the rest occurring in the familial form. The disease has a poor prognosis, with only two disease-modifying drugs approved by the United States Food and Drug Administration (FDA). The approved drugs for the disease have very limited survival benefits. Edaravone is a new FDA-approved medication that may slow the disease progression by 33% in a selected subgroup of ALS patients. This paper covers the various interventions that may provide survival benefits, such as early diagnosis, medications, gene therapy, stem cell therapy, diet, nutritional supplements, multidisciplinary clinics, and mechanical invasive and noninvasive ventilation. The recent data on masitinib, the role of enteral feeding, gene therapy, and stem cell therapy is discussed. |
| format | Article |
| id | doaj-art-324cb31996df4a9391b15d365e4c704d |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-324cb31996df4a9391b15d365e4c704d2025-02-03T05:48:39ZengWileyNeurology Research International2090-18522090-18602018-01-01201810.1155/2018/65341506534150Maximizing the Survival of Amyotrophic Lateral Sclerosis Patients: Current PerspectivesOsama A. Khairoalsindi0Ahmad R. Abuzinadah1Umm Al-Qura University, College of Medicine, Makkah, Saudi ArabiaKing Abdulaziz University, Internal Medicine Department, Neurology Division, Jeddah, Saudi ArabiaAmyotrophic lateral sclerosis is a neurodegenerative disease that leads to loss of the upper and lower motor neurons. Almost 90% of all cases occur in the sporadic form, with the rest occurring in the familial form. The disease has a poor prognosis, with only two disease-modifying drugs approved by the United States Food and Drug Administration (FDA). The approved drugs for the disease have very limited survival benefits. Edaravone is a new FDA-approved medication that may slow the disease progression by 33% in a selected subgroup of ALS patients. This paper covers the various interventions that may provide survival benefits, such as early diagnosis, medications, gene therapy, stem cell therapy, diet, nutritional supplements, multidisciplinary clinics, and mechanical invasive and noninvasive ventilation. The recent data on masitinib, the role of enteral feeding, gene therapy, and stem cell therapy is discussed.http://dx.doi.org/10.1155/2018/6534150 |
| spellingShingle | Osama A. Khairoalsindi Ahmad R. Abuzinadah Maximizing the Survival of Amyotrophic Lateral Sclerosis Patients: Current Perspectives Neurology Research International |
| title | Maximizing the Survival of Amyotrophic Lateral Sclerosis Patients: Current Perspectives |
| title_full | Maximizing the Survival of Amyotrophic Lateral Sclerosis Patients: Current Perspectives |
| title_fullStr | Maximizing the Survival of Amyotrophic Lateral Sclerosis Patients: Current Perspectives |
| title_full_unstemmed | Maximizing the Survival of Amyotrophic Lateral Sclerosis Patients: Current Perspectives |
| title_short | Maximizing the Survival of Amyotrophic Lateral Sclerosis Patients: Current Perspectives |
| title_sort | maximizing the survival of amyotrophic lateral sclerosis patients current perspectives |
| url | http://dx.doi.org/10.1155/2018/6534150 |
| work_keys_str_mv | AT osamaakhairoalsindi maximizingthesurvivalofamyotrophiclateralsclerosispatientscurrentperspectives AT ahmadrabuzinadah maximizingthesurvivalofamyotrophiclateralsclerosispatientscurrentperspectives |