Clinical Characteristics and Outcomes of Patients Hospitalized with COVID-19 at Case Hospital, Uganda
Data on clinical outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19) in private health facilities in Uganda is scarce. We conducted a retrospective cohort study of patients hospitalized with COVID-19 at Case Hospital, Kampala, Uganda, between June 2020 and September 2021. Data...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2022/5477790 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565497150832640 |
|---|---|
| author | Mirriam Apiyo Ronald Olum Amina Kabuye Betty Khainza Anne M. Amate Vittal Byabashaija Derrick Nomujuni Kato Sebbaale Peter Senfuka Simon Kazibwe Gurav Sharma Lindsay Davidson Felix Bongomin |
| author_facet | Mirriam Apiyo Ronald Olum Amina Kabuye Betty Khainza Anne M. Amate Vittal Byabashaija Derrick Nomujuni Kato Sebbaale Peter Senfuka Simon Kazibwe Gurav Sharma Lindsay Davidson Felix Bongomin |
| author_sort | Mirriam Apiyo |
| collection | DOAJ |
| description | Data on clinical outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19) in private health facilities in Uganda is scarce. We conducted a retrospective cohort study of patients hospitalized with COVID-19 at Case Hospital, Kampala, Uganda, between June 2020 and September 2021. Data of 160 participants (median age 45 years (interquartile range [IQR]: 37–57) and 63.5% male) was analyzed. Seventy-seven (48.1%) participants had non-severe, 18 (11.3%) severe, and 83 (51.9%) critical COVID-19 illness. In 62 participants with chest computed tomography findings, 54 (87%) had bilateral disease, with 22 (35%) having ground-glass opacities. The median duration of hospitalization was 5 days (IQR: 3–9 days). Overall, 18 (11.3%) participants died. Survival at 14 and 28 days was 89% and 72%, respectively. Factors strongly associated with all-cause mortality were as follows: age >50 years (odds ratio [OR]: 8.6, 95% confidence interval [CI]: 1.1–69.2, and p=0.042), having at least 1 comorbidity (OR: 3.2, 95% CI: 1.1–8.9, and p=0.029), hypertension (OR: 3.2, 95% CI: 1.2–8.6, and p=0.024), diabetes mellitus (OR: 2.9, 95% CI: 1.0–8.5, andp=0.056), and oxygen saturation <92% (OR: 5.1, 95% CI: 1.8–14.4, and p=0.002). In this private health facility, mortality was about 1 in 10 patients, and more people presented with critical illness in the second wave of the pandemic, and most deaths occurred after 2 weeks of hospitalization. |
| format | Article |
| id | doaj-art-32439e7b909147ddac259e425fd9597e |
| institution | Kabale University |
| issn | 1687-7098 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-32439e7b909147ddac259e425fd9597e2025-02-03T01:07:22ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-70982022-01-01202210.1155/2022/5477790Clinical Characteristics and Outcomes of Patients Hospitalized with COVID-19 at Case Hospital, UgandaMirriam Apiyo0Ronald Olum1Amina Kabuye2Betty Khainza3Anne M. Amate4Vittal Byabashaija5Derrick Nomujuni6Kato Sebbaale7Peter Senfuka8Simon Kazibwe9Gurav Sharma10Lindsay Davidson11Felix Bongomin12Case HospitalDepartment of Internal MedicineCase HospitalCase HospitalCase HospitalCase HospitalCase HospitalCase HospitalCase HospitalCase HospitalCase HospitalCase HospitalDepartment of Medical Microbiology & ImmunologyData on clinical outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19) in private health facilities in Uganda is scarce. We conducted a retrospective cohort study of patients hospitalized with COVID-19 at Case Hospital, Kampala, Uganda, between June 2020 and September 2021. Data of 160 participants (median age 45 years (interquartile range [IQR]: 37–57) and 63.5% male) was analyzed. Seventy-seven (48.1%) participants had non-severe, 18 (11.3%) severe, and 83 (51.9%) critical COVID-19 illness. In 62 participants with chest computed tomography findings, 54 (87%) had bilateral disease, with 22 (35%) having ground-glass opacities. The median duration of hospitalization was 5 days (IQR: 3–9 days). Overall, 18 (11.3%) participants died. Survival at 14 and 28 days was 89% and 72%, respectively. Factors strongly associated with all-cause mortality were as follows: age >50 years (odds ratio [OR]: 8.6, 95% confidence interval [CI]: 1.1–69.2, and p=0.042), having at least 1 comorbidity (OR: 3.2, 95% CI: 1.1–8.9, and p=0.029), hypertension (OR: 3.2, 95% CI: 1.2–8.6, and p=0.024), diabetes mellitus (OR: 2.9, 95% CI: 1.0–8.5, andp=0.056), and oxygen saturation <92% (OR: 5.1, 95% CI: 1.8–14.4, and p=0.002). In this private health facility, mortality was about 1 in 10 patients, and more people presented with critical illness in the second wave of the pandemic, and most deaths occurred after 2 weeks of hospitalization.http://dx.doi.org/10.1155/2022/5477790 |
| spellingShingle | Mirriam Apiyo Ronald Olum Amina Kabuye Betty Khainza Anne M. Amate Vittal Byabashaija Derrick Nomujuni Kato Sebbaale Peter Senfuka Simon Kazibwe Gurav Sharma Lindsay Davidson Felix Bongomin Clinical Characteristics and Outcomes of Patients Hospitalized with COVID-19 at Case Hospital, Uganda Interdisciplinary Perspectives on Infectious Diseases |
| title | Clinical Characteristics and Outcomes of Patients Hospitalized with COVID-19 at Case Hospital, Uganda |
| title_full | Clinical Characteristics and Outcomes of Patients Hospitalized with COVID-19 at Case Hospital, Uganda |
| title_fullStr | Clinical Characteristics and Outcomes of Patients Hospitalized with COVID-19 at Case Hospital, Uganda |
| title_full_unstemmed | Clinical Characteristics and Outcomes of Patients Hospitalized with COVID-19 at Case Hospital, Uganda |
| title_short | Clinical Characteristics and Outcomes of Patients Hospitalized with COVID-19 at Case Hospital, Uganda |
| title_sort | clinical characteristics and outcomes of patients hospitalized with covid 19 at case hospital uganda |
| url | http://dx.doi.org/10.1155/2022/5477790 |
| work_keys_str_mv | AT mirriamapiyo clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda AT ronaldolum clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda AT aminakabuye clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda AT bettykhainza clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda AT annemamate clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda AT vittalbyabashaija clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda AT derricknomujuni clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda AT katosebbaale clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda AT petersenfuka clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda AT simonkazibwe clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda AT guravsharma clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda AT lindsaydavidson clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda AT felixbongomin clinicalcharacteristicsandoutcomesofpatientshospitalizedwithcovid19atcasehospitaluganda |