APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs

APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs

Tumor suppressor protein Adenomatous polyposis coli protein (APC) is an EB-binding and microtubule (MT) plus end-tracking protein; however, how exactly APC regulates MT dynamics remains elusive. Here, we show that in LLC-PK1 cells, APC and KIF2A, an MT depolymerase, form a complex clustering at the...

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Bibliographic Details
Main Authors: Yong Wang, Xinping Liu, Zheng Liu, Shasha Hua, Kai Jiang
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Cell Insight
Subjects:
Microtubule
Adenomatous polyposis coli protein
APC
CLASPs
KIF2A
Online Access:http://www.sciencedirect.com/science/article/pii/S2772892724000658
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