Divergent Effects of <i>Circoviridae</i> Capsid Proteins on Type I Interferon Signaling
Viruses in the <i>Circoviridae</i> family can infect mammals and birds. Porcine circovirus type 2 (PCV2) significantly affects the livestock industry by causing porcine circovirus-associated diseases, such as postweaning multisystem wasting syndrome, respiratory disease complex, and derm...
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2025-01-01
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| author | Anon H. Kosaka Chen-Yu Huang Zih-Ying Lu Hua-Zhen Hsing Amonrat Choonnasard Rissar Siringo Ringo Kuo Pin Chuang Akatsuki Saito |
| author_facet | Anon H. Kosaka Chen-Yu Huang Zih-Ying Lu Hua-Zhen Hsing Amonrat Choonnasard Rissar Siringo Ringo Kuo Pin Chuang Akatsuki Saito |
| author_sort | Anon H. Kosaka |
| collection | DOAJ |
| description | Viruses in the <i>Circoviridae</i> family can infect mammals and birds. Porcine circovirus type 2 (PCV2) significantly affects the livestock industry by causing porcine circovirus-associated diseases, such as postweaning multisystem wasting syndrome, respiratory disease complex, and dermatitis nephropathy syndrome. Additionally, beak and feather disease virus in parrots, canine circovirus in dogs, and columbid circovirus (pigeon circovirus) in racing pigeons induce immunosuppression, followed by secondary infections in these hosts. Although the PCV2 capsid protein has been demonstrated to inhibit type I interferon (IFN) signaling, the molecular mechanisms of <i>Circoviridae</i>-induced immunosuppression are largely unknown. In this study, we examined whether these functions are conserved across <i>Circoviridae</i> capsid proteins. Our results illustrated that although the nuclear localization of capsid proteins is conserved, their effects on IFN-β signaling vary by species, revealing the diverse roles of <i>Circoviridae</i> capsid proteins in modulating immune responses. |
| format | Article |
| id | doaj-art-323076adac174708928f19bc1f8634fa |
| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-323076adac174708928f19bc1f8634fa2025-01-24T13:44:47ZengMDPI AGPathogens2076-08172025-01-011416810.3390/pathogens14010068Divergent Effects of <i>Circoviridae</i> Capsid Proteins on Type I Interferon SignalingAnon H. Kosaka0Chen-Yu Huang1Zih-Ying Lu2Hua-Zhen Hsing3Amonrat Choonnasard4Rissar Siringo Ringo5Kuo Pin Chuang6Akatsuki Saito7Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanGraduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912, TaiwanGraduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912, TaiwanGraduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912, TaiwanDepartment of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanDepartment of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanGraduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912, TaiwanDepartment of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, JapanViruses in the <i>Circoviridae</i> family can infect mammals and birds. Porcine circovirus type 2 (PCV2) significantly affects the livestock industry by causing porcine circovirus-associated diseases, such as postweaning multisystem wasting syndrome, respiratory disease complex, and dermatitis nephropathy syndrome. Additionally, beak and feather disease virus in parrots, canine circovirus in dogs, and columbid circovirus (pigeon circovirus) in racing pigeons induce immunosuppression, followed by secondary infections in these hosts. Although the PCV2 capsid protein has been demonstrated to inhibit type I interferon (IFN) signaling, the molecular mechanisms of <i>Circoviridae</i>-induced immunosuppression are largely unknown. In this study, we examined whether these functions are conserved across <i>Circoviridae</i> capsid proteins. Our results illustrated that although the nuclear localization of capsid proteins is conserved, their effects on IFN-β signaling vary by species, revealing the diverse roles of <i>Circoviridae</i> capsid proteins in modulating immune responses.https://www.mdpi.com/2076-0817/14/1/68<i>Circoviridae</i>capsid proteinsinterferon β signaling |
| spellingShingle | Anon H. Kosaka Chen-Yu Huang Zih-Ying Lu Hua-Zhen Hsing Amonrat Choonnasard Rissar Siringo Ringo Kuo Pin Chuang Akatsuki Saito Divergent Effects of <i>Circoviridae</i> Capsid Proteins on Type I Interferon Signaling Pathogens <i>Circoviridae</i> capsid proteins interferon β signaling |
| title | Divergent Effects of <i>Circoviridae</i> Capsid Proteins on Type I Interferon Signaling |
| title_full | Divergent Effects of <i>Circoviridae</i> Capsid Proteins on Type I Interferon Signaling |
| title_fullStr | Divergent Effects of <i>Circoviridae</i> Capsid Proteins on Type I Interferon Signaling |
| title_full_unstemmed | Divergent Effects of <i>Circoviridae</i> Capsid Proteins on Type I Interferon Signaling |
| title_short | Divergent Effects of <i>Circoviridae</i> Capsid Proteins on Type I Interferon Signaling |
| title_sort | divergent effects of i circoviridae i capsid proteins on type i interferon signaling |
| topic | <i>Circoviridae</i> capsid proteins interferon β signaling |
| url | https://www.mdpi.com/2076-0817/14/1/68 |
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