Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators?
The strict link between periodontitis (PD) and rheumatoid arthritis (RA) has been widely demonstrated by several studies. PD is significantly more frequent in RA patients in comparison with healthy subjects: this prevalence is higher in individuals at the earliest stages of disease and in seropositi...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/6034546 |
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| author | Fulvia Ceccarelli Matteo Saccucci Gabriele Di Carlo Ramona Lucchetti Andrea Pilloni Nicola Pranno Valeria Luzzi Guido Valesini Antonella Polimeni |
| author_facet | Fulvia Ceccarelli Matteo Saccucci Gabriele Di Carlo Ramona Lucchetti Andrea Pilloni Nicola Pranno Valeria Luzzi Guido Valesini Antonella Polimeni |
| author_sort | Fulvia Ceccarelli |
| collection | DOAJ |
| description | The strict link between periodontitis (PD) and rheumatoid arthritis (RA) has been widely demonstrated by several studies. PD is significantly more frequent in RA patients in comparison with healthy subjects: this prevalence is higher in individuals at the earliest stages of disease and in seropositive patients. This is probably related to the role of P. gingivalis in inducing citrullination and leading to the development of the new antigens. Despite the many studies conducted on this topic, there is very little data available concerning the possibility to use the same biomarkers to evaluate both RA and PD patients. The aim of the review is to summarize this issue. Starting from genetic factors, data from literature demonstrated the association between HLA-DRB1 alleles and PD susceptibility, similar to RA patients; moreover, SE-positive patients showed simultaneously structural damage to the wrist and periodontal sites. Contrasting results are available concerning other genetic polymorphisms. Moreover, the possible role of proinflammatory cytokines, such as TNF and IL6 and autoantibodies, specifically anticyclic citrullinated peptide antibodies, has been examined, suggesting the need to perform further studies to better define this issue. |
| format | Article |
| id | doaj-art-322cf317fb4147daa8984aced8a7efbc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-322cf317fb4147daa8984aced8a7efbc2025-02-03T01:06:55ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/60345466034546Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators?Fulvia Ceccarelli0Matteo Saccucci1Gabriele Di Carlo2Ramona Lucchetti3Andrea Pilloni4Nicola Pranno5Valeria Luzzi6Guido Valesini7Antonella Polimeni8Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, ItalyDepartment of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161 Rome, ItalyDepartment of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161 Rome, ItalyDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, ItalyDepartment of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161 Rome, ItalyDepartment of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161 Rome, ItalyDepartment of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161 Rome, ItalyDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, ItalyDepartment of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Viale Regina Elena 287a, 00161 Rome, ItalyThe strict link between periodontitis (PD) and rheumatoid arthritis (RA) has been widely demonstrated by several studies. PD is significantly more frequent in RA patients in comparison with healthy subjects: this prevalence is higher in individuals at the earliest stages of disease and in seropositive patients. This is probably related to the role of P. gingivalis in inducing citrullination and leading to the development of the new antigens. Despite the many studies conducted on this topic, there is very little data available concerning the possibility to use the same biomarkers to evaluate both RA and PD patients. The aim of the review is to summarize this issue. Starting from genetic factors, data from literature demonstrated the association between HLA-DRB1 alleles and PD susceptibility, similar to RA patients; moreover, SE-positive patients showed simultaneously structural damage to the wrist and periodontal sites. Contrasting results are available concerning other genetic polymorphisms. Moreover, the possible role of proinflammatory cytokines, such as TNF and IL6 and autoantibodies, specifically anticyclic citrullinated peptide antibodies, has been examined, suggesting the need to perform further studies to better define this issue.http://dx.doi.org/10.1155/2019/6034546 |
| spellingShingle | Fulvia Ceccarelli Matteo Saccucci Gabriele Di Carlo Ramona Lucchetti Andrea Pilloni Nicola Pranno Valeria Luzzi Guido Valesini Antonella Polimeni Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators? Mediators of Inflammation |
| title | Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators? |
| title_full | Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators? |
| title_fullStr | Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators? |
| title_full_unstemmed | Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators? |
| title_short | Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators? |
| title_sort | periodontitis and rheumatoid arthritis the same inflammatory mediators |
| url | http://dx.doi.org/10.1155/2019/6034546 |
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