Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value
Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most eukaryotic cells. Containing proteins, RNA, and DNA, exosomes mediate intercellular communication between different cell types by transferring their contents and thus are involved in numerous ph...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/8481013 |
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| _version_ | 1832560097479360512 |
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| author | Yuanyuan Shao Xiaofeng Pan Rong Fu |
| author_facet | Yuanyuan Shao Xiaofeng Pan Rong Fu |
| author_sort | Yuanyuan Shao |
| collection | DOAJ |
| description | Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most eukaryotic cells. Containing proteins, RNA, and DNA, exosomes mediate intercellular communication between different cell types by transferring their contents and thus are involved in numerous physiological and pathological processes. T cells are an indispensable part of adaptive immunity, and the functions of T cell-derived exosomes have been widely studied. In the more than three decades since the discovery of exosomes, several studies have revealed that T cell-derived exosomes play a novel role in cell-to-cell signaling, especially in inflammatory responses, autoimmunity, and infectious diseases. In this review, we will summarize the function of T cell-derived exosomes and their therapeutic potential. |
| format | Article |
| id | doaj-art-322b99029e23490291ae53b1d978e913 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-322b99029e23490291ae53b1d978e9132025-02-03T01:28:22ZengWileyMediators of Inflammation1466-18612021-01-01202110.1155/2021/8481013Role and Function of T Cell-Derived Exosomes and Their Therapeutic ValueYuanyuan Shao0Xiaofeng Pan1Rong Fu2Department of HematopathologyDepartment of HematopathologyDepartment of HematopathologyExosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most eukaryotic cells. Containing proteins, RNA, and DNA, exosomes mediate intercellular communication between different cell types by transferring their contents and thus are involved in numerous physiological and pathological processes. T cells are an indispensable part of adaptive immunity, and the functions of T cell-derived exosomes have been widely studied. In the more than three decades since the discovery of exosomes, several studies have revealed that T cell-derived exosomes play a novel role in cell-to-cell signaling, especially in inflammatory responses, autoimmunity, and infectious diseases. In this review, we will summarize the function of T cell-derived exosomes and their therapeutic potential.http://dx.doi.org/10.1155/2021/8481013 |
| spellingShingle | Yuanyuan Shao Xiaofeng Pan Rong Fu Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value Mediators of Inflammation |
| title | Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value |
| title_full | Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value |
| title_fullStr | Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value |
| title_full_unstemmed | Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value |
| title_short | Role and Function of T Cell-Derived Exosomes and Their Therapeutic Value |
| title_sort | role and function of t cell derived exosomes and their therapeutic value |
| url | http://dx.doi.org/10.1155/2021/8481013 |
| work_keys_str_mv | AT yuanyuanshao roleandfunctionoftcellderivedexosomesandtheirtherapeuticvalue AT xiaofengpan roleandfunctionoftcellderivedexosomesandtheirtherapeuticvalue AT rongfu roleandfunctionoftcellderivedexosomesandtheirtherapeuticvalue |