Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain
Studies have found that early traumatic experience significantly increases the risk of posttraumatic stress disorder (PTSD). Gamma-aminobutyric acid (GABA) deficits were proposed to be implicated in development of PTSD, but the alterations of GABA receptor A (GABAAR) subunits induced by early trauma...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/5715816 |
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| author | Cui Yan Lu De Xiang Liu Hong Jiang Fang Pan Cyrus S. H. Ho Roger C. M. Ho |
| author_facet | Cui Yan Lu De Xiang Liu Hong Jiang Fang Pan Cyrus S. H. Ho Roger C. M. Ho |
| author_sort | Cui Yan Lu |
| collection | DOAJ |
| description | Studies have found that early traumatic experience significantly increases the risk of posttraumatic stress disorder (PTSD). Gamma-aminobutyric acid (GABA) deficits were proposed to be implicated in development of PTSD, but the alterations of GABA receptor A (GABAAR) subunits induced by early traumatic stress have not been fully elucidated. Furthermore, previous studies suggested that exercise could be more effective than medications in reducing severity of anxiety and depression but the mechanism is unclear. This study used inescapable foot-shock to induce PTSD in juvenile rats and examined their emotional changes using open-field test and elevated plus maze, memory changes using Morris water maze, and the expression of GABAAR subunits (γ2, α2, and α5) in subregions of the brain in the adulthood using western blotting and immunohistochemistry. We aimed to observe the role of GABAAR subunits changes induced by juvenile trauma in the pathogenesis of subsequent PTSD in adulthood. In addition, we investigated the protective effects of exercise for 6 weeks and benzodiazepine (clonazepam) for 2 weeks. This study found that juvenile traumatic stress induced chronic anxiety and spatial memory loss and reduced expression of GABAAR subunits in the adult rat brains. Furthermore, exercise led to significant improvement as compared to short-term BZ treatment. |
| format | Article |
| id | doaj-art-322b5f0d254148d8b71dbf931a33de94 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-322b5f0d254148d8b71dbf931a33de942025-02-03T06:08:21ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/57158165715816Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat BrainCui Yan Lu0De Xiang Liu1Hong Jiang2Fang Pan3Cyrus S. H. Ho4Roger C. M. Ho5Department of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong 250012, ChinaDepartment of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong 250012, ChinaDepartment of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong 250012, ChinaDepartment of Medical Psychology, Shandong University School of Medicine, Jinan, Shandong 250012, ChinaDepartment of Psychological Medicine, National University of Singapore, 119228, SingaporeDepartment of Psychological Medicine, National University of Singapore, 119228, SingaporeStudies have found that early traumatic experience significantly increases the risk of posttraumatic stress disorder (PTSD). Gamma-aminobutyric acid (GABA) deficits were proposed to be implicated in development of PTSD, but the alterations of GABA receptor A (GABAAR) subunits induced by early traumatic stress have not been fully elucidated. Furthermore, previous studies suggested that exercise could be more effective than medications in reducing severity of anxiety and depression but the mechanism is unclear. This study used inescapable foot-shock to induce PTSD in juvenile rats and examined their emotional changes using open-field test and elevated plus maze, memory changes using Morris water maze, and the expression of GABAAR subunits (γ2, α2, and α5) in subregions of the brain in the adulthood using western blotting and immunohistochemistry. We aimed to observe the role of GABAAR subunits changes induced by juvenile trauma in the pathogenesis of subsequent PTSD in adulthood. In addition, we investigated the protective effects of exercise for 6 weeks and benzodiazepine (clonazepam) for 2 weeks. This study found that juvenile traumatic stress induced chronic anxiety and spatial memory loss and reduced expression of GABAAR subunits in the adult rat brains. Furthermore, exercise led to significant improvement as compared to short-term BZ treatment.http://dx.doi.org/10.1155/2017/5715816 |
| spellingShingle | Cui Yan Lu De Xiang Liu Hong Jiang Fang Pan Cyrus S. H. Ho Roger C. M. Ho Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain Neural Plasticity |
| title | Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain |
| title_full | Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain |
| title_fullStr | Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain |
| title_full_unstemmed | Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain |
| title_short | Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain |
| title_sort | effects of traumatic stress induced in the juvenile period on the expression of gamma aminobutyric acid receptor type a subunits in adult rat brain |
| url | http://dx.doi.org/10.1155/2017/5715816 |
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