Epithelial-mesenchymal transition in asthma: its role and underlying regulatory mechanisms
Bronchial asthma (asthma) is a respiratory disease characterized by chronic inflammation, airway hyperresponsiveness, and airway remodeling. Numerous studies have delved into asthma’s pathogenesis, among which epithelial mesenchymal transition (EMT) is considered one of the important mechanisms in t...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1519998/full |
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| author | Bingxi Zhang Bingxi Zhang Xinru Feng Lincha Tian Bo Xiao Lixia Hou Biwen Mo Biwen Mo Biwen Mo Dong Yao Dong Yao Dong Yao |
| author_facet | Bingxi Zhang Bingxi Zhang Xinru Feng Lincha Tian Bo Xiao Lixia Hou Biwen Mo Biwen Mo Biwen Mo Dong Yao Dong Yao Dong Yao |
| author_sort | Bingxi Zhang |
| collection | DOAJ |
| description | Bronchial asthma (asthma) is a respiratory disease characterized by chronic inflammation, airway hyperresponsiveness, and airway remodeling. Numerous studies have delved into asthma’s pathogenesis, among which epithelial mesenchymal transition (EMT) is considered one of the important mechanisms in the pathogenesis of asthma. EMT refers to the transformation of epithelial cells, which lose their original features and acquire a migratory and invasive stromal phenotype. EMT contributes to normal physiological functions like growth, development, and wound healing. However, EMT is also involved in the occurrence and development of many diseases. Currently, the precise regulatory mechanism linking EMT and asthma remain obscure. Increasing evidence suggests that airway EMT contributes to asthma pathogenesis via dysregulation of associated control mechanisms. This review explores EMT’s significance in asthma and the regulatory networks associated with EMT in this context. |
| format | Article |
| id | doaj-art-3225648cb48041ebb1c2d30fbb2807da |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-3225648cb48041ebb1c2d30fbb2807da2025-01-22T05:19:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15199981519998Epithelial-mesenchymal transition in asthma: its role and underlying regulatory mechanismsBingxi Zhang0Bingxi Zhang1Xinru Feng2Lincha Tian3Bo Xiao4Lixia Hou5Biwen Mo6Biwen Mo7Biwen Mo8Dong Yao9Dong Yao10Dong Yao11Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaThe Laboratory of Respiratory Disease, Affiliated Hospital of Guilin Medical University, Guilin, ChinaDepartment of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaDepartment of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaThe Laboratory of Respiratory Disease, Affiliated Hospital of Guilin Medical University, Guilin, ChinaThe Laboratory of Respiratory Disease, Affiliated Hospital of Guilin Medical University, Guilin, ChinaDepartment of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaGuangxi Clinical Research Center for Diabetes and Metabolic Diseases, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaGuangxi Key Laboratory of Metabolic Reprogramming and Intelligent Medical Engineering for Chronic Diseases, The Key Laboratory of Respiratory Diseases, Education Department of Guangxi Zhuang Autonomous Region, Guilin Medical University, Guilin, ChinaDepartment of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaGuangxi Clinical Research Center for Diabetes and Metabolic Diseases, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, ChinaGuangxi Key Laboratory of Metabolic Reprogramming and Intelligent Medical Engineering for Chronic Diseases, The Key Laboratory of Respiratory Diseases, Education Department of Guangxi Zhuang Autonomous Region, Guilin Medical University, Guilin, ChinaBronchial asthma (asthma) is a respiratory disease characterized by chronic inflammation, airway hyperresponsiveness, and airway remodeling. Numerous studies have delved into asthma’s pathogenesis, among which epithelial mesenchymal transition (EMT) is considered one of the important mechanisms in the pathogenesis of asthma. EMT refers to the transformation of epithelial cells, which lose their original features and acquire a migratory and invasive stromal phenotype. EMT contributes to normal physiological functions like growth, development, and wound healing. However, EMT is also involved in the occurrence and development of many diseases. Currently, the precise regulatory mechanism linking EMT and asthma remain obscure. Increasing evidence suggests that airway EMT contributes to asthma pathogenesis via dysregulation of associated control mechanisms. This review explores EMT’s significance in asthma and the regulatory networks associated with EMT in this context.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1519998/fullasthmaairway inflammationairway remodelingepithelial-mesenchymal transitionmechanismsignaling pathways |
| spellingShingle | Bingxi Zhang Bingxi Zhang Xinru Feng Lincha Tian Bo Xiao Lixia Hou Biwen Mo Biwen Mo Biwen Mo Dong Yao Dong Yao Dong Yao Epithelial-mesenchymal transition in asthma: its role and underlying regulatory mechanisms Frontiers in Immunology asthma airway inflammation airway remodeling epithelial-mesenchymal transition mechanism signaling pathways |
| title | Epithelial-mesenchymal transition in asthma: its role and underlying regulatory mechanisms |
| title_full | Epithelial-mesenchymal transition in asthma: its role and underlying regulatory mechanisms |
| title_fullStr | Epithelial-mesenchymal transition in asthma: its role and underlying regulatory mechanisms |
| title_full_unstemmed | Epithelial-mesenchymal transition in asthma: its role and underlying regulatory mechanisms |
| title_short | Epithelial-mesenchymal transition in asthma: its role and underlying regulatory mechanisms |
| title_sort | epithelial mesenchymal transition in asthma its role and underlying regulatory mechanisms |
| topic | asthma airway inflammation airway remodeling epithelial-mesenchymal transition mechanism signaling pathways |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1519998/full |
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