An Unusual Case of Recurrent Hypersensitivity Reaction Associated with Kounis-Like Acute Coronary Syndrome
There have been multiple reports of allergic reactions associated with acute coronary syndromes. This has been classically described as Kounis syndrome. We present an unusual case of 70-year-old male with multiple prior hypersensitivity reactions and history of coronary artery bypass grafting who pr...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2017/6421208 |
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| _version_ | 1832549845508816896 |
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| author | Shanker Kundumadam Vivek Reddy Sagar Mallikethi Reddy Pradeep Kathi Aiden Abidov |
| author_facet | Shanker Kundumadam Vivek Reddy Sagar Mallikethi Reddy Pradeep Kathi Aiden Abidov |
| author_sort | Shanker Kundumadam |
| collection | DOAJ |
| description | There have been multiple reports of allergic reactions associated with acute coronary syndromes. This has been classically described as Kounis syndrome. We present an unusual case of 70-year-old male with multiple prior hypersensitivity reactions and history of coronary artery bypass grafting who presented recurrent episode of severe angioedema and anaphylaxis. He responded to epinephrine but subsequently developed a non-ST elevation myocardial infarction with worsening heart failure. Our case is unique in that, unlike classic Kounis syndrome, the acute coronary event in this case did not present concurrently with the allergic reaction; rather it took nearly 48 hours to present. Subsequent angiogram revealed patent grafts and significant decline in the left ventricular systolic function as compared to his own ECHO a year ago. We postulate that slow mediators of inflammation may play a role in delayed development of acute coronary events with associated LV dysfunction following episodes of angioedema and anaphylaxis. |
| format | Article |
| id | doaj-art-321f6530a4ba4159b7117727b87cf333 |
| institution | Kabale University |
| issn | 2090-6404 2090-6412 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-321f6530a4ba4159b7117727b87cf3332025-02-03T06:08:21ZengWileyCase Reports in Cardiology2090-64042090-64122017-01-01201710.1155/2017/64212086421208An Unusual Case of Recurrent Hypersensitivity Reaction Associated with Kounis-Like Acute Coronary SyndromeShanker Kundumadam0Vivek Reddy1Sagar Mallikethi Reddy2Pradeep Kathi3Aiden Abidov4Wayne State University School of Medicine, Detroit, MI, USAWayne State University School of Medicine, Detroit, MI, USAWayne State University School of Medicine, Detroit, MI, USAWayne State University School of Medicine, Detroit, MI, USACardiology, John D. Dingell VA Medical Center, Wayne State University, Detroit, MI, USAThere have been multiple reports of allergic reactions associated with acute coronary syndromes. This has been classically described as Kounis syndrome. We present an unusual case of 70-year-old male with multiple prior hypersensitivity reactions and history of coronary artery bypass grafting who presented recurrent episode of severe angioedema and anaphylaxis. He responded to epinephrine but subsequently developed a non-ST elevation myocardial infarction with worsening heart failure. Our case is unique in that, unlike classic Kounis syndrome, the acute coronary event in this case did not present concurrently with the allergic reaction; rather it took nearly 48 hours to present. Subsequent angiogram revealed patent grafts and significant decline in the left ventricular systolic function as compared to his own ECHO a year ago. We postulate that slow mediators of inflammation may play a role in delayed development of acute coronary events with associated LV dysfunction following episodes of angioedema and anaphylaxis.http://dx.doi.org/10.1155/2017/6421208 |
| spellingShingle | Shanker Kundumadam Vivek Reddy Sagar Mallikethi Reddy Pradeep Kathi Aiden Abidov An Unusual Case of Recurrent Hypersensitivity Reaction Associated with Kounis-Like Acute Coronary Syndrome Case Reports in Cardiology |
| title | An Unusual Case of Recurrent Hypersensitivity Reaction Associated with Kounis-Like Acute Coronary Syndrome |
| title_full | An Unusual Case of Recurrent Hypersensitivity Reaction Associated with Kounis-Like Acute Coronary Syndrome |
| title_fullStr | An Unusual Case of Recurrent Hypersensitivity Reaction Associated with Kounis-Like Acute Coronary Syndrome |
| title_full_unstemmed | An Unusual Case of Recurrent Hypersensitivity Reaction Associated with Kounis-Like Acute Coronary Syndrome |
| title_short | An Unusual Case of Recurrent Hypersensitivity Reaction Associated with Kounis-Like Acute Coronary Syndrome |
| title_sort | unusual case of recurrent hypersensitivity reaction associated with kounis like acute coronary syndrome |
| url | http://dx.doi.org/10.1155/2017/6421208 |
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