Immune-Mediated Neutropenia and Thrombocytopenia in a Patient with Ulcerative Colitis: An Unusual Hematological Association with IBD
Hematological manifestations of inflammatory bowel disease (IBD) are well described in the literature. However, the combination of immune-mediated neutropenia and thrombocytopenia has only been reported once in association with IBD. A case is reported of immune-mediated neutropenia and thrombocytope...
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| Format: | Article |
| Language: | English |
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Wiley
1995-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1995/820420 |
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| author | Young-In Kim Aaron Brzezinski Joseph Brandwein Jeffrey P Baker |
| author_facet | Young-In Kim Aaron Brzezinski Joseph Brandwein Jeffrey P Baker |
| author_sort | Young-In Kim |
| collection | DOAJ |
| description | Hematological manifestations of inflammatory bowel disease (IBD) are well described in the literature. However, the combination of immune-mediated neutropenia and thrombocytopenia has only been reported once in association with IBD. A case is reported of immune-mediated neutropenia and thrombocytopenia in a patient with ulcerative colitis during a relapse. No obvious causes of these hematological abnormalities were found in the patient despite an exhaustive search. An immune-mediated process was confirmed by positive antineutrophil antibody and platelet-associated antibody in the patient’s serum, and the demonstration of binding of the patient’s immunoglobulin G to autologous neutrophils. The patient was treated with high-dose steroid, intravenous gamma-globulin and eventually splenectomy. The platelet count subsequently normalized; although the severe neutropenia recurred, it has subsequently improved without further treatment. Although a definitive cause-effect relationship cannot be established, the immune-mediated neutropenia and thrombocytopenia may be an unusual hematological manifestation associated with ulcerative colitis. |
| format | Article |
| id | doaj-art-321ecd1181784a4c91f33f0bdf9df93c |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-321ecd1181784a4c91f33f0bdf9df93c2025-02-03T05:57:48ZengWileyCanadian Journal of Gastroenterology0835-79001995-01-01929610010.1155/1995/820420Immune-Mediated Neutropenia and Thrombocytopenia in a Patient with Ulcerative Colitis: An Unusual Hematological Association with IBDYoung-In Kim0Aaron Brzezinski1Joseph Brandwein2Jeffrey P Baker3Division of Gastroenterology and Hematology, Department of Medicine, St Michael’s Hospital, University of Toronto, Toronto, Ontario, CanadaDivision of Gastroenterology and Hematology, Department of Medicine, St Michael’s Hospital, University of Toronto, Toronto, Ontario, CanadaDivision of Hematology, Department of Medicine, St Michael’s Hospital, University of Toronto, Toronto, Ontario, CanadaDivision of Gastroenterology and Hematology, Department of Medicine, St Michael’s Hospital, University of Toronto, Toronto, Ontario, CanadaHematological manifestations of inflammatory bowel disease (IBD) are well described in the literature. However, the combination of immune-mediated neutropenia and thrombocytopenia has only been reported once in association with IBD. A case is reported of immune-mediated neutropenia and thrombocytopenia in a patient with ulcerative colitis during a relapse. No obvious causes of these hematological abnormalities were found in the patient despite an exhaustive search. An immune-mediated process was confirmed by positive antineutrophil antibody and platelet-associated antibody in the patient’s serum, and the demonstration of binding of the patient’s immunoglobulin G to autologous neutrophils. The patient was treated with high-dose steroid, intravenous gamma-globulin and eventually splenectomy. The platelet count subsequently normalized; although the severe neutropenia recurred, it has subsequently improved without further treatment. Although a definitive cause-effect relationship cannot be established, the immune-mediated neutropenia and thrombocytopenia may be an unusual hematological manifestation associated with ulcerative colitis.http://dx.doi.org/10.1155/1995/820420 |
| spellingShingle | Young-In Kim Aaron Brzezinski Joseph Brandwein Jeffrey P Baker Immune-Mediated Neutropenia and Thrombocytopenia in a Patient with Ulcerative Colitis: An Unusual Hematological Association with IBD Canadian Journal of Gastroenterology |
| title | Immune-Mediated Neutropenia and Thrombocytopenia in a Patient with Ulcerative Colitis: An Unusual Hematological Association with IBD |
| title_full | Immune-Mediated Neutropenia and Thrombocytopenia in a Patient with Ulcerative Colitis: An Unusual Hematological Association with IBD |
| title_fullStr | Immune-Mediated Neutropenia and Thrombocytopenia in a Patient with Ulcerative Colitis: An Unusual Hematological Association with IBD |
| title_full_unstemmed | Immune-Mediated Neutropenia and Thrombocytopenia in a Patient with Ulcerative Colitis: An Unusual Hematological Association with IBD |
| title_short | Immune-Mediated Neutropenia and Thrombocytopenia in a Patient with Ulcerative Colitis: An Unusual Hematological Association with IBD |
| title_sort | immune mediated neutropenia and thrombocytopenia in a patient with ulcerative colitis an unusual hematological association with ibd |
| url | http://dx.doi.org/10.1155/1995/820420 |
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