Emerging Pharmacological Interventions for Chronic Venous Insufficiency: A Comprehensive Systematic Review and Meta-Analysis of Efficacy, Safety, and Therapeutic Advances
<b>Background/Objectives:</b> Chronic Venous Insufficiency (CVI) is a progressive vascular condition characterized by venous hypertension and chronic inflammation, leading to significant clinical and socioeconomic impacts. This study aimed to evaluate the efficacy and safety of emerging...
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| author | Camila Botelho Miguel Ranielly de Souza Andrade Laise Mazurek Melissa Carvalho Martins-de-Abreu Jamil Miguel-Neto Aurélio de Melo Barbosa Glicélia Pereira Silva Aristóteles Góes-Neto Siomar de Castro Soares Javier Emilio Lazo-Chica Wellington Francisco Rodrigues |
| author_facet | Camila Botelho Miguel Ranielly de Souza Andrade Laise Mazurek Melissa Carvalho Martins-de-Abreu Jamil Miguel-Neto Aurélio de Melo Barbosa Glicélia Pereira Silva Aristóteles Góes-Neto Siomar de Castro Soares Javier Emilio Lazo-Chica Wellington Francisco Rodrigues |
| author_sort | Camila Botelho Miguel |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Chronic Venous Insufficiency (CVI) is a progressive vascular condition characterized by venous hypertension and chronic inflammation, leading to significant clinical and socioeconomic impacts. This study aimed to evaluate the efficacy and safety of emerging pharmacological interventions for CVI, focusing on clinical outcomes such as pain, edema, cutaneous blood flow, and quality of life. <b>Methods:</b> Eligible interventions comprised new vasoprotective drugs, such as hydroxyethylrutoside, Pycnogenol, aminaphthone, coumarin + troxerutin, and Venoruton, compared to the standard therapy of diosmin and hesperidin. <b>Results</b>: Hydroxyethylrutoside and Pycnogenol showed significant benefits in pain reduction and resting flux improvement, with mean differences of 38 (95% CI: 10.56–65.44) and 25.30 (95% CI: 18.73–31.87), respectively. Improvements in edema and quality of life were less consistent. Substantial heterogeneity was observed (I<sup>2</sup> = 100%, <i>p</i> < 0.001). Conclusions: Hydroxyethylrutoside and Pycnogenol emerge as promising alternatives for managing CVI. However, limitations such as high heterogeneity, small sample sizes, and methodological inconsistencies highlight the need for more robust and standardized clinical trials. This study underscores the importance of personalized and cost-effective strategies, particularly in resource-limited settings. |
| format | Article |
| id | doaj-art-32190413cacc44aaba3887aad5b90571 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-32190413cacc44aaba3887aad5b905712025-01-24T13:45:45ZengMDPI AGPharmaceutics1999-49232025-01-011715910.3390/pharmaceutics17010059Emerging Pharmacological Interventions for Chronic Venous Insufficiency: A Comprehensive Systematic Review and Meta-Analysis of Efficacy, Safety, and Therapeutic AdvancesCamila Botelho Miguel0Ranielly de Souza Andrade1Laise Mazurek2Melissa Carvalho Martins-de-Abreu3Jamil Miguel-Neto4Aurélio de Melo Barbosa5Glicélia Pereira Silva6Aristóteles Góes-Neto7Siomar de Castro Soares8Javier Emilio Lazo-Chica9Wellington Francisco Rodrigues10Multidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, BrazilMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, BrazilPostgraduate Program in Tropical Medicine and Infectious Diseases, Federal University of the Triângulo Mineiro—UFTM, Uberaba 38025-180, MG, BrazilMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, BrazilMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, BrazilFaculty of Physiotherapy, Universidade Estadual de Goiás—UEG, Goiânia 74015-908, GO, BrazilMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, BrazilDepartment of Microbiology, Molecular and Computational Biology of Fungi Laboratory, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, BrazilPostgraduate Program in Tropical Medicine and Infectious Diseases, Federal University of the Triângulo Mineiro—UFTM, Uberaba 38025-180, MG, BrazilLaboratory of Cell Biology, Department of Structural Biology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba 38061-500, MG, BrazilMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, Brazil<b>Background/Objectives:</b> Chronic Venous Insufficiency (CVI) is a progressive vascular condition characterized by venous hypertension and chronic inflammation, leading to significant clinical and socioeconomic impacts. This study aimed to evaluate the efficacy and safety of emerging pharmacological interventions for CVI, focusing on clinical outcomes such as pain, edema, cutaneous blood flow, and quality of life. <b>Methods:</b> Eligible interventions comprised new vasoprotective drugs, such as hydroxyethylrutoside, Pycnogenol, aminaphthone, coumarin + troxerutin, and Venoruton, compared to the standard therapy of diosmin and hesperidin. <b>Results</b>: Hydroxyethylrutoside and Pycnogenol showed significant benefits in pain reduction and resting flux improvement, with mean differences of 38 (95% CI: 10.56–65.44) and 25.30 (95% CI: 18.73–31.87), respectively. Improvements in edema and quality of life were less consistent. Substantial heterogeneity was observed (I<sup>2</sup> = 100%, <i>p</i> < 0.001). Conclusions: Hydroxyethylrutoside and Pycnogenol emerge as promising alternatives for managing CVI. However, limitations such as high heterogeneity, small sample sizes, and methodological inconsistencies highlight the need for more robust and standardized clinical trials. This study underscores the importance of personalized and cost-effective strategies, particularly in resource-limited settings.https://www.mdpi.com/1999-4923/17/1/59chronic venous insufficiencyhydroxyethylrutosidePycnogenolvasoprotective drugsmeta-analysis |
| spellingShingle | Camila Botelho Miguel Ranielly de Souza Andrade Laise Mazurek Melissa Carvalho Martins-de-Abreu Jamil Miguel-Neto Aurélio de Melo Barbosa Glicélia Pereira Silva Aristóteles Góes-Neto Siomar de Castro Soares Javier Emilio Lazo-Chica Wellington Francisco Rodrigues Emerging Pharmacological Interventions for Chronic Venous Insufficiency: A Comprehensive Systematic Review and Meta-Analysis of Efficacy, Safety, and Therapeutic Advances Pharmaceutics chronic venous insufficiency hydroxyethylrutoside Pycnogenol vasoprotective drugs meta-analysis |
| title | Emerging Pharmacological Interventions for Chronic Venous Insufficiency: A Comprehensive Systematic Review and Meta-Analysis of Efficacy, Safety, and Therapeutic Advances |
| title_full | Emerging Pharmacological Interventions for Chronic Venous Insufficiency: A Comprehensive Systematic Review and Meta-Analysis of Efficacy, Safety, and Therapeutic Advances |
| title_fullStr | Emerging Pharmacological Interventions for Chronic Venous Insufficiency: A Comprehensive Systematic Review and Meta-Analysis of Efficacy, Safety, and Therapeutic Advances |
| title_full_unstemmed | Emerging Pharmacological Interventions for Chronic Venous Insufficiency: A Comprehensive Systematic Review and Meta-Analysis of Efficacy, Safety, and Therapeutic Advances |
| title_short | Emerging Pharmacological Interventions for Chronic Venous Insufficiency: A Comprehensive Systematic Review and Meta-Analysis of Efficacy, Safety, and Therapeutic Advances |
| title_sort | emerging pharmacological interventions for chronic venous insufficiency a comprehensive systematic review and meta analysis of efficacy safety and therapeutic advances |
| topic | chronic venous insufficiency hydroxyethylrutoside Pycnogenol vasoprotective drugs meta-analysis |
| url | https://www.mdpi.com/1999-4923/17/1/59 |
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