IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels
The central nervous system architecture is markedly modified by sensory experience during early life, but a decline of plasticity occurs with age. Recent studies have challenged this dogma providing evidence that both pharmacological treatments and paradigms based on the manipulation of environmenta...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/250421 |
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| _version_ | 1832553249438171136 |
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| author | José Fernando Maya-Vetencourt Laura Baroncelli Alessandro Viegi Ettore Tiraboschi Eero Castren Antonino Cattaneo Lamberto Maffei |
| author_facet | José Fernando Maya-Vetencourt Laura Baroncelli Alessandro Viegi Ettore Tiraboschi Eero Castren Antonino Cattaneo Lamberto Maffei |
| author_sort | José Fernando Maya-Vetencourt |
| collection | DOAJ |
| description | The central nervous system architecture is markedly modified by sensory experience during early life, but a decline of plasticity occurs with age. Recent studies have challenged this dogma providing evidence that both pharmacological treatments and paradigms based on the manipulation of environmental stimulation levels can be successfully employed as strategies for enhancing plasticity in the adult nervous system. Insulin-like growth factor 1 (IGF-1) is a peptide implicated in prenatal and postnatal phases of brain development such as neurogenesis, neuronal differentiation, synaptogenesis, and experience-dependent plasticity. Here, using the visual system as a paradigmatic model, we report that IGF-1 reactivates neural plasticity in the adult brain. Exogenous administration of IGF-1 in the adult visual cortex, indeed, restores the susceptibility of cortical neurons to monocular deprivation and promotes the recovery of normal visual functions in adult amblyopic animals. These effects were accompanied by a marked reduction of intracortical GABA levels. Moreover, we show that a transitory increase of IGF-1 expression is associated to the plasticity reinstatement induced by environmental enrichment (EE) and that blocking IGF-1 action by means of the IGF-1 receptor antagonist JB1 prevents EE effects on plasticity processes. |
| format | Article |
| id | doaj-art-320c955dc8244494bd77d95a5b6d9399 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-320c955dc8244494bd77d95a5b6d93992025-02-03T05:54:30ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/250421250421IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA LevelsJosé Fernando Maya-Vetencourt0Laura Baroncelli1Alessandro Viegi2Ettore Tiraboschi3Eero Castren4Antonino Cattaneo5Lamberto Maffei6Laboratory of Neurobiology, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56100 Pisa, ItalyInstitute of Neuroscience, CNR, Via Moruzzi 1, 56100 Pisa, ItalyLaboratory of Neurobiology, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56100 Pisa, ItalyNeuroscience Centre, University of Helsinki, 00014 Helsinki, FinlandNeuroscience Centre, University of Helsinki, 00014 Helsinki, FinlandLaboratory of Neurobiology, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56100 Pisa, ItalyLaboratory of Neurobiology, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56100 Pisa, ItalyThe central nervous system architecture is markedly modified by sensory experience during early life, but a decline of plasticity occurs with age. Recent studies have challenged this dogma providing evidence that both pharmacological treatments and paradigms based on the manipulation of environmental stimulation levels can be successfully employed as strategies for enhancing plasticity in the adult nervous system. Insulin-like growth factor 1 (IGF-1) is a peptide implicated in prenatal and postnatal phases of brain development such as neurogenesis, neuronal differentiation, synaptogenesis, and experience-dependent plasticity. Here, using the visual system as a paradigmatic model, we report that IGF-1 reactivates neural plasticity in the adult brain. Exogenous administration of IGF-1 in the adult visual cortex, indeed, restores the susceptibility of cortical neurons to monocular deprivation and promotes the recovery of normal visual functions in adult amblyopic animals. These effects were accompanied by a marked reduction of intracortical GABA levels. Moreover, we show that a transitory increase of IGF-1 expression is associated to the plasticity reinstatement induced by environmental enrichment (EE) and that blocking IGF-1 action by means of the IGF-1 receptor antagonist JB1 prevents EE effects on plasticity processes.http://dx.doi.org/10.1155/2012/250421 |
| spellingShingle | José Fernando Maya-Vetencourt Laura Baroncelli Alessandro Viegi Ettore Tiraboschi Eero Castren Antonino Cattaneo Lamberto Maffei IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels Neural Plasticity |
| title | IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels |
| title_full | IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels |
| title_fullStr | IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels |
| title_full_unstemmed | IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels |
| title_short | IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels |
| title_sort | igf 1 restores visual cortex plasticity in adult life by reducing local gaba levels |
| url | http://dx.doi.org/10.1155/2012/250421 |
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