Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits
Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg−1, i.v.) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determ...
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| Format: | Article |
| Language: | English |
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Sciendo
2021-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2021-0030 |
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| author | Yu Chun Li Donghao Li Zhongyan Yu Donghui Zhai Guijuan |
| author_facet | Yu Chun Li Donghao Li Zhongyan Yu Donghui Zhai Guijuan |
| author_sort | Yu Chun |
| collection | DOAJ |
| description | Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg−1, i.v.) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determined. The cardiac enzymatic anti-oxidant systems were recorded with their electrographic profiles. HR, SBP, DBP and MAP were restored at 5 or 10 mg kg−1 (p.o.) of SAC/VAL compared to DOX, followed by reduced levels of creatinine and BNP (p < 0.001). Significant improvements (p < 0.05) compared to DOX were also noticed in CAT, SOD and LPO with the same doses of SAC/VAL. Specific biomarkers such as BNP, CnT, CRP and ROMs descended significantly (p < 0.001) with treatment when compared to their baseline values. Our findings implied that SAC/VAL treatment reduced the inflammation and oxidative stress to improve the cardiac function. |
| format | Article |
| id | doaj-art-31f7721c50e7449db7d9ac1b97539dce |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-31f7721c50e7449db7d9ac1b97539dce2025-02-02T15:49:11ZengSciendoActa Pharmaceutica1846-95582021-09-0171347348410.2478/acph-2021-0030acph-2021-0030Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbitsYu Chun0Li Donghao1Li Zhongyan2Yu Donghui3Zhai Guijuan4Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, JilinChina, 132103Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, JilinChina, 132103Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, JilinChina, 132103Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, JilinChina, 132103Department of Radiology, Affiliated Hospital of Jilin Medical College, JilinChina, 132103Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg−1, i.v.) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determined. The cardiac enzymatic anti-oxidant systems were recorded with their electrographic profiles. HR, SBP, DBP and MAP were restored at 5 or 10 mg kg−1 (p.o.) of SAC/VAL compared to DOX, followed by reduced levels of creatinine and BNP (p < 0.001). Significant improvements (p < 0.05) compared to DOX were also noticed in CAT, SOD and LPO with the same doses of SAC/VAL. Specific biomarkers such as BNP, CnT, CRP and ROMs descended significantly (p < 0.001) with treatment when compared to their baseline values. Our findings implied that SAC/VAL treatment reduced the inflammation and oxidative stress to improve the cardiac function.https://doi.org/10.2478/acph-2021-0030sacubitrilvalsartandoxorubicin-heart failureinflammationoxidative stressnatriuretic peptide |
| spellingShingle | Yu Chun Li Donghao Li Zhongyan Yu Donghui Zhai Guijuan Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits Acta Pharmaceutica sacubitril valsartan doxorubicin-heart failure inflammation oxidative stress natriuretic peptide |
| title | Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits |
| title_full | Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits |
| title_fullStr | Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits |
| title_full_unstemmed | Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits |
| title_short | Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits |
| title_sort | effect of sacubitril valsartan on inflammation and oxidative stress in doxorubicin induced heart failure model in rabbits |
| topic | sacubitril valsartan doxorubicin-heart failure inflammation oxidative stress natriuretic peptide |
| url | https://doi.org/10.2478/acph-2021-0030 |
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