Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits

Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg−1, i.v.) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determ...

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Main Authors: Yu Chun, Li Donghao, Li Zhongyan, Yu Donghui, Zhai Guijuan
Format: Article
Language:English
Published: Sciendo 2021-09-01
Series:Acta Pharmaceutica
Subjects:
Online Access:https://doi.org/10.2478/acph-2021-0030
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author Yu Chun
Li Donghao
Li Zhongyan
Yu Donghui
Zhai Guijuan
author_facet Yu Chun
Li Donghao
Li Zhongyan
Yu Donghui
Zhai Guijuan
author_sort Yu Chun
collection DOAJ
description Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg−1, i.v.) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determined. The cardiac enzymatic anti-oxidant systems were recorded with their electrographic profiles. HR, SBP, DBP and MAP were restored at 5 or 10 mg kg−1 (p.o.) of SAC/VAL compared to DOX, followed by reduced levels of creatinine and BNP (p < 0.001). Significant improvements (p < 0.05) compared to DOX were also noticed in CAT, SOD and LPO with the same doses of SAC/VAL. Specific biomarkers such as BNP, CnT, CRP and ROMs descended significantly (p < 0.001) with treatment when compared to their baseline values. Our findings implied that SAC/VAL treatment reduced the inflammation and oxidative stress to improve the cardiac function.
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spelling doaj-art-31f7721c50e7449db7d9ac1b97539dce2025-02-02T15:49:11ZengSciendoActa Pharmaceutica1846-95582021-09-0171347348410.2478/acph-2021-0030acph-2021-0030Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbitsYu Chun0Li Donghao1Li Zhongyan2Yu Donghui3Zhai Guijuan4Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, JilinChina, 132103Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, JilinChina, 132103Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, JilinChina, 132103Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, JilinChina, 132103Department of Radiology, Affiliated Hospital of Jilin Medical College, JilinChina, 132103Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg−1, i.v.) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determined. The cardiac enzymatic anti-oxidant systems were recorded with their electrographic profiles. HR, SBP, DBP and MAP were restored at 5 or 10 mg kg−1 (p.o.) of SAC/VAL compared to DOX, followed by reduced levels of creatinine and BNP (p < 0.001). Significant improvements (p < 0.05) compared to DOX were also noticed in CAT, SOD and LPO with the same doses of SAC/VAL. Specific biomarkers such as BNP, CnT, CRP and ROMs descended significantly (p < 0.001) with treatment when compared to their baseline values. Our findings implied that SAC/VAL treatment reduced the inflammation and oxidative stress to improve the cardiac function.https://doi.org/10.2478/acph-2021-0030sacubitrilvalsartandoxorubicin-heart failureinflammationoxidative stressnatriuretic peptide
spellingShingle Yu Chun
Li Donghao
Li Zhongyan
Yu Donghui
Zhai Guijuan
Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits
Acta Pharmaceutica
sacubitril
valsartan
doxorubicin-heart failure
inflammation
oxidative stress
natriuretic peptide
title Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits
title_full Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits
title_fullStr Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits
title_full_unstemmed Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits
title_short Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits
title_sort effect of sacubitril valsartan on inflammation and oxidative stress in doxorubicin induced heart failure model in rabbits
topic sacubitril
valsartan
doxorubicin-heart failure
inflammation
oxidative stress
natriuretic peptide
url https://doi.org/10.2478/acph-2021-0030
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AT lidonghao effectofsacubitrilvalsartanoninflammationandoxidativestressindoxorubicininducedheartfailuremodelinrabbits
AT lizhongyan effectofsacubitrilvalsartanoninflammationandoxidativestressindoxorubicininducedheartfailuremodelinrabbits
AT yudonghui effectofsacubitrilvalsartanoninflammationandoxidativestressindoxorubicininducedheartfailuremodelinrabbits
AT zhaiguijuan effectofsacubitrilvalsartanoninflammationandoxidativestressindoxorubicininducedheartfailuremodelinrabbits