GPER1-mediated suppression of acute cellular rejection in murine cervical heart transplantation by estradiol

GPER1-mediated suppression of acute cellular rejection in murine cervical heart transplantation by estradiol

Abstract Objective This study aimed to investigate the inhibitory effect of estradiol (E2) on acute cellular rejection following murine cervical heart transplantation and the role of G protein-coupled estrogen receptor 1 (GPER1). Method A murine cervical heart transplantation model was established a...

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Bibliographic Details
Main Authors: Yiwei Liu, Ran Wang, Bater Han, Benben Zhu, Yu Ma, Yongjun Yu, Lu Bai, Qiyou Wei, Pengjie Yang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Cardiothoracic Surgery
Subjects:
Estradiol
GPER1
Heart transplantation
Immunosuppression
Treg cells
Transplantation immunity.
Online Access:https://doi.org/10.1186/s13019-025-03432-8
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https://doi.org/10.1186/s13019-025-03432-8

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