Appetite Response among Those Susceptible or Resistant to Obesity
An alternative approach in determining cause, treatment, and prevention of obesity is to study those who appear resistant to the obesogenic environment. We examined appetite responses in 33 obesity resistant individuals (ORI) versus 28 obesity susceptible individuals (OSI). Fingerprick blood samples...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/512013 |
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| author | Rachel C. Brown Rebecca T. McLay-Cooke Sara L. Richardson Sheila M. Williams David R. Grattan Alexandra W.-A. H. Chisholm |
| author_facet | Rachel C. Brown Rebecca T. McLay-Cooke Sara L. Richardson Sheila M. Williams David R. Grattan Alexandra W.-A. H. Chisholm |
| author_sort | Rachel C. Brown |
| collection | DOAJ |
| description | An alternative approach in determining cause, treatment, and prevention of obesity is to study those who appear resistant to the obesogenic environment. We examined appetite responses in 33 obesity resistant individuals (ORI) versus 28 obesity susceptible individuals (OSI). Fingerprick blood samples to measure ghrelin, total peptide YY (PYY), leptin, glucose, and insulin along with appetite ratings were collected at baseline and 15, 30, 60, 120, and 180 min following consumption of a standardized meal. Fasting, area under the curve (AUC), peak/nadir, and time to peak/nadir were compared. Participants completed the three factor eating questionnaire (TFEQ). No significant differences were observed for ghrelin or PYY. Higher leptin concentrations in the OSI disappeared after controlling for percent body fat (%BF). Significant differences in appetite ratings included a lower hunger nadir among OSI compared with ORI (P=0.017). Dietary restraint (P<0.001) and disinhibition (P<0.001) were lower in ORI compared with OSI, with and without adjustment for %BF. Given the differential body weight of the study groups, similar observed ghrelin concentrations were unexpected, perhaps indicating OSI and ORI respond differently to the same ghrelin concentration. Also ORI response to hunger appears different as they exhibit lower levels of dietary restraint and disinhibition compared with OSI. |
| format | Article |
| id | doaj-art-31e65ce72cb34e1780d4c1e43d9cbe28 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-31e65ce72cb34e1780d4c1e43d9cbe282025-02-03T00:59:29ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/512013512013Appetite Response among Those Susceptible or Resistant to ObesityRachel C. Brown0Rebecca T. McLay-Cooke1Sara L. Richardson2Sheila M. Williams3David R. Grattan4Alexandra W.-A. H. Chisholm5Department of Human Nutrition, University of Otago, P.O. Box 56, Dunedin 9054, New ZealandDepartment of Human Nutrition, University of Otago, P.O. Box 56, Dunedin 9054, New ZealandDepartment of Human Nutrition, University of Otago, P.O. Box 56, Dunedin 9054, New ZealandDepartment of Preventive and Social Medicine, University of Otago, P.O. Box 56, Dunedin 9054, New ZealandDepartment of Anatomy, University of Otago, P.O. Box 56, Dunedin 9054, New ZealandDepartment of Human Nutrition, University of Otago, P.O. Box 56, Dunedin 9054, New ZealandAn alternative approach in determining cause, treatment, and prevention of obesity is to study those who appear resistant to the obesogenic environment. We examined appetite responses in 33 obesity resistant individuals (ORI) versus 28 obesity susceptible individuals (OSI). Fingerprick blood samples to measure ghrelin, total peptide YY (PYY), leptin, glucose, and insulin along with appetite ratings were collected at baseline and 15, 30, 60, 120, and 180 min following consumption of a standardized meal. Fasting, area under the curve (AUC), peak/nadir, and time to peak/nadir were compared. Participants completed the three factor eating questionnaire (TFEQ). No significant differences were observed for ghrelin or PYY. Higher leptin concentrations in the OSI disappeared after controlling for percent body fat (%BF). Significant differences in appetite ratings included a lower hunger nadir among OSI compared with ORI (P=0.017). Dietary restraint (P<0.001) and disinhibition (P<0.001) were lower in ORI compared with OSI, with and without adjustment for %BF. Given the differential body weight of the study groups, similar observed ghrelin concentrations were unexpected, perhaps indicating OSI and ORI respond differently to the same ghrelin concentration. Also ORI response to hunger appears different as they exhibit lower levels of dietary restraint and disinhibition compared with OSI.http://dx.doi.org/10.1155/2014/512013 |
| spellingShingle | Rachel C. Brown Rebecca T. McLay-Cooke Sara L. Richardson Sheila M. Williams David R. Grattan Alexandra W.-A. H. Chisholm Appetite Response among Those Susceptible or Resistant to Obesity International Journal of Endocrinology |
| title | Appetite Response among Those Susceptible or Resistant to Obesity |
| title_full | Appetite Response among Those Susceptible or Resistant to Obesity |
| title_fullStr | Appetite Response among Those Susceptible or Resistant to Obesity |
| title_full_unstemmed | Appetite Response among Those Susceptible or Resistant to Obesity |
| title_short | Appetite Response among Those Susceptible or Resistant to Obesity |
| title_sort | appetite response among those susceptible or resistant to obesity |
| url | http://dx.doi.org/10.1155/2014/512013 |
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