Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma?
Basal cell carcinoma (BCC) accounts for 80% of all nonmelanoma skin cancers. Its metastasis is extremely rare, ranging between 0.0028 and 0.55 of all BCC cases. The usual metastasis to lymph nodes, lungs, bones, or skin is from the primary tumor situated in the head and neck region in nearly 85% cas...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/157187 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549845009694720 |
|---|---|
| author | Karaninder S. Mehta Vikram K. Mahajan Pushpinder S. Chauhan Anju Lath Sharma Vikas Sharma C. Abhinav Gayatri Khatri Neel Prabha Saurabh Sharma Muninder Negi |
| author_facet | Karaninder S. Mehta Vikram K. Mahajan Pushpinder S. Chauhan Anju Lath Sharma Vikas Sharma C. Abhinav Gayatri Khatri Neel Prabha Saurabh Sharma Muninder Negi |
| author_sort | Karaninder S. Mehta |
| collection | DOAJ |
| description | Basal cell carcinoma (BCC) accounts for 80% of all nonmelanoma skin cancers. Its metastasis is extremely rare, ranging between 0.0028 and 0.55 of all BCC cases. The usual metastasis to lymph nodes, lungs, bones, or skin is from the primary tumor situated in the head and neck region in nearly 85% cases. A 69-year-old male developed progressively increasing multiple, fleshy, indurated, and at places pigmented noduloulcerative plaques over back, chest, and left axillary area 4 years after wide surgical excision of a pathologically diagnosed basal cell carcinoma. The recurrence was diagnosed as infiltrative BCC and found metastasizing to skin, soft tissue and muscles, and pretracheal and axillary lymph nodes. Three cycles of chemotherapy comprising intravenous cisplatin (50 mg) and 5-florouracil (5-FU, 750 mg) on 2 consecutive days and repeated at every 21 days were effective. As it remains unclear whether metastatic BCC is itself a separate subset of basal cell carcinoma, we feel that early BCC localized at any site perhaps constitutes a biological continuum that may ultimately manifest with metastasis in some individuals and should be evaluated as such. Long-standing BCC is itself potentially at risk of recurrence/dissemination; it is imperative to diagnose and appropriately treat all BCC lesions at the earliest. |
| format | Article |
| id | doaj-art-31b8f51e874a4a259bea5a2dcff6a6f4 |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-31b8f51e874a4a259bea5a2dcff6a6f42025-02-03T06:08:20ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712012-01-01201210.1155/2012/157187157187Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma?Karaninder S. Mehta0Vikram K. Mahajan1Pushpinder S. Chauhan2Anju Lath Sharma3Vikas Sharma4C. Abhinav5Gayatri Khatri6Neel Prabha7Saurabh Sharma8Muninder Negi9Department of Dermatology, Venereology and Leprosy, Dr. RP Government Medical College, Kangra, Tanda 176001, Himachal Pradesh, IndiaDepartment of Dermatology, Venereology and Leprosy, Dr. RP Government Medical College, Kangra, Tanda 176001, Himachal Pradesh, IndiaDepartment of Dermatology, Venereology and Leprosy, Dr. RP Government Medical College, Kangra, Tanda 176001, Himachal Pradesh, IndiaDepartment of Dermatology, Venereology and Leprosy, Dr. RP Government Medical College, Kangra, Tanda 176001, Himachal Pradesh, IndiaDepartment of Dermatology, Venereology and Leprosy, Dr. RP Government Medical College, Kangra, Tanda 176001, Himachal Pradesh, IndiaDepartment of Dermatology, Venereology and Leprosy, Dr. RP Government Medical College, Kangra, Tanda 176001, Himachal Pradesh, IndiaDepartment of Dermatology, Venereology and Leprosy, Dr. RP Government Medical College, Kangra, Tanda 176001, Himachal Pradesh, IndiaDepartment of Dermatology, Venereology and Leprosy, Dr. RP Government Medical College, Kangra, Tanda 176001, Himachal Pradesh, IndiaDepartment of Pathology, Dr. RP Government Medical College, Kangra, Tanda 176001, Himachal Pradesh, IndiaDepartment of Radiotherapy and Oncology, Dr. RP Government Medical College, Kangra, Tanda 176001, Himachal Pradesh, IndiaBasal cell carcinoma (BCC) accounts for 80% of all nonmelanoma skin cancers. Its metastasis is extremely rare, ranging between 0.0028 and 0.55 of all BCC cases. The usual metastasis to lymph nodes, lungs, bones, or skin is from the primary tumor situated in the head and neck region in nearly 85% cases. A 69-year-old male developed progressively increasing multiple, fleshy, indurated, and at places pigmented noduloulcerative plaques over back, chest, and left axillary area 4 years after wide surgical excision of a pathologically diagnosed basal cell carcinoma. The recurrence was diagnosed as infiltrative BCC and found metastasizing to skin, soft tissue and muscles, and pretracheal and axillary lymph nodes. Three cycles of chemotherapy comprising intravenous cisplatin (50 mg) and 5-florouracil (5-FU, 750 mg) on 2 consecutive days and repeated at every 21 days were effective. As it remains unclear whether metastatic BCC is itself a separate subset of basal cell carcinoma, we feel that early BCC localized at any site perhaps constitutes a biological continuum that may ultimately manifest with metastasis in some individuals and should be evaluated as such. Long-standing BCC is itself potentially at risk of recurrence/dissemination; it is imperative to diagnose and appropriately treat all BCC lesions at the earliest.http://dx.doi.org/10.1155/2012/157187 |
| spellingShingle | Karaninder S. Mehta Vikram K. Mahajan Pushpinder S. Chauhan Anju Lath Sharma Vikas Sharma C. Abhinav Gayatri Khatri Neel Prabha Saurabh Sharma Muninder Negi Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma? Case Reports in Dermatological Medicine |
| title | Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma? |
| title_full | Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma? |
| title_fullStr | Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma? |
| title_full_unstemmed | Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma? |
| title_short | Metastatic Basal Cell Carcinoma: A Biological Continuum of Basal Cell Carcinoma? |
| title_sort | metastatic basal cell carcinoma a biological continuum of basal cell carcinoma |
| url | http://dx.doi.org/10.1155/2012/157187 |
| work_keys_str_mv | AT karanindersmehta metastaticbasalcellcarcinomaabiologicalcontinuumofbasalcellcarcinoma AT vikramkmahajan metastaticbasalcellcarcinomaabiologicalcontinuumofbasalcellcarcinoma AT pushpinderschauhan metastaticbasalcellcarcinomaabiologicalcontinuumofbasalcellcarcinoma AT anjulathsharma metastaticbasalcellcarcinomaabiologicalcontinuumofbasalcellcarcinoma AT vikassharma metastaticbasalcellcarcinomaabiologicalcontinuumofbasalcellcarcinoma AT cabhinav metastaticbasalcellcarcinomaabiologicalcontinuumofbasalcellcarcinoma AT gayatrikhatri metastaticbasalcellcarcinomaabiologicalcontinuumofbasalcellcarcinoma AT neelprabha metastaticbasalcellcarcinomaabiologicalcontinuumofbasalcellcarcinoma AT saurabhsharma metastaticbasalcellcarcinomaabiologicalcontinuumofbasalcellcarcinoma AT munindernegi metastaticbasalcellcarcinomaabiologicalcontinuumofbasalcellcarcinoma |