Application and prospects of genetic engineering in CAR-NK cell therapy

Application and prospects of genetic engineering in CAR-NK cell therapy

With the rapid advancement of genetic engineering technologies, CAR-NK cell therapy, as an emerging immunotherapeutic approach, has demonstrated significant potential. CAR-NK cells recognize and eliminate tumor cells through chimeric antigen receptors (CARs). Genetic engineering techniques have enha...

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Bibliographic Details
Main Authors: Caidong Hu, Wenhong Lai, Bin Tian, Xi Xu, Shuiling Xie, Wenting Zhong, Huiqiang Kang, Xiaoyun Chen, Hailiang Li, Jingxin Xu, Liping Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
CAR-NK cells
genetic engineering
NK cell expansion
vectors for CAR expression
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1600411/full
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