The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria
Cerebral malaria is a severe complication of Plasmodium falciparum infection associated with high mortality even when highly effective antiparasitic therapy is used. Adjunctive therapies that modify the pathophysiological processes caused by malaria are a possible way to improve outcome. This review...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/513865 |
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| _version_ | 1832545292832997376 |
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| author | Lena Serghides |
| author_facet | Lena Serghides |
| author_sort | Lena Serghides |
| collection | DOAJ |
| description | Cerebral malaria is a severe complication of Plasmodium falciparum infection associated with high mortality even when highly effective antiparasitic therapy is used. Adjunctive therapies that modify the pathophysiological processes caused by malaria are a possible way to improve outcome. This review focuses on the utility of PPARγ agonists as an adjunctive therapy for the treatment of cerebral malaria. The current knowledge of PPARγ agonist use in malaria is summarized. Findings from experimental CNS injury and disease models that demonstrate the potential for PPARγ agonists as an adjunctive therapy for cerebral malaria are also discussed. |
| format | Article |
| id | doaj-art-31b1979bfc1c404a8458737937cb9799 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-31b1979bfc1c404a8458737937cb97992025-02-03T07:26:16ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/513865513865The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral MalariaLena Serghides0Sandra A. Rotman Laboratories, McLaughlin-Rotman Centre for Global Health, Toronto General Hospital, University Health Network, 101 College Street, Suite 10-359, Toronto, ON, M5G 1L7, CanadaCerebral malaria is a severe complication of Plasmodium falciparum infection associated with high mortality even when highly effective antiparasitic therapy is used. Adjunctive therapies that modify the pathophysiological processes caused by malaria are a possible way to improve outcome. This review focuses on the utility of PPARγ agonists as an adjunctive therapy for the treatment of cerebral malaria. The current knowledge of PPARγ agonist use in malaria is summarized. Findings from experimental CNS injury and disease models that demonstrate the potential for PPARγ agonists as an adjunctive therapy for cerebral malaria are also discussed.http://dx.doi.org/10.1155/2012/513865 |
| spellingShingle | Lena Serghides The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria PPAR Research |
| title | The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria |
| title_full | The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria |
| title_fullStr | The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria |
| title_full_unstemmed | The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria |
| title_short | The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria |
| title_sort | case for the use of pparγ agonists as an adjunctive therapy for cerebral malaria |
| url | http://dx.doi.org/10.1155/2012/513865 |
| work_keys_str_mv | AT lenaserghides thecasefortheuseofppargagonistsasanadjunctivetherapyforcerebralmalaria AT lenaserghides casefortheuseofppargagonistsasanadjunctivetherapyforcerebralmalaria |