Biomarkers of Oxidative Stress in Huntington's Disease and Other Neurological Disorders: a Comparative Study
<strong>Foundation:</strong> biomarkers of oxidative stress in Huntington's disease could predict the course of the disease and evaluate new treatments, but their nonspecific nature seems to prevent the identification of any useful marker. Clarifying similarities and differences of...
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Universidad de las Ciencias Médicas de Cienfuegos
2023-12-01
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| Online Access: | https://revfinlay.sld.cu/index.php/finlay/article/view/1314 |
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| author | Marisol Peña Sánchez Gabriel Andrés Peña de los Santos Gretel Riverón Forment Gloria Lara Fernández Tatiana Acosta Sánchez Alina González-Quevedo Monteagudo |
| author_facet | Marisol Peña Sánchez Gabriel Andrés Peña de los Santos Gretel Riverón Forment Gloria Lara Fernández Tatiana Acosta Sánchez Alina González-Quevedo Monteagudo |
| author_sort | Marisol Peña Sánchez |
| collection | DOAJ |
| description | <strong>Foundation:</strong> biomarkers of oxidative stress in Huntington's disease could predict the course of the disease and evaluate new treatments, but their nonspecific nature seems to prevent the identification of any useful marker. Clarifying similarities and differences of this phenomenon and its behavior with clinical characteristics may be essential. <br /><strong>Objective:</strong> compare biomarkers of oxidative stress between patients with Huntington's disease and other neurological disorders. <br /><strong>Methods:</strong> an analytical, retrospective and case-control study was carried out (Huntington's disease, amyotrophic lateral sclerosis, spinocerebellar ataxia type 2 and ischemic stroke: acute and chronic stage). Demographic and clinical variables and markers of oxidative damage (malonildialdehyde, advanced protein oxidation products) and antioxidants (superoxide dismutase: catalase: glutathione peroxidase, plasma antioxidant capacity) were collected. <br /><strong>Results:</strong> there were significant differences in malonyldialdehyde in Huntington's disease compared to the control (p=0.02), but not with the rest of the groups. The enzyme superoxide dismutase in Huntington's disease was statistically lower compared to amyotrophic lateral sclerosis, although for catalase it was higher in relation to the rest of the patients. FRAP in Huntington's disease was significantly lower versus amyotrophic lateral sclerosis and acute ischemic stroke. Advanced products of protein oxidation were directly correlated with the biological and onset ages of Huntington's disease. Motor activity in amyotrophic lateral sclerosis and neurological deficit in acute ischemic stroke were correlated with malonyldialdehyde and glutathione peroxidase, respectively. <br /><strong>Conclusions:</strong> huntington's disease seems to show specific characteristics in its antioxidant system. Protein oxidation could be related to the accumulation of mutated huntingtin over time. |
| format | Article |
| id | doaj-art-3196ef6e4f4141299d0a5a6598ea4c65 |
| institution | Kabale University |
| issn | 2221-2434 |
| language | Spanish |
| publishDate | 2023-12-01 |
| publisher | Universidad de las Ciencias Médicas de Cienfuegos |
| record_format | Article |
| series | Revista Finlay |
| spelling | doaj-art-3196ef6e4f4141299d0a5a6598ea4c652025-01-30T21:22:02ZspaUniversidad de las Ciencias Médicas de CienfuegosRevista Finlay2221-24342023-12-01134435445680Biomarkers of Oxidative Stress in Huntington's Disease and Other Neurological Disorders: a Comparative StudyMarisol Peña Sánchez0Gabriel Andrés Peña de los Santos1Gretel Riverón Forment2Gloria Lara Fernández3Tatiana Acosta Sánchez4Alina González-Quevedo Monteagudo5Instituto de Neurología y Neurocirugía. La Habana. Cuba.Hospital Provincial Pedro Emilio Marchena. Bonao. República Domicana.Centro Nacional de Genética Médica. La Habana. Cuba.Instituto de Neurología y Neurocirugía. La Habana. CubaCentro Nacional de Genética Médica. La Habana.Instituto de Neurología y Neurocirugía. La Habana. Cuba.<strong>Foundation:</strong> biomarkers of oxidative stress in Huntington's disease could predict the course of the disease and evaluate new treatments, but their nonspecific nature seems to prevent the identification of any useful marker. Clarifying similarities and differences of this phenomenon and its behavior with clinical characteristics may be essential. <br /><strong>Objective:</strong> compare biomarkers of oxidative stress between patients with Huntington's disease and other neurological disorders. <br /><strong>Methods:</strong> an analytical, retrospective and case-control study was carried out (Huntington's disease, amyotrophic lateral sclerosis, spinocerebellar ataxia type 2 and ischemic stroke: acute and chronic stage). Demographic and clinical variables and markers of oxidative damage (malonildialdehyde, advanced protein oxidation products) and antioxidants (superoxide dismutase: catalase: glutathione peroxidase, plasma antioxidant capacity) were collected. <br /><strong>Results:</strong> there were significant differences in malonyldialdehyde in Huntington's disease compared to the control (p=0.02), but not with the rest of the groups. The enzyme superoxide dismutase in Huntington's disease was statistically lower compared to amyotrophic lateral sclerosis, although for catalase it was higher in relation to the rest of the patients. FRAP in Huntington's disease was significantly lower versus amyotrophic lateral sclerosis and acute ischemic stroke. Advanced products of protein oxidation were directly correlated with the biological and onset ages of Huntington's disease. Motor activity in amyotrophic lateral sclerosis and neurological deficit in acute ischemic stroke were correlated with malonyldialdehyde and glutathione peroxidase, respectively. <br /><strong>Conclusions:</strong> huntington's disease seems to show specific characteristics in its antioxidant system. Protein oxidation could be related to the accumulation of mutated huntingtin over time.https://revfinlay.sld.cu/index.php/finlay/article/view/1314sistema nervioso centralenfermedades no transmisiblesbiomarcadoresenfermedad de huntingtontrastorno neurológico |
| spellingShingle | Marisol Peña Sánchez Gabriel Andrés Peña de los Santos Gretel Riverón Forment Gloria Lara Fernández Tatiana Acosta Sánchez Alina González-Quevedo Monteagudo Biomarkers of Oxidative Stress in Huntington's Disease and Other Neurological Disorders: a Comparative Study Revista Finlay sistema nervioso central enfermedades no transmisibles biomarcadores enfermedad de huntington trastorno neurológico |
| title | Biomarkers of Oxidative Stress in Huntington's Disease and Other Neurological Disorders: a Comparative Study |
| title_full | Biomarkers of Oxidative Stress in Huntington's Disease and Other Neurological Disorders: a Comparative Study |
| title_fullStr | Biomarkers of Oxidative Stress in Huntington's Disease and Other Neurological Disorders: a Comparative Study |
| title_full_unstemmed | Biomarkers of Oxidative Stress in Huntington's Disease and Other Neurological Disorders: a Comparative Study |
| title_short | Biomarkers of Oxidative Stress in Huntington's Disease and Other Neurological Disorders: a Comparative Study |
| title_sort | biomarkers of oxidative stress in huntington s disease and other neurological disorders a comparative study |
| topic | sistema nervioso central enfermedades no transmisibles biomarcadores enfermedad de huntington trastorno neurológico |
| url | https://revfinlay.sld.cu/index.php/finlay/article/view/1314 |
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