Oxidative stress: an overview of past research and future insights

‘Oxidative stress' (OS) refers to the deviations in redox biology inside biological systems. This term has been used to illustrate the imbalance between oxidants and antioxidants, which has been a subject of extensive research. The obtained findings suggest that many diseases are linked to OS,...

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Main Authors: Aaser M. Abdelazim, Mosleh M. Abomughaid
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:All Life
Subjects:
Online Access:http://dx.doi.org/10.1080/26895293.2024.2316092
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author Aaser M. Abdelazim
Mosleh M. Abomughaid
author_facet Aaser M. Abdelazim
Mosleh M. Abomughaid
author_sort Aaser M. Abdelazim
collection DOAJ
description ‘Oxidative stress' (OS) refers to the deviations in redox biology inside biological systems. This term has been used to illustrate the imbalance between oxidants and antioxidants, which has been a subject of extensive research. The obtained findings suggest that many diseases are linked to OS, including diabetes mellitusinflammation, cancers, autoimmune disorders and neurodegenerative diseases. More recently, significant advances in biochemistry and molecular biology have enabled researchers to find master switches of various OS mechanisms and associate OS development to many biological paradigms. In this review, a brief overview of OS research is provided to offer insight into its future directions. Most importantly, the need for a greater understanding of the OS molecular mechanisms and its vital role in the progression of many disorders is emphasized. Likewise, more work is needed on the utility of reactive oxygen species markers as a diagnostic tool.
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spelling doaj-art-31939cbd9d9a4cfa9ad21c8e1689a94f2025-01-20T14:38:00ZengTaylor & Francis GroupAll Life2689-53072024-12-01170110.1080/26895293.2024.23160922316092Oxidative stress: an overview of past research and future insightsAaser M. Abdelazim0Mosleh M. Abomughaid1University of BishaUniversity of Bisha‘Oxidative stress' (OS) refers to the deviations in redox biology inside biological systems. This term has been used to illustrate the imbalance between oxidants and antioxidants, which has been a subject of extensive research. The obtained findings suggest that many diseases are linked to OS, including diabetes mellitusinflammation, cancers, autoimmune disorders and neurodegenerative diseases. More recently, significant advances in biochemistry and molecular biology have enabled researchers to find master switches of various OS mechanisms and associate OS development to many biological paradigms. In this review, a brief overview of OS research is provided to offer insight into its future directions. Most importantly, the need for a greater understanding of the OS molecular mechanisms and its vital role in the progression of many disorders is emphasized. Likewise, more work is needed on the utility of reactive oxygen species markers as a diagnostic tool.http://dx.doi.org/10.1080/26895293.2024.2316092molecular switchesoxidative stressproteomicsredox biology
spellingShingle Aaser M. Abdelazim
Mosleh M. Abomughaid
Oxidative stress: an overview of past research and future insights
All Life
molecular switches
oxidative stress
proteomics
redox biology
title Oxidative stress: an overview of past research and future insights
title_full Oxidative stress: an overview of past research and future insights
title_fullStr Oxidative stress: an overview of past research and future insights
title_full_unstemmed Oxidative stress: an overview of past research and future insights
title_short Oxidative stress: an overview of past research and future insights
title_sort oxidative stress an overview of past research and future insights
topic molecular switches
oxidative stress
proteomics
redox biology
url http://dx.doi.org/10.1080/26895293.2024.2316092
work_keys_str_mv AT aasermabdelazim oxidativestressanoverviewofpastresearchandfutureinsights
AT moslehmabomughaid oxidativestressanoverviewofpastresearchandfutureinsights